Bone pain can occur in leukemia patients when the bone marrow expands from the accumulation of abnormal white blood cells and may manifest as a sharp pain or a dull pain, depending on the location. The long bones of the legs and arms are the most common location to experience this pain.
The nature of the discomfort can vary; some patients report sharp pain while others liken it to a dull, continuous ache. What bones hurt with leukemia? Bone pain symptoms tend to develop in areas of the body with bones that contain a large amount of bone marrow, such as the: Breastbone (sternum)
Common leukemia signs and symptoms include: Fever or chills. Persistent fatigue, weakness. Frequent or severe infections.
An overcrowding of cancerous, leukaemia cells in the bone marrow can also cause anaemia by preventing the bone marrow from efficiently producing red blood cells. A deficiency of red blood cells means there is less oxygen being carried muscles around the body, causing muscle cramps and aches.
Some signs of leukemia, like night sweats, fever, fatigue and achiness, resemble flu-like symptoms. Unlike symptoms of the flu, which generally subside as patients get better, leukemia symptoms generally last longer than two weeks, and may include sudden weight loss, bone and joint pain and easy bleeding or bruising.
When is a patient tested for leukemia? "A patient may be tested for leukemia if he or she has unexplained weight loss, night sweats or fatigue, or if he or she bruises or bleeds easily," Dr. Siddon says. "Sometimes routine blood work shows an unexplained elevated number of white blood cells."
Leukemia is commonly misdiagnosed as the following conditions: Influenza. Fever. Pathological fracture.
Chronic Leukemia May Go Undetected
It may take months or even several years before the disease begins to cause symptoms that alert the patient that something is wrong.
Leukemia starts in the soft, inner part of the bones (bone marrow), but often moves quickly into the blood. It can then spread to other parts of the body, such as the lymph nodes, spleen, liver, central nervous system and other organs.
Chronic leukemia often causes only a few symptoms or none at all. Signs and symptoms usually develop gradually. People with a chronic leukemia often complain that they just do not feel well. The disease is often found during a routine blood test.
Often referred to as a “silent disease,” CLL can be difficult to diagnose, because people often don't have any symptoms until later in the disease, and others have symptoms that resemble signs of other conditions, such as a cold.
Blood tests.
By looking at a sample of your blood, your doctor can determine if you have abnormal levels of red or white blood cells or platelets — which may suggest leukemia. A blood test may also show the presence of leukemia cells, though not all types of leukemia cause the leukemia cells to circulate in the blood.
Stage 1 – A patient has high levels of white blood cells and enlarged lymph nodes. Stage 2 – A patient has high levels of white blood cells and is anemic. He or she may also have enlarged lymph nodes. Stage 3 – A patient has high levels of white blood cells and is anemic.
Bone and joint pain are seen as presenting symptoms in 25% of patients with acute leukemia, but generalized osteopenia and vertebral complications are less common. Back pain due to vertebral changes as an early feature has been infrequently reported.
People often feel ill quite quickly. Most symptoms of acute leukaemia are caused by leukaemia cells filling the bone marrow. This means healthy blood cells do not move into the blood as normal.
Here is a list of some symptoms you might have if you have cancer related fatigue: lack of energy – you may just want to stay in bed all day. feeling you just cannot be bothered to do much. sleeping problems such as unable to sleep or disturbed sleep.
They occur in unusual places – In cases of leukaemia, quite often bruises will appear in places that you wouldn't normally expect, especially; the back, legs, and hands.
While the exact cause of leukemia—or any cancer, for that matter—is unknown, there are several risk factors that have been identified, such as radiation exposure, previous cancer treatment and being over the age of 65.
Your doctor will conduct a complete blood count (CBC) to determine if you have leukemia. This test may reveal if you have leukemic cells. Abnormal levels of white blood cells and abnormally low red blood cell or platelet counts can also indicate leukemia.
Infections and Fevers
Your blood cells help your immune system function. When these cells are unhealthy, your body's immune system can't function normally causing you to get sick more often. One of the most common first symptoms of leukemia is frequent fevers and infection.
Age: The risk of most leukemias increases with age. The median age of a patient diagnosed with acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) or chronic myeloid leukemia (CML) is 65 years and older. However, most cases of acute lymphocytic leukemia (ALL) occur in people under 20 years old.
Myelodysplastic syndrome refers to a group of related disorders in which abnormal blood-forming cells develop in the bone marrow. At first, these cells interfere with the production of normal blood cells. Later, these cells may become cancerous, turning into a form of leukemia .
Chronic lymphocytic leukemia (CLL)
CLL develops when too many abnormal lymphocytes grow, crowding out normal blood cells and making it difficult for the body to fight infection.
During the progression of leukemia, white blood cells (neoplastic leukocytes) found in bone marrow may begin to filter into the layers of the skin, resulting in skin lesions. “It looks like red-brown to purple firm bumps or nodules and represents the leukemia cells depositing in the skin,” Forrestel says.