Researchers looked at data on statin use among 18,446 people, ages 65 or older, who had taken part in a large randomized trial of aspirin. The researchers found that over a follow-up period of almost five years, people who took statins weren't any more likely than non-users to have dementia.
In total, a pooled analysis of 36 studies found that statins were associated with a decreased risk of dementia (OR 0.80 (CI 0.75-0.86). For Alzheimer's disease, the association with statins based on 21 studies, was also reduced (OR 0.68 (CI 0.56-0.81).
Neurological side effects
The FDA warns on statin labels that some people have developed memory loss or confusion while taking statins. These side effects reverse once you stop taking the medication.
In the past there have been concerns that in the short-term statins might cause memory-loss and confusion, which has been widely reported in the media, but more recent studies have generally not found this link.
Evidence for Statins Increasing Risk of Dementia
Simvastatin, atorvastatin, and pravastatin were the medications taken by the patients who were described. About half of these patients noticed cognitive problems within two months of starting treatment.
Researchers looked at data on statin use among 18,446 people, ages 65 or older, who had taken part in a large randomized trial of aspirin. The researchers found that over a follow-up period of almost five years, people who took statins weren't any more likely than non-users to have dementia.
In some patients, a diagnosis of dementia or Alzheimer's disease was reportedly reversed upon discontinuation of the statin. Patients whose symptoms improved after discontinuation reproduced the symptoms after the statin was rechallenged.
Adults age 75 and older may not need statins.
Many older adults have high cholesterol. Their doctors usually prescribe statins to prevent heart disease. But for older people, there is no clear evidence that high cholesterol leads to heart disease or death.
High blood cholesterol can raise the risk of certain types of dementia, such as Alzheimer's disease and vascular dementia. However, cholesterol does not enter the brain, and researchers are unsure how these conditions are linked.
The good news for anyone who experiences cognitive decline related to starting statins? The brain fog goes away when you stop taking the drugs. Bottom line: If your brain tolerates statins, you don't need to worry about long-term cognitive decline as a possible side effect of these medications.
Results: Of the 60 patients identified who had memory loss associated with statins, 36 received simvastatin, 23 atorvastatin, and 1 pravastatin. About 50% of the patients noted cognitive adverse effects within 2 months of therapy. Fourteen (56%) of 25 patients noted improvement when the statin was discontinued.
Side effects can vary between different statins, but common side effects include: headache. dizziness.
The researchers found that anticholinergic drugs in general were associated with a higher risk of dementia. More specifically, however, anticholinergic antidepressants, antipsychotic drugs, anti-Parkinson's drugs, bladder drugs, and epilepsy drugs were associated with the highest increase in risk.
Statins should be taken with caution if you're at an increased risk of developing a rare side effect called myopathy, which is where the tissues of your muscles become damaged and painful. Severe myopathy (rhabdomyolysis) can lead to kidney damage. Things that can increase this risk include: being over 70 years old.
After having their cholesterol tested, seniors should be given a number between 190 and 260. Healthy seniors should keep their total cholesterol below 200 and their LDL cholesterol around 100. If your elderly loved one's LDL cholesterol level is above 160, he or she must start making sweeping lifestyle changes.
If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.
PCSK-9 inhibitors thus reduce cholesterol levels by maintaining higher levels of LDL receptors that remove cholesterol from the blood. Currently, PCSK-9 inhibitors are limited in use as they must be administered as shots. Further research into them could expand their use as an alternative to statins.
When people have high cholesterol their LDL (bad) is high and their HDL (good) is low. Eating healthy, regular exercise and drinking plenty of water will help to bring down cholesterol levels within 2-3 weeks.
While coffee does not contain cholesterol, it can affect cholesterol levels. The diterpenes in coffee suppress the body's production of substances involved in cholesterol breakdown, causing cholesterol to increase. Specifically, coffee diterpenes may cause an increase in total cholesterol and LDL levels.
Oatmeal, oat bran and high-fiber foods
Soluble fiber is also found in such foods as kidney beans, Brussels sprouts, apples and pears. Soluble fiber can reduce the absorption of cholesterol into your bloodstream. Five to 10 grams or more of soluble fiber a day decreases your LDL cholesterol.
Many animal studies have shown that statin administration reduces the formation of beta-amyloid plaques due to a reduction of cholesterol in the brain.
No association between statin use and decline in cognition over time was identified. No differences were found in any of the primary outcomes between users of hydrophilic versus lipophilic statins.
Psychiatric adverse effects, altering mood, personality, and behavior, sometimes arise in patients receiving statins. Statin psychiatric effects can include irritability/aggression, anxiety or depressed mood, violent ideation, sleep problems including nightmares, and possibly suicide attempt and completion.