Males have a slightly higher prevalence of Down syndrome than females, though it occurs in both genders, with some studies suggesting a higher rate in boys, especially with younger mothers, while older couples might see more girls. Overall, Down syndrome affects males and females relatively equally, but research points to a slight male predominance, potentially influenced by parental age, with more males born to younger parents and more females to older parents, according to some studies.
Global Down syndrome prevalence rate in 1990 and 2019, by gender. In 2019, the global age-standardized prevalence rate of Down syndrome was around 21.51 per 100,000 population. The prevalence rate of Down syndrome is slightly higher among males than females.
In a sample of 75 children with trisomy for chromosome 21, or Down syndrome, there were 42 males and 33 females. The sex ratio was 1.30 which is statistically not significant (p greater than 0.05).
Down syndrome occurs in people of all races and economic levels. The risk increases with the mother's age (1 in 1250 for a 25 year old mother to 1 in 1000 at age 31, 1 in 400 at age 35, and about 1 in 100 at age 40). However, 80% of babies with Down syndrome are born to women under age 35 years.
But most children with Down syndrome are born to pregnant people under age 35 because they have far more babies. Being carriers of the genetic translocation for Down syndrome. Either parent can pass the genetic translocation for Down syndrome on to their children. Having had one child with Down syndrome.
According to the World Health Organization, the highest prevalence of Down syndrome is reported in countries such as Ireland, Israel, and Turkey. In contrast, countries like Japan and South Africa report a lower incidence of Down syndrome.
This finding of the paternal age influence on Down syndrome suggests that there is a sperm contribution to the trisomy; increased paternal age may lead to an increased frequency of chromosome abnormalities in sperm, according to Dr. Fisch.
Fifteen to thirty percent of women with trisomy 21 are fertile and they have about 50% risk of having a child with Down syndrome. There are few case reports of a man with Down syndrome fathering a child. 1 Here, we are reporting a case of woman with Down syndrome, who had delivered a normal child. in 15 to 16 weeks.
By now, it's clear: Yes, people with Down syndrome can get married, and many already have. We've seen what dating, love, and commitment can look like when individuals are supported with respect, education, and high expectations. Love is not limited by diagnosis.
Family Planning
The intelligence quotient (IQ) among children with Down syndrome varies but averages about 50, compared with children in the general population, whose average IQ is 100. Children with Down syndrome often have delays in developing motor and language skills, but this is variable.
The risk of chromosomal abnormality increases with maternal age. The chance of having a child affected by Down syndrome increases from about 1 in 1,250 for a woman who conceives at age 25, to about 1 in 100 for a woman who conceives at age 40.
Today the average lifespan of a person with Down syndrome is approximately 60 years. As recently as 1983, the average lifespan of a person with Down syndrome was 25 years.
These top issues that married couples face are financial struggles, parenting conflict, and family drama. These 3 issues seem to be the normal issues presented in therapy and they are very common in my practice today.
While females with Down syndrome are reported to be fertile or subfertile, males are reported to be infertile. To date, there are reports of three pregnancies that were fathered by two male Down syndrome patients (1, 2). We report a case of a nonmosaic Down syndrome male who fathered a normal child.
Although women older than 35 years of age make up a small portion of all births6 in the United States each year, about one half of babies with Down syndrome are born to women in this age group. This likelihood increases as age increases.
It is well known that the extra chromosome 21 originates from the mother in more than 90% of cases, the incidence increases with maternal age and there is a high recurrence in young women.
The average IQ of a young adult with Down syndrome is 50, equivalent to the mental age of an 8- or 9-year-old child, but this number varies widely. At the same time, they enjoy a rich social and emotional awareness.
As the father grows older, the number of mutations in the father's genome increases, leading to an increase in the incidence of congenital malformations in offspring [11, 65]. Older paternal age may be harmful to the offspring's health in terms of genetic mutations, telomere length, and epigenetics [66].
Down syndrome is caused by the presence of an extra chromosome number 21 in the cells of the developing baby. In an unscreened population, about one in every 700 babies is born with Down syndrome. Usually, it is not inherited, so a baby can be affected even if there is no history of Down syndrome in the family.
While a man with zero sperm count cannot achieve pregnancy through natural conception, there are still advanced reproductive technologies and treatments that can offer alternative paths to fatherhood, depending on the underlying cause of the condition.
Mosby's Medical, Nursing and Allied Health Dictionary gives an average IQ of between 50 and 60 for Down's syndrome individuals although IQ scores of 120 have been found in some individuals with the syndrome.
For instance, women of Asian descent have a lower risk of having a baby with Down syndrome compared to women of European descent. Overall, while Down syndrome is relatively rare, it remains an important health concern that affects many families and communities around the world.
Since the introduction of screening, Down syndrome pregnancies are often aborted (rates varying from 50 to 85% depending on maternal age, gestational age, and maternal race/ethnicity). There is no cure for Down syndrome. Education and proper care have been shown to provide better quality of life.
Down syndrome is a lifelong condition, and there isn't a cure. Symptoms of the condition are manageable, and treatment is available for any associated conditions that may arise.