Common metformin alternatives are SGLT-2 Inhibitors (Invokana, Farxiga, Jardiance, and Steglatro), GLP – 1 Receptor Agonists ( Bydureon, Byetta, Ozempic, Adlyxin, Rybelsus, Trulicity, and Victoza), Sulfonylureas or SFUs { DiaBeta, Glynase, or Micronase (glyburide or glibenclamide) Amaryl (glimepiride) Diabinese ( ...
More serious side effects are rare. They include severe allergic reactions and a condition called lactic acidosis, a buildup of lactic acid in the bloodstream. The risk for this is higher among people with significant kidney disease, so doctors tend to avoid prescribing metformin for them.
Proven long-term side effects of metformin
Of those discussed above, low vitamin B12 levels is the only proven long-term metformin side effect. But, as mentioned, low vitamin B12 levels can cause other problems, including anemia. That's why it's important to go for all recommended blood tests while taking metformin.
Ozempic and metformin help most people to lower their average blood sugar levels (as measured by an A1c blood test), and these effects are quite significant. Clinical trials have established that (at its maximum dose) metformin can help decrease A1c by 1.5%, while an average dose of Ozempic can decrease A1c by 1.4%.
There are six other major classes of blood-sugar lowering drugs used in Type 2 diabetes. Of these, the SGLT2 inhibitors (short for sodium-glucose co-transporter) are emerging as the next best drug after metformin.
Under certain conditions, too much metformin can cause lactic acidosis. The symptoms of lactic acidosis are severe and quick to appear, and usually occur when other health problems not related to the medicine are present and are very severe, such as a heart attack or kidney failure.
Most experts consider metformin to be the safest medicine for type 2 diabetes because it has been used for many decades, is effective, affordable, and safe. Metformin is recommended as a first-line treatment for type 2 diabetes by the American Diabetes Association (ADA).
If you stop taking metformin abruptly, your health may suffer. You may experience side effects such as higher blood sugars, an increased A1c, and even weight gain. Over time, higher blood sugar levels can lead to diabetes complications, including: Retinopathy and blindness.
As a result, cinnamon seems to be as effective as metformin in increasing the Insulin sensitivity. In line with this study, Maleki et al. showed that HDL and insulin sensitivity were increased by the cinnamon supplementation while LDL, TG, and blood glucose were decreased in patients with PCOS (17).
As much as possible, avoid white bread, white rice, white pasta, candy, soda, desserts, and snacks like chips or crackers. Eating foods that can spike your blood sugar will not necessarily make the metformin not work, however, it will increase the burden it has to work against.
If metformin is not helping you meet your blood sugar goals, your medical provider may also recommend you take Ozempic.
Ozempic is an FDA-approved prescription medication for the treatment of type 2 diabetes in adults. It helps improve blood sugar in adults with type 2 diabetes and is proven to lower hemoglobin A1C, a measure of blood glucose over time, according to research cited on Ozempic's site.
Downsides
Common side effects of Ozempic include hypoglycemia (low blood sugar levels), nausea, vomiting, diarrhea, abdominal pain, and constipation. Ozempic needs to be given by injection under the skin (subcutaneous). However, self-administration is easy to learn for most people.
A. No, zero sugar soda uses artificial sweeteners, which increases people's weight. Increased weight, in turn, is linked to the worsening of diabetes. Hence, zero soda is not suitable for diabetes.
A person with diabetes should include a variety of fresh, whole foods in their diet, such as nutrient-dense fruits and vegetables. Bananas are a safe and nutritious fruit for people with diabetes to eat in moderation as part of a balanced, individualized eating plan.
Clinically apparent liver injury from metformin is very rare, fewer than a dozen cases having been described in the literature despite widespread use of this agent for several decades. The liver injury usually appears after 1 to 8 weeks, typically with symptoms of weakness and fatigue followed by jaundice.