Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
Short-acting statins are most effective when a person takes them at night, but a person can take long-acting statins at any time of the day. The most important point to remember is to take them every day, ideally at the same time. As with any medication, a person should take it according to their prescription.
There is a better time of day to take certain statins
And statins work by blocking cholesterol production in the liver. However, some statins last long enough in your body that they'll still be working at night, even if you take them in the morning. These statins can be taken at any time of day: Atorvastatin.
Accumulating databases from the US Food and Drug Administration Adverse Event Reporting System (FAERS) suggest that statin use is associated with an increased risk of sleep disturbances including insomnia [8]. In other studies hallucinations and nightmares during statin therapy were also observed [6, 7].
5. The cholesterol-lowering action of alternate-day statins is as effective as daily dosing in many individuals. 6. To maintain the same degree of decrease in LDL-C when giving the statins on alternate days, the dose of the statins frequently needs to be increased.
Statin Warning Signs
Examples of symptoms that might prompt you to see a doctor include: Excessive thirst or having to urinate frequently.
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake.
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.
Your doctor may recommend you take your statin at a certain same time every day as this keeps your blood levels even. If you forget to take your medication, take your regular dose the next day. Don't take extra of your medication.
Background: Adenosine receptor activation is essential for mediating the IS-limiting effects of statins. Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins.
Common side effects
dizziness. feeling sick. feeling unusually tired or physically weak. digestive system problems, such as constipation, diarrhoea, indigestion or farting.
Initial magnetic resonance imaging (MRI) studies of the aorta suggested that statin use might result in atherosclerotic plaque regression as early as 6 months after initiation of therapy [2].
Statins should not be taken if you have liver disease or if blood tests suggest that your liver may not be working properly. This is because statins can affect your liver, and this is more likely to cause serious problems if you already have a damaged liver.
Grapefruit juice is the only food or drink that has a direct interaction with statins.
These statins, including atorvastatin (Lipitor®), simvastatin (Zocor®) and fluvastatin (Lescol®), are more likely to cause muscle aches. The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause fewer muscle aches.
People who did take statins consumed more calories and fat over time, and gained more weight. The study also showed that statin users had a faster increase in body mass index (BMI) than those who didn't use statins.
In total, a pooled analysis of 36 studies found that statins were associated with a decreased risk of dementia (OR 0.80 (CI 0.75-0.86). For Alzheimer's disease, the association with statins based on 21 studies, was also reduced (OR 0.68 (CI 0.56-0.81).
Statins block an enzyme the liver needs to make cholesterol. This causes the liver to remove cholesterol from the blood. While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people. Rarely, they may cause liver damage.
The side effects of statins include diarrhoea and constipation, although no pathophysiological explanation is provided by the manufacturer. There are various mechanisms that have been postulated by which statins are thought to induce myotoxicity.
But parts of the cholesterol-synthesis pathway are needed for the GPCR signaling pathway to function, which explains the temporary negative side effects while taking statins, such as blurred vision or short-term memory loss.
We often tell patients to take statins in the evening because most cholesterol is produced at night. But this isn't always necessary. Lipitor, Crestor, and Pravachol can be taken at ANY time of the day.