Atorvastatin or fluvastatin are usually recommended because there is no need to adjust the dose according to the glomerular filtration rate [28]. In patients without diagnosed atherosclerotic cardiovascular disease, it is indicated a moderate dose of statin, such as atorvastatin 20 mg daily [28].
Regardless of age, those who have suffered a heart attack or stroke will benefit from taking a statin.
Serious adverse events are very rare. Among the individual medications, studies have shown that simvastatin (Zocor®) and pravastatin (Pravachol®) seem to be safer and better tolerated than the other statins.
“So everyone over 75 is at high risk.” On the other hand, older patients are more likely to be on multiple medications that can interact with statins. And there's some evidence that this age group may be more prone to statin side effects, such as muscle pain, an increased risk of diabetes, and liver problems.
An alternative medication, bempedoic acid, significantly lowers cholesterol and the risk of heart attacks, as well as reducing the need for a procedure that unblocks clogged arteries, according to a large clinical trial presented Saturday at the annual meeting of the American College of Cardiology.
By Lauran Neergaard • Published March 6, 2023
shows the cholesterol-lowering drug Nexletol made by Esperion Therapeutics Inc. Drugs known as statins are the first-choice treatment for high cholesterol but millions of people who can't or won't take those pills because of side effects may have another option.
The new bempedoic acid drug – currently called Nexletol – is being developed by US-based Esperion Therapeutics and will go to the Therapeutics Goods Administration for approval for use in Australia.
In a large population cohort study of patients aged 65 and older, investigators found that discontinuing statins, even while maintaining antihypertensives, antidiabetics, and antiplatelet medications, was associated with an increased risk of fatal and non-fatal cardiovascular outcomes, cardiovascular hospital ...
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so. To understand more about your heart health, take a health risk assessment at Baptist Health.
However, statins can cause side effects in older adults including gait disturbances, which can lead to falls; increased blood glucose levels and incidence of diabetes mellitus; development of cataracts; liver toxicity; and muscle complications such as rhabdomyolysis, which is a potentially life-threatening condition.
Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.
We showed that fluvastatin 20 mg/ezetimibe 10 mg was the most efficacious treatment regarding both renal outcomes.
So current medical guidelines recommend statins for people in that no-heart-disease category, a strategy called primary prevention — but only for those up to age 75. Yet almost half of adults aged 75 and older take statins, the Centers for Disease Control and Prevention has reported.
The American College of Cardiology and American Heart Association developed some prescription guidelines. Typically, if a person's LDL cholesterol (bad cholesterol) is 190 or higher, they're often advised to start a statin.
Neurological side effects
The FDA warns on statin labels that some people have developed memory loss or confusion while taking statins.
Statins in particular can help lower your LDL cholesterol (the “bad” cholesterol) by 30% to 50%, but their effects go away after you stop taking them.
You usually have to continue taking statins for life because if you stop taking them, your cholesterol will return to a high level. If you forget to take your dose, do not take an extra one to make up for it.
Grapefruit juice is the only food or drink that has a direct interaction with statins. Statins do not directly interact with any food but people taking statins should moderate their intake of saturated fats to help lower their LDL cholesterol and overall risk of cardiovascular disease.
Statins are medications designed to lower cholesterol to decrease your risk of cardiovascular issues, such as heart attacks. Recent research shows that people 75 and older who go off statins have an increased risk of hospitalization because of cardiovascular problems.
Taking statins can enable you to live years longer. That's because for every millimole per liter you drop your bad LDL cholesterol, you may live three years longer––maybe even six years longer, depending on which study you're reading.
Currently, more than 60 percent of older people in the United States who, like me, have high cholesterol take a statin to help prevent a heart attack or stroke.
Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes.
A newer drug called Nexletol was approved in 2020 by the FDA to treat high cholesterol, but the new study published in NEJM shows that the drug also reduces the risk of heart disease. Researchers believe this data supports using Nexletol as a safe and effective alternative for many people who cannot take statins.