Recent preclinical and clinical studies have suggested that metformin not only improves chronic inflammation through the improvement of metabolic parameters such as hyperglycemia, insulin resistance and atherogenic dyslipidemia, but also has a direct anti-inflammatory action.
Metformin exhibits an anti-inflammatory action in cells and patients, in addition to its known antihyperglycemic effects.
Due to its inhibitory effect on the proinflammatory phenotype of immune cells, metformin seems to reduce auto-immune disease burden not only in several animal models, but has also shown beneficial results in some human trials.
Preclinical studies have shown that metformin has anti-arthritis, anti-inflammatory effects through several mechanisms including suppression of osteoclasts gene expression, down-regulation of IL-17-producing Th17 cells, up-regulation of Treg cells and lowering the production of pro-inflammatory cytokines (Kang et al., ...
Medicines called anti-VEGF drugs can slow down or reverse diabetic retinopathy. Other medicines, called corticosteroids, can also help. Laser treatment. To reduce swelling in your retina, eye doctors can use lasers to make the blood vessels shrink and stop leaking.
Some of the best sources of omega-3s are cold water fish, such as salmon and tuna, and tofu, walnuts, flax seeds and soybeans. Other anti-inflammatory foods include grapes, celery, blueberries, garlic, olive oil, tea and some spices (ginger, rosemary and turmeric).
Chronic low-grade inflammation found in many patients with diabetes. Salsalate, a generic non-steroidal anti-inflammatory drug (NSAID) used to treat arthritis, significantly lowered blood glucose levels and decreased inflammatory mediators in patients with type 2 diabetes.
We also determined that metformin exposure leads to increased production of collagen I-III and decreased activation of NF-kB(p65) activity.
Metformin is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly.
Therefore, glycemic control in diabetic patients is vital for bone health. Metformin, a widely used antidiabetic drug, has been shown to improve bone quality and decrease the risk of fractures in patients with diabetes in addition to glycemic control and improving insulin sensitivity.
The use of medications like metformin can help keep your kidneys and other organs healthy over time.
Long-term side effects
Taking metformin can cause vitamin B12 deficiency if you take it for a long time. This can make you feel very tired, breathless and faint, so your doctor may check the vitamin B12 level in your blood. If your vitamin B12 levels become too low, vitamin B12 supplements will help.
Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood.
Griebeler says that even though metformin is only approved for the treatment of type 2 diabetes, it's being used off-label to treat weight reduction, polycystic ovarian syndrome (PCOS), infertility, prevention of diabetes, prevention of pregnancy complications, and obesity.
Conclusions: People with diabetes taking metformin were less likely to report back, knee, neck/shoulder and multisite musculoskeletal pain than those not taking metformin. Therefore, when treating these patients, clinicians should be aware that metformin may contribute to fewer reports of musculoskeletal pain.
24, 2022 (HealthDay News) -- People with type 2 diabetes might face a substantially increased risk of heart failure if they take ibuprofen or some other type of nonsteroidal anti-inflammatory drug (NSAID), a new Danish study indicates.
Nausea and diarrhea are common side effects of metformin, but they usually improve within a few weeks of starting the medication. You can limit these side effects by taking metformin with food. Metformin can cause more serious side effects like lactic acidosis, low vitamin B12 levels, and low blood sugar.
In contrast, metformin is known to have a neutral effect on body weight and was shown to reduce the amount of body fat and improve body composition in previous studies performed in type 2 diabetic patients [5, 6].
Metformin is a commonly used drug for treating patients with Type 2 diabetes. Extensive research has shown that metformin can also be used as an anti-aging therapy. For this reason, many people without diabetes, including Silicon Valley techies, take the inexpensive drug in the hopes it will keep them healthy longer.
Conclusions. Metformin attenuates osteoarthritis structural worsening and modulates pain, suggesting its potential for osteoarthritis prevention or treatment.
Chronic inflammation is a risk factor for both type 1 and type 2 diabetes, but it can also be a complication of diabetes. In the case of type 1 diabetes, inflammation is part of the autoimmune response that causes the disease.
But inflammation also affects our cells. It makes them insulin resistant, leading to chronically elevated blood sugar levels. Inflammation is often called a “silent” condition. This means it can develop unnoticed over time, contributing to chronic diseases like type 2 diabetes.
It is indicated that metformin has neuroprotective and anti-inflammatory effects, which attenuate neuropathic pain and hyperalgesia in injured nerves.