Patients with a BMI of ≥30 kg/m2 or ≥27 kg/m2 with 1 or more weight-related comorbidities may be candidates for treatment with Saxenda® as an adjunct to a reduced-calorie diet and increased physical activity.
SAXENDA is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and the symptoms of thyroid tumors (4, 5.1, 13.1).
Furthermore, in a phase IV clinical study of FDA data on the drug Saxenda, migraines were a side effect [47].
Tricyclic antidepressants (TCAs) such as amitriptyline are older antidepressants often associated with weight gain and increased appetite. Whilst there is no pharmacological interaction with Saxenda, the opposing effects on weight may reduce the overall effectiveness of weight management efforts.
However, studies have also shown that Ozempic leads to fewer side effects and adverse events than Saxenda, with people tolerating Ozempic better.
GPs are reminded the GLP-1 receptor agonist Saxenda will no longer be available in Australia by year end. Saxenda will be unavailable for purchase in Australia after December 2025, and GPs are being advised to discuss alternative treatments with patients.
Aiming for a gradual weight loss of 1 to 2 pounds per week is generally considered sustainable and safe. Over six months, this can translate to a weight loss of 20 lbs, provided that the individual commits to using Saxenda alongside a disciplined diet and consistent exercise regimen.
There may be an interaction between liraglutide and any of the following:
Bupropion (brand name Wellbutrin) stands out as an antidepressant that can promote weight loss. Unlike many other antidepressants, bupropion doesn't typically cause weight gain.
It's best to take it before you go to bed because it can make you sleepy. If you still feel drowsy in the morning you could try taking it earlier in the evening. Amitriptyline does not usually upset your stomach.
'Ozempic hands' is an informal term describing visible changes in hand appearance—such as more prominent veins, tendons, and bones—reported by some individuals taking semaglutide (Ozempic or Wegovy).
The most common side effects of Saxenda® include:
Diarrhea. Constipation.
Our tips to help with headaches:
If you're struggling with obesity, here's how you can give your body a fighting chance at losing weight, even with hypothyroidism.
Foods to avoid while on Saxenda® to reduce side effects
Saxenda® (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with obesity or overweight (excess weight) who also have weight related medical problems, and children aged 12-17 years with a body weight above 132 pounds (60kg) and obesity to help them lose weight and keep the weight off.
Wellbutrin® (bupropion) is often associated with weight loss. It may even be combined with another drug called naltrexone — together, they're sold under the brand name Contrave® — to enhance weight loss among people living with obesity. Desyrel® (trazodone) may lead to some weight gain.
Sustainable weight loss requires addressing psychological factors like stress, emotional eating, and negative body image. Behavioural changes and mindset shifts are crucial for long-term success.
There are many medications that may cause hair loss. Common examples include chemotherapy, antidepressants, and anti-seizure medications. Birth control pills, azole antifungals, and some arthritis and antithyroid medications may also lead to hair loss. Oral retinoids, tamoxifen, and blood thinners can cause hair loss.
The most common side effects of Saxenda that affect more than 1 in 10 people, include: nausea or vomiting (feeling or being sick) constipation.
Saxenda is given as an injection under the skin (subcutaneous injection). The best places to inject are the front of your waist (abdomen), the front of your thighs or your upper arm. Change the place where you inject each day to reduce the risk of developing lumps. Do not inject into a vein or muscle.
Oral options include Contrave (naltrexone / bupropion), Qsymia (phentermine / topiramate ER), and Xenical (orlistat). Plenity is an FDA-approved medical device that you take by mouth. If you're unable to fill your Saxenda prescription, your prescriber may consider an alternative treatment.
You may start seeing some weight loss with Saxenda in as little as 2 weeks. And you'll likely continue losing weight during the first few months of treatment. Most people see Saxenda's maximum effects about 6 months after starting it.
In-use Saxenda pens can be stored at room temperature below 30°C for up to 30 days, making them suitable for air travel in hand luggage. For unopened pens requiring refrigeration, use an insulated medication travel case with cooling packs, ensuring the pen doesn't freeze.
No. Liraglutide, the active ingredient in Saxenda, is available only as an injection. But a similar medication called semaglutide comes in injectable (Ozempic, Wegovy) and pill (Rybelsus) forms.