Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus.
While many patients experience dry eyes, dry mouth, fatigue and joint pain, Sjögren's can also cause dysfunction of organs such as the kidneys, gastrointestinal system, blood vessels, lungs, liver, pancreas, and the central nervous system. Patients also have a higher chance of developing lymphoma.
Activated aryl hydrocarbon receptor may interact with latent Epstein-Barr virus (EBV) infection, which in turn may predispose to the development of Sjögren's syndrome. It is estimated that the population is 95% positive for EBV serology.
Sjogren's syndrome is a chronic autoimmune disorder in which the body's own immune system attacks the glands that produce tears and saliva. Foods that help are omega-3 fatty acids, organic meat, whole fruits and vegetables. Bad foods include trans fat, high glycemic, red meat, dairy, and artificial sweeteners.
Global cognitive impairment in Sjögren's
Most patients experience “brain fog” symptoms, which manifest as memory lapses, forgetfulness, mental confusion, and difficulties in concentrating, organizing, or anticipating future events.
The main symptoms are dry eyes and mouth, but other parts of the body may be affected as well, with many people reporting fatigue and joint and muscle pain. In addition, the disease can damage the lungs, kidneys, and nervous system. Sjögren's syndrome predominantly affects women.
You wake up feeling aches and pains
Typically, the pain strikes in small joints like the fingers, wrists, and ankles, though the tenderness and swelling can also show up in the knees, shoulders, and hips.
Dry eyes, corneal ulcerations and infections. Dry nose, recurrent sinusitis, nosebleeds. Dry mouth, mouth sores, dental decay, difficulty with chewing, speech, taste and dentures. Swollen, painful parotid/salivary glands.
The neurological complications of Sjögren's syndrome are extensive and range from cognitive difficulties, to burning toes and feet.
Hydroxychloroquine; first-line treatment. Methotrexate. Hydroxychloroquine plus methotrexate. Short-term (1 month or less) corticosteroids (15 mg or less a day); long-term corticosteroids (≤15 mg/d for more than 1 month) may be useful, but efforts should be made to find a steroid-sparing agent as soon as possible.
The large intestine is where liquid is reabsorbed. Constipation and diarrhea can occur with Sjögren's. Increase vegetables.
Sjogren's Syndrome patients often complain of mental fatigue or “brain fog.” Brain fog impairs focus, causes fuzzy concentration, and contributes to difficulty in problem-solving. Keep your stress levels low, and give your brain a workout with crosswords, puzzles, reading, adult coloring books, or online brain games.
Results: SS-related dry eye is a progressive condition with major negative impact on the quality-of-life of afflicted patients, not only due to symptoms of ocular discomfort but also visual dysfunction. In addition, SS can lead to corneal melt/perforation, uveitis, scleritis, retinal vasculitis, and optic neuritis.
In most people with Sjögren syndrome, dry eyes and dry mouth are the primary features of the disorder, and general health and life expectancy are largely unaffected.
The condition may progress slowly, so the typical symptoms of dry eyes and mouth may take years to show. However, rapid onset can also occur. Symptoms can be mild, moderate or severe, and the progression is often unpredictable.
Primary Sjogren's develops alone, but secondary Sjogren's co-occurs with another condition, such as lupus. The symptoms are similar, and both can be severe. Sjogren's is a serious condition, but timely treatment can mean that complications are less likely to develop, and tissue damage is less likely to occur.
The patients with Sjogren's had an overall lower quality of sleep [8]. All of the studies in the systematic review noted that there is an increased number of nighttime awakenings in Sjogren's patients.
Sjögren's syndrome doesn't cause weight gain. However, medications (like steroids) used to treat symptoms may cause weight gain. Also, there are conditions like hypothyroidism that may be linked to Sjögren's syndrome that can result in unintended weight gain.
Falk: What kinds of factors can make Sjogren's worse? What is the effect, for example, of stress? Jonas: Well, like all autoimmune diseases, patients who feel stressed or are under unusual stress will often have exacerbation of their symptoms. Learning to manage that stress in your life is very important.
It may include forgetfulness, spaciness, confusion, decreased ability to pay attention, an inability to focus, and difficulty in processing information.
Avoiding foods that tend to exacerbate symptoms including alcohol, caffeine, acidic foods, and spicy foods.