Studies find that taking CoQ10 for at least one month can be supportive for improving your egg quality. Because of how your eggs develop in your body, giving yourself three months to focus on egg quality is optimal. Although it is possible to support your egg quality in just 30 days.
There is no established set dose for CoQ10. Recommended doses range from 100 to 600 mg per day for fertility. Taking smaller 100-200 mg doses throughout the day rather than one large dose is recommended for the best absorption.
CoQ10 supplementation has been shown to improve egg quality, sperm quality, and pregnancy rates. Sperm and eggs both take about 90 days to develop. For best results, fertility specialists recommend taking CoQ10 and other fertility supplements for 90+ days if possible.
It found that women who had been treated with CoQ10 had a higher number of oocytes retrieved, those oocytes had a higher fertilization rate and a higher number of high-quality embryos.
The recommended dosage of Co Q10 supplementation varies greatly. The suggested dose is usually between 50 to 600 mg daily in divided doses. There is controversy as to what the best dose of CoQ10 is for various medical conditions. It is often given at a dose between 100 mg and 300 mg per day.
Standard daily doses of CoQ10 range from 60 milligrams (mg) to 500 mg. The highest recommended dose is 1,200 mg.
Our CoQ10 gummies contain 200 mg per serving for optimal results. We asked one of our Medical Advisors, the "Egg Whisperer" Dr. Aimee what she thinks: "I tell all of my fertility patients to start taking CoQ10—and to continue taking it until they are finished having children."
Some studies have proposed that Coenzyme Q10 (CoQ10) supplementation may increase AMH levels in women with age-related fertility decline. Others suggest that CoQ10 dramatically can lower AMH in PCOS patients after receiving CoQ10 treatment. Resources: Journal of Assisted Reproduction and Genetics.
Oral CoQ10 supplementation in PCOS women increased the mean number of mature follicles (> 18 mm) (1.85 ± 0.27 vs. 1.3 ± 0.32, p < 0.001) and the ovulation rate per cycle (65.9% vs. 15.5%, p < 0.001) compared with no-treatment (one study) [16].
Supplements containing Myo-inositol, folic acid and melatonin have been shown to help improve egg quality and ovarian function.
Since the egg development cycle takes 3 months, one should ideally start at least three months in advance of an IVF cycle. Fertility doctors advise that women undergoing IVF should continue taking CoQ10 until they have a positive pregnancy test.
CoQ10 supplement side effects may include diarrhea, heartburn, and nausea. However, these are very rare. Additionally, individuals taking blood thinners and thyroid medications should discuss their options with their doctor before taking CoQ10 supplements.
Can CoQ10 affect ovulation? Unfortunately, there is no scientific research around CoQ10 and the timing of ovulation. That being said, there are studies suggesting higher CoQ10 levels are associated with better quality embryos, improved embryo function, and higher pregnancy rates.
Higher doses may be recommended for specific conditions. CoQ10 is fat soluble, so it should be taken with a meal containing fat so your body can absorb it. Also, taking CoQ10 at night may help with the body's ability to use it.
Mild side effects might include digestive problems such as: Upper abdominal pain. Loss of appetite.
Research has connected CoQ10 with increased cellular energy and blood flow which can help support the high energy demands of your hair follicles. CoQ10 may also stimulate the gene responsible for producing different types of hair keratins, especially the ones that are reduced during aging.
With superior bioavailability, ubiquinol is the most absorbable, body-ready, active form of CoQ10 – and that's why it's often recommended for specific health concerns, such as those concerning fertility.
Coenzyme Q10, or CoQ10.
CoQ10 can possibly improve egg quality, thicken the uterine lining and improve fertility rates for women with polycystic ovary syndrome (PCOS) who are also taking Clomid. In men, CoQ10 may increase sperm count and improve motility.
The results of high-quality studies have mostly shown that CoQ10 supplementation improves sperm quality, which comprises sperm concentration and motility (its ability to “swim”) [15, 17, 18, 19].
CoQ10, PCOS and Fertility
Those who supplemented with CoQ10 saw more follicles and greater endometrial thickness. Ovulation occurred in 65.9% in the CoQ10 group compared with only 15.5% in the control group. Pregnancy rate was significantly higher in the CoQ10 group (37.3%) versus the control group (6.0%).
While research surrounding CoQ10 and pregnancy is limited, most studies indicate CoQ10 is usually safe to take during pregnancy. However, as with all medications and supplements, you should consult your doctor to ensure that taking CoQ10 is safe for you.
CoQ10 supplements can be taken without a duration limit. Clinical studies of high doses have lasted several years without issue. At the very least, you should take CoQ10 for a few weeks. It's not an acute kind of supplement that you take on an as-needed basis.
In the case of dietary supplements, solubilized CoQ10 formulations show enhanced bioavailability. The T(max) is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma CoQ10 range from 0.40 to 1.91 micromol/l in healthy adults.
CoQ10 as a supplement is available in single capsule doses of 30, 60, 100, 200, 300, 400, and 600 mg. Although there is no established minimum or maximum effective dose, the average dose necessary to attain a therapeutic blood level of > 2.5 mcg/mL is 200 mg taken twice daily with a meal.