Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. It is the most common type of acute leukemia in adults. This type of cancer usually gets worse quickly if it is not treated.
Because of advances in diagnosis and treatment of this disease, APL is now considered the most curable form of adult leukemia. Cure rates of 90 percent have been reported from centers specializing in APL treatment.
Acute myeloid leukemia (AML) is the most fatal type of leukemia. The five-year survival rate (how many people will be alive five years after diagnosis) for AML is 29.5%. Leukemia is a cancer that usually affects white blood cells, though it can start in other types of blood cells.
Chronic lymphocytic leukemia (CLL) can rarely be cured. Still, most people live with the disease for many years. Some people with CLL can live for years without treatment, but over time, most will need to be treated. Most people with CLL are treated on and off for years.
The slow-growing form of chronic lymphocytic leukemia (CLL) is the least serious type of leukemia. It is a disease of older people; the average age at diagnosis is around 71. CLL is a malignancy of mature lymphocytes, which usually grow and divide slowly, resulting in a slowly progressive disease.
Chemo treatment for ALL is typically divided into 3 phases: Induction, which is short and intensive, usually lasts about a month. Consolidation (intensification), which is also intensive, typically lasts for a few months. Maintenance (post-consolidation), which is less intensive, typically lasts for about 2 years.
Key points – emergencies in leukemia
The high risk of bleeding in uncontrolled acute promyelocytic leukemia (APML) represents a medical emergency. To prevent coagulopathy, anti-leukemic therapy should be initiated as soon as possible alongside meticulous supportive care.
Chronic leukemia usually gets worse slowly, over months to years, while acute leukemia develops quickly and progresses over days to weeks. The two main types of leukemia can be further organized into groups that are based on the type of white blood cell that is affected — lymphoid or myeloid.
Chronic leukemia inhibits the development of blood stem cells, ultimately causing them to function less effectively than healthy mature blood cells. As compared to acute leukemia, chronic leukemia tends to be less severe and progresses more slowly.
Biopsy. A biopsy is used to determine the type of leukemia, the growth rate of the tumor, and whether the disease has spread. Common biopsy procedures for leukemia include: Bone marrow biopsy removes a sample of bone marrow.
Chronic leukemia involves more-mature blood cells. These blood cells replicate or accumulate more slowly and can function normally for a period of time. Some forms of chronic leukemia initially produce no early symptoms and can go unnoticed or undiagnosed for years.
Leukemia occurs when one type of immature blood cell mutates and begins growing uncontrollably. The overgrowth of one type of blood cell crowds out the others, causing a range of symptoms. Leukemia can develop at any age.
Chronic myeloid leukaemia (CML) is a type of cancer that affects the white blood cells and tends to progress slowly over many years. It can occur at any age, but is most common in older adults around 60-65 years of age.
Acute leukemia symptoms can often appear suddenly
With acute leukemia, symptoms tend to develop very quickly. You may suddenly spike a fever that won't go away, develop an infection for no apparent reason, or start bleeding spontaneously from your nose or gums and not be able to stop it.
Leukemia starts in the soft, inner part of the bones (bone marrow), but often moves quickly into the blood. It can then spread to other parts of the body, such as the lymph nodes, spleen, liver, central nervous system and other organs.
AML is more common in older adults because it's often caused by genetic mutations. These mutations may not cause cancer at first, but they can build up over time and lead to acute leukemia. Chronic leukemias are more commonly diagnosed in older adults, mainly because they don't often cause symptoms in early stages.
However, there are many varieties of leukemia, not all of which are threatening. Chronic lymphocytic leukemia is, in general, one of those nonthreatening leukemias.
Patients will often need to stay in the hospital for 3 to 4 weeks during treatment. However, depending on the situation, many patients can leave the hospital. Those who do, usually need to visit the doctor regularly during treatment.
The treatment usually consists of four cycles of intensive chemotherapy that includes high doses of cytarabine and one or more other drugs.
First phase — induction chemotherapy. Second phase — consolidation chemotherapy. Third phase — maintenance chemotherapy. Fourth phase — central nervous system (CNS) prophylaxis.
A return to normalcy is typical, but it takes a while – usually six months or so. “All who have done chemo do finally get back to normal,” Patricia said.