High blood pressure: Melatonin can raise blood pressure in people who are taking certain medications to control blood pressure. Avoid using it.
Melatonin Interactions With Blood Pressure Medications
Adalat, Cardiazem, Isoptin, Plendil, and more (calcium channel blockers): This class of drugs is often used to treat high blood pressure, angina (chest pain), and certain arrhythmias, states Dr.
Also, so-called cardiovascular events, including heart attacks and sudden cardiac death (unexpected death caused by a change in heart rhythm), occur at a higher rate in the early morning when melatonin is at its lowest. These studies strongly suggest that melatonin protects the heart and blood vessels.
The most commonly reported melatonin side effects include: Vivid dreams. Nightmares. Dizziness.
If melatonin does seem to help, it's safe for most people to take nightly for one to two months. “After that, stop and see how your sleep is,” he suggests. “Be sure you're also relaxing before bed, keeping the lights low and sleeping in a cool, dark, comfortable bedroom for optimal results.”
Bleeding disorders: Melatonin might make bleeding worse in people with bleeding disorders. Depression: Melatonin can make symptoms of depression worse. High blood pressure: Melatonin can raise blood pressure in people who are taking certain medications to control blood pressure. Avoid using it.
However, in the UK, Melatonin is not authorised to be sold without a prescription. This means that it's illegal to sell it in health food shops as Melatonin supplements, like Melatonin gummies. Any sale of Melatonin without a doctor's prescription is illegal in the UK because it's a prescription-only medicine.
Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively. The treatment did not affect heart rate. The day–night amplitudes of the rhythms in systolic and diastolic blood pressures were increased by 15% and 25%, respectively.
Melatonin's target sites are both central and peripheral. Binding sites have been found in many areas of the brain, including the pars tuberalis and hypothalamus, but also in the cells of the immune system, gonads, kidney, and the cardiovascular system (39, 40).
Melatonin can affect multiple cardiovascular functions, such as cardiac output, blood pressure, heart rate, and seasonal rhythms. The functions of melatonin are related to the activity of the melatonergic system and the suprachiasmatic nucleus (94).
Magnesium intake of 500 mg/d to 1000 mg/d may reduce blood pressure (BP) as much as 5.6/2.8 mm Hg. However, clinical studies have a wide range of BP reduction, with some showing no change in BP.
Melatonin is generally regarded as safe for seniors by physicians and pharmacists because its side effects are mild, it's not habit forming, and it does not cause withdrawal symptoms if you stop taking it suddenly. However, some of the side effects listed above may present additional challenges for older adults.
How Long Does Melatonin Stay in Your System? The half-life of melatonin is between 20 and 50 minutes, meaning half of the initial dosage in the body is eliminated after that amount of time. In total, melatonin stays in your system for about four to five hours.
The effects of melatonin on vascular function are complex; melatonin receptor activation causes vasoconstriction in some vasculatures and vasodilation in others. For instance, melatonin has been found to elicit vasoconstriction in certain arteries (Evans et al. 1992, Geary et al.
The NDPSC considered that insufficient information was available on the safety of melatonin to allow it to remain exempt from scheduling for human therapeutic use and that it should not be available without prescription.
Magnesium supplements are perhaps one of the most popular melatonin alternatives; for good reason. Magnesium is an essential trace mineral found in various amounts in many foods. As a dietary mineral, its key role is in enzyme reactions.
Dr Patels explains why this is: “We are regulated by the NHS, and the guidance from National Institute of Clinical Excellence (NICE) recommends the medication that doctors and GPs can prescribe, based on research and cost effectiveness. This is why [melatonin] is not as easily prescribed, or for prolonged periods."
Key takeaways: Melatonin is an over-the-counter supplement that's often used to help with sleep problems. There's no evidence that melatonin is harmful to your heart, liver, or kidneys.
A 2017 study indicated melatonin as an effective and safe option for treating people with anxiety following acute coronary syndrome (ACS). A 2018 study found that the administration of melatonin was more effective in improving anxiety and sleeping patterns than the drug oxazepam in people undergoing heart surgery.
You should not get any harmful discontinuation or withdrawal effects if you stop taking melatonin. However, you may get your old symptoms back. If you are on a high dose, then the doctor may wish to reduce the dose slowly before stopping it completely.
Taking too much melatonin can actually cause rebound insomnia —either rendering the supplement ineffective or worse, exacerbating your already sleepless nights further. You only need tiny doses of melatonin to support your natural sleep cycle.