Antidepressants can cause unpleasant side effects. Signs and symptoms such as nausea, weight gain or sleep problems can be common initially. For many people, these improve within weeks of starting an antidepressant. In some cases, however, antidepressants cause side effects that don't go away.
Common side-effects include nausea, drowsiness, dizziness, nervousness or anxiety, fatigue, loss of appetite and sexual problems. In higher dosage, these medications may increase blood pressure.
For people with chronic or severe depression, medication may be needed on a long-term basis. In these cases, antidepressants are often taken indefinitely. That is, in part, because depression is not an illness that can be cured.
When first starting antidepressants, some people have mild stomach upset, headache or fatigue, but these side effects often diminish in the first few weeks as the body adjusts. Some people gain weight, though many stay “weight neutral,” and some even lose weight, Dr. Cox says.
Our review supports the conclusion that antidepressants generally do more harm than good by disrupting a number of adaptive processes regulated by serotonin. However, there may be specific conditions for which their use is warranted (e.g., cancer, recovery from stroke).
In other words, antidepressants improved symptoms in about an extra 20 out of 100 people. Antidepressants can also relieve long-term symptoms of chronic depressive disorder (dysthymia) and chronic depression, and help make them go away completely. An antidepressant can already have an effect within one or two weeks.
If the symptoms develop later or gradually, they may constitute a relapse of the depression. Ultimately, these withdrawal symptoms will improve with time, but they can be unpleasant for days and possibly even weeks. In time, the brain readjusts and people should experience a return to their normal state.
Tricyclic antidepressants — such as imipramine, nortriptyline (Pamelor), amitriptyline, doxepin and desipramine (Norpramin) — tend to cause more side effects than newer antidepressants.
As previously mentioned, antidepressants could have long-term effects on physical as well as mental health. Specifically, weight gain seems to be a common long-term risk, especially the medications that affect serotonin levels.
SSRIs treat depression by increasing levels of serotonin in the brain. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons.
It may be hard to believe that antidepressants can cause depression, but it could be true. The very reason you take depression medication can sometimes make symptoms worse. Depression is a mood disorder that can cause feelings of sadness and lack of energy, among other symptoms.
Unfortunately, antidepressant treatment for depression has been associated with increased anxiety, restlessness, and agitation in the early period following treatment initiation(11–13).
Exercise. Research suggests that regular exercise may be a more effective treatment for mild depression than antidepressants. Exercise helps boost levels of chemicals called serotonin and dopamine in the brain, which can lift your mood.
Taking antidepressants may help to lift your mood. This can help you feel more able to do things that don't feel possible while you're depressed. This may include using other types of support for your mental health.
Research suggests that depression doesn't spring from simply having too much or too little of certain brain chemicals. Rather, there are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, and stressful life events.
Some people are bothered by the idea that they might not be able to beat depression without medication. They think of antidepressants as a kind of crutch, and think they would see themselves as being weak and helpless if they had to rely on them. Others question whether they really need the medication to feel better.
The risks appear to climb as people age. In older adults, SSRI medications are associated with falls and fractures. Some studies have found a link between SSRI use and a higher risk of dementia.
There's a paradoxical period when a person first starts an antidepressant: they may actually begin to feel worse before feeling better. The underlying cause of this phenomenon is a bit of a mystery, but a new study from researchers at Otto-von-Guericke University in Germany explains why this might occur.
The people we spoke to initially experienced insomnia, feeling lethargic and sleepy, dizziness, headaches, vivid dreams, dry mouth or bad taste in the mouth, sickness or nausea, hallucinations, loss of appetite, sweating, memory problems.
Take your time.
You may be tempted to stop taking antidepressants as soon as your symptoms ease, but depression can return if you quit too soon. Clinicians generally recommend staying on the medication for six to nine months before considering going off it.
Antidepressants may take a while to kick in. You may feel some depression symptoms improve within the first couple weeks, but it can often take 4 to 8 weeks to feel the full effects of your medication. If you've taken your antidepressant for at least 4 weeks with no improvement, let your healthcare provider know.
Clinicians generally recommend staying on the medication for six to nine months before considering going off antidepressants. If you've had three or more recurrences of depression, make that at least two years.