Ozempic can result in greater weight loss than metformin On average, people taking the highest Ozempic dose during clinical trials lost about 15 lbs over 40 weeks (about 9 months). Experts consider metformin to be a “weight-neutral” medication that has the potential to cause modest weight loss.
Does Ozempic work better than metformin? Because Ozempic and metformin work in different ways, neither necessarily works better than the other. Depending on the dose, either metformin or Ozempic may lower blood sugar levels more than the other drug.
Ozempic is often given when metformin—which is first in line to be prescribed— doesn't work for someone with type 2 diabetes mellitus. Healthcare professionals also prescribe metformin and Ozempic off-label to treat overweight and obesity as part of a holistic approach to weight care.
One long term study published in 2019 found that 28.5% of those taking metformin lost about 5% or less of their body weight during the first year. And those who lost weight on metformin during the first year had the greatest success with weight loss during years 6-15 (15).
Mounjaro is a more effective drug than Ozempic. As demonstrated above, tirzepatide (the active ingredient in Mounjaro) leads to more clinically significant weight loss and blood sugar reductions than semaglutide (the active ingredient in Ozempic).
Ozempic isn't approved for weight loss. But because of how it works, some people taking Ozempic lose weight as a side effect. If you don't have diabetes, taking Ozempic for weight loss is considered an off-label use. Wegovy, a higher-dose version of Ozempic, is approved to help people manage their weight.
A person can stay on Ozempic® so long as they are tolerating the medication and it is deemed appropriate by their treating provider. There is no specific time frame when someone should stop taking Ozempic as it is a medication that is intended for chronic (long-term) use.
Metformin and weight loss
In a much larger trial in over 4,000 people with type 2 diabetes, it was found metformin use was associated with a 2.4 kg (roughly 5.3 lbs) weight loss over a four-year period. There are a few ways that metformin might impact weight. One is that the medication can reduce your appetite.
Metformin, an oral type 2 diabetes medicine, may lead to a modest weight loss and does not usually lead to significant, if any, weight gain. In various clinical studies, when metformin was used alone, it led to a weight loss of 0.7 to 3.8 kg (1.5 to 8.4 lbs) in patients.
If you don't have type 2 diabetes, your doctor may sign off on this drug if you have obesity and are struggling to lose weight. But again, metformin isn't a substitute for healthy eating and regular exercise, which are keys to sustainable weight loss.
Most people with a new diagnosis of type 2 diabetes start taking metformin first. If you control your sugar well, you may not need to change a thing. However, if you still struggle to keep your sugar within the target range, you can also try Ozempic. Some people prefer to swallow a pill rather than take an injection.
You may need a higher dosage of Ozempic
The same holds true for Ozempic's weight loss results. People taking higher doses of Ozempic tend to lose more weight. In the landmark study we cited above, people lost 7% of their body weight, on average, within a year and a half of taking 1mg of semaglutide.
On average, a user can lose about 3 to 5% of their body weight after using Ozempic for a month regularly. This equates to about 4 to 6 pounds on average. Using a higher potency of the drug may result in more weight loss, but it isn't recommended that you start taking it right away.
Mounjaro. Mounjaro (tirzepatide) is a newer once-weekly injection for Type 2 diabetes. It works on the same targets in the body as Ozempic, plus an additional target. This results in greater A1C reduction and weight loss compared to Ozempic.
Closely related to fried, greasy foods and snacks, highly saturated fats (including trans fats) are known to exacerbate GI issues. Every day staples like whole milk, heavy cream, full-fat cheese, butter, ice cream and most red meats may cause additional gastrointestinal distress for someone on Ozempic.
You start feeling those usual hunger pangs again, and consequently, you may start eating more to satisfy that hunger. An increase in your consumption can lead to the regaining of weight that was lost. A 2022 study found that most individuals gain weight back a year after stopping the medication.
Some of the most effective prescription injectable weight loss medications available include: Mounjaro, Ozempic and Wegovy - these are diabetes drugs originally and now used to treat obesity. Although these injectable drugs can help users lose weight there are some dangers and caveats!
Since Ozempic stimulates insulin secretion from the pancreas and reduces appetite, it further improves blood glucose levels and weight loss in people with type 2 diabetes. Combining metformin and Ozempic may enhance the effectiveness of both drugs. You can take Ozempic and metformin together or separately.
Is Metformin an Effective Weight Loss Pill? No. The amount of weight you're likely to lose is low. In one diabetes prevention study, 29% of people lost 5% or more of their body weight and just 8% lost around 10%.
Someone who is nondiabetic might notice decreases in inflammation, anti-aging benefits, and some weight loss, says Acebedo.
Once you start on an injectable medication, you may find it takes a few weeks to start seeing results, although some people may see changes in a week. You will also start on a low dose to give your body time to slowly adjust to feel satisfied and not feel hungry.