Yes, it's common and often recommended to take antidepressants for 3 years or longer, especially for severe or recurrent depression, to prevent relapse, though the exact duration depends on individual history, with guidance suggesting 2 years to indefinite treatment for multiple episodes. Many people take them long-term, with over 60% taking them for over two years, but it's crucial to work with a doctor to weigh benefits against potential harms and discuss personalized tapering if stopping.
Long-Term Treatment – For those with severe, recurrent depression or treatment-resistant depression, antidepressants may be used for several years or indefinitely. The decision to remain on long-term medication depends on how well the medication controls symptoms and the patient's mental health history.
Those who had used antidepressants for >3 years reported more severe side effects, including “weight gain”, “addiction”, “feeling not like myself ”, “withdrawal symptoms”, and “suicidality”, than those who had been on antidepressants for ≤2 years.
In time, the brain returns to a normal state after stopping antidepressants. If depressive symptoms do arise and gradually worsen, it's best to consult a psychiatrist or doctor if they don't improve within a few weeks or if they become severe.
If you take antidepressants for a long time (several years or more) you may be at an increased risk of type 2 diabetes. This is more likely if you are over the age of 30 and are taking either SSRI or tricyclic antidepressants.
For people with chronic or severe depression, medication may be needed on a long-term basis. In these cases, antidepressants are often taken indefinitely. That is, in part, because depression is not an illness that can be cured.
The return of depression or anxiety usually takes longer – typically weeks or months. Some antidepressants, like fluoxetine, take a lot longer to leave the body. So, with these, symptoms can start days or even weeks after stopping or reducing your dose.
Antidepressants can have far-reaching effects on our brain functions. This can include changes to our cognition (how we think and understand), our emotions (how we feel), and our behavior (how we act).
However, some positive effects of withdrawal were also reported, such as people feeling like their emotions were returning to normal (rather than being 'blunted' by their medication). Some participants reported positive changes in their thinking patterns and found it easier to recall positive memories.
Types of natural antidepressants
There are many different options, like: Nutritional supplements: Omega-3 fatty acids (fish oil), SAMe and probiotics. Herbs and plant extracts: Saffron. Vitamins and minerals: B-vitamins (thiamine, L-methylfolate, B12), magnesium, vitamin D.
SSRIs are the most commonly prescribed type of antidepressant. This is because they're effective and well-tolerated with mild side effects for many people. With many SSRIs available as generic products, they also tend to be more affordable. SNRIs and bupropion are also common choices for similar reasons.
You are feeling better, and you and the doctor agree that it is time to stop. You have been taking the medicine for at least 6 months after you feel better. You are having counselling to help you cope with problems and help change how you think and feel. You are not worried about the depression coming back.
Antidepressant withdrawal symptoms were common, and severe and prolonged for a substantial proportion of users. Longer duration of use was associated with greater likelihood of severe and protracted symptoms and being less likely to be able to stop.
However, when compared with antidepressants, a recent 2022 network meta-analysis of randomized controlled trials found no difference between exercise and pharmacological interventions in reducing depressive symptoms in adults with nonsevere depression.
If you've had depression in the past, your doctor may recommend that you take antidepressants for 2 years. If your condition comes back, you may need to keep taking the medicine for life. If your illness is serious and the medicine works well for you, your treatment should continue.
Avoid driving or operating machinery. Avoid caffeine, tobacco and alcohol. Drink plenty of fluids. Take your antidepressant at bedtime if your doctor approves.
After discontinuing antidepressants, the brain undergoes a readjustment period as neurotransmitter levels and receptor sensitivity gradually return to their pre-treatment state.
The hardest antidepressants to come off are typically those with short half-lives, meaning they leave the body quickly, leading to more intense withdrawal (discontinuation syndrome); prominent examples include Paroxetine (Paxil), Venlafaxine (Effexor), and Fluvoxamine (Luvox), with Venlafaxine often cited for particularly severe withdrawal. In contrast, Fluoxetine (Prozac), with its long half-life, is generally considered the easiest to stop due to its gradual exit from the body.
The symptoms of depression can be complex and vary widely between people. If you're depressed, you may feel sad, hopeless and lose interest in things you used to enjoy. The symptoms persist for weeks or months and are bad enough to interfere with your work, social life and family life.
Despite the effects MDD has been shown to have on the brain, there is good news. “When depression is treated effectively, many people experience a resolution of the cognitive changes, suggesting that these changes may not be permanent,” Kristinsson says.
Antidepressants are thought to work by increasing neurotransmitters like serotonin and noradrenaline. These are chemicals in the brain which can improve mood and emotion. But this process isn't fully understood. Increasing levels of neurotransmitters can also disrupt pain signals sent by nerves.
While it is generally accepted that antidepressant medications are not addictive, they do have the potential to cause withdrawal symptoms when use is suddenly reduced or stopped. Most misuse or abuse of prescription antidepressants generally occurs as a result of polysubstance use. What Is Addiction?
Mental Clarity
Some people report positive changes in their thinking and cognitive abilities after stopping antidepressants. This can include improved memory, focus, and mental clarity. However, it is worth noting that taking antidepressants does not commonly affect cognitive abilities in most people.
Some antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), can cause short-term memory problems in certain individuals. Research shows that many people experience these side effects only while taking the medication, and the memory issues often go away when the treatment is adjusted or stopped.
What are the alternatives to antidepressants?