Why Shouldn't You Stop Taking Metformin? Metformin works by decreasing the amount of sugar your liver releases into your blood, making your body more sensitive to insulin's effects. If you suddenly discontinue use, it can lead to dangerously high blood sugar levels.
Metformin (brand name: Glucophage) will be in your system for 96.8 hours which is approximately 4 days. Metformin has an elimination half-life of approximately 17.6 hours.
For patients who are already on metformin, I do not decrease the dose unless the A1c is 6.0% or less. I might reduce the dose by half every 3 months, as long as the A1c stays at 6.0% or less. I stop the final 500 mg of metformin when the A1c is 6.0% or less for at least 3 months.
Summary. Metformin is a common drug for the treatment of diabetes. If you successfully manage your diabetes to remission, it's possible to stop taking metformin. Lifestyle and dietary changes can help you manage your blood sugar levels and possibly reach diabetes remission.
In general, for diabetes medications including oral hypoglycemic agents (e.g., metformin) and insulin, if you miss one dose, take the next one as soon as you remember it. However, if you remember close to the time of the next dose, then skip it and take the next dose instead. Do NOT double the dose.
Studies show that taking berberine can lower blood sugar levels to a similar extent as the popular diabetes drug metformin ( 4 ). In a study in 116 people with type 2 diabetes, the substance reduced fasting blood sugar levels by 20% and HbA1c (a marker for long-term blood sugar levels) by 12% ( 5 ).
Missing a dose can cause a rise in your blood glucose levels, which can lead to serious complications over time.
Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it.
Precose, Januvia, Victoza, Glucotrol XL, and Actos are some metformin alternatives. Get the full list here. Metformin is an oral prescription medication used in the treatment of Type 2 diabetes mellitus. It belongs to a class of drugs known as biguanides.
A meta-analysis study (2) done on three randomized clinical trials showed that metformin decreases the rate of conversion from prediabetes to diabetes. The effective dose was 850 mg twice daily and lower dosage 250 mg twice or 3 times daily was not very effective.
The administration of metformin, as glucophage retard, at bedtime instead of supper time may improve diabetes control by reducing morning hyperglycemia.
Long-term side effects
Taking metformin can cause vitamin B12 deficiency if you take it for a long time. This can make you feel very tired, breathless and faint, so your doctor may check the vitamin B12 level in your blood. If your vitamin B12 levels become too low, vitamin B12 supplements will help.
Many studies have demonstrated that once or twice daily administration of ER metformin is as safe and efficacious as twice daily IR metformin, overall providing continued glycemic control for up to 24 weeks of treatment [5].
Insulin remains the most effective therapy to lower glucose, particularly in comparison to most oral medicines for type 2 (including metformin).
Tree turmeric (Berberis aristate) is a shrub found in India and Nepal. It contains high amounts of a chemical called berberine.
As already discussed, metformin can result in sleep disturbance, and this might affect normal dream patterns. Nightmares are reported in patients receiving metformin.
You'll have more energy as your body uses insulin more efficiently. Common diabetes-related symptoms, such as blurry vision, being thirsty all of the time, or having to pee a lot, improve or disappear.
Should you drink a lot of water when consuming this medicine? Metformin must be consumed with meals to assist lower stomach or bowel side effects that might happen during the initial few weeks of treatment. The tablet or extended-release tablet must be taken whole with a full glass of water.
Dosage and strength
The maximum daily dose is 2,000mg a day. This can be taken as four 500mg tablets a day. Liquid metformin should be taken in 5ml doses of 500mg, 850mg or 1,000mg.
Metformin doesn't cause kidney damage. The kidneys process and clear the medication out of your system through your urine. If your kidneys don't function properly, there's concern that metformin can build up in your system and cause a condition called lactic acidosis.
On average, most patients find that their HbA1c levels drop by as much as 1.5% on this medication.