“Take water-soluble vitamins on an empty stomach with a glass of water,” recommends Dr. Perez-Gallardo. And since it can be energizing, Dr. Perez-Gallardo says that the best time to take vitamin B12 is in the morning, so it won't affect your sleep.
According to health experts at Click Pharmacy, as a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
Can You Take Vitamin B12 on an Empty Stomach? Vitamin B12 is water-soluble, which means you can take it with or without food. (Water-soluble vitamins don't require fat content to aid absorption.) If you have a sensitive stomach, however, we do recommend taking supplements with food.
It's best to take vitamin B12 in the morning away from food to maximize absorption, as certain nutrients can inhibit it. However, vitamin B12 can be taken with food. Just ensure you're not dealing with any nutrient interactions.
Vitamin B12 works on the pineal gland, which is responsible for the production of melatonin. The vitamin helps increase the production of melatonin during the nighttime hours, as well as release it earlier, making it easier to fall and stay asleep.
Vitamin B-12 has a big role in stabilizing your energy levels. It actually helps give you more energy, rather than making you tired. If you do notice feeling a little fatigued, even though you're regularly taking a B-12 supplement, it's likely a sign of something else that is out of the norm in your body.
Taking vitamin B-12 with vitamin C might reduce the available amount of vitamin B-12 in your body. To avoid this interaction, take vitamin C two or more hours after taking a vitamin B-12 supplement.
Fat-soluble and water-soluble vitamins
For example, although it's safe to take vitamin D with vitamin B12, it's not advisable, says Virgilio Sanchez, MD, a board certified family medicine physician at Conviva Care Center in Miami, Florida.
Take this medication by mouth with or without food as directed by your doctor or the product package, usually once daily. Use this product regularly to get the most benefit from it. To help you remember, take it at the same time each day.
No interactions were found between caffeine and Vitamin B12.
Vitamin B12 is an essential nutrient. Fish, shellfish, meat, eggs, and dairy products are good sources of vitamin B12. The amount that should be consumed on a daily basis is called the recommended dietary allowance (RDA). The RDA is 2.4 mcg daily for people 18 years and older.
Can I take magnesium and vitamin B together? Yes, as B vitamins and magnesium don't compete for absorption inside your body. Indeed, many supplements combine them as a way of simplifying how you monitor your intake.
B12 also plays a role in the production of melatonin, a hormone that helps regulate our circadian rhythms. It is possible that a deficiency of B12 could lead to disrupted sleep patterns. Vitamin B12 also helps in the production of energy.
Due to its special role, vitamin B12 aids in the prevention of anemia, which mostly leads to fatigue. Even though the research available about the relationship between vitamin B12 and insomnia remains unclear, some studies² show that elevated levels of vitamin B12 do cause sleeplessness.
Final Thoughts. Although there are no guidelines suggesting the recommended time to take vitamin B12, and there is no clinical evidence showing a link between B12 supplementation at night and sleep disruption, it does have the potential to disrupt sleep.
Fatigue. Megaloblastic anemia due to vitamin B-12 deficiency may lead to a person feeling fatigued. Without enough red blood cells to carry oxygen around their body, a person can feel extremely tired.
There are certain foods that also need a cut-down in case of vitamin B12 deficiency. “Some foods and drinks can interfere with vitamin B complex intake like alcohol, caffeine and processed foods, etc should be avoided completely,” Shah added.
Stage 1 is decreased levels of vitamin B12 in the blood. Stage 2 is low concentration of vitamin B12 in the cell and metabolic abnormalities. Stage 3 is increased levels of homocysteine and MMA and decreased DNA synthesis resulting in neuropsychiatric symptoms. Stage 4 is macrocytic anemia.
Vitamin B12 deficiency can indeed lead to weight gain. But the weight gain is not a direct result of the deficiency. Instead, vitamin B12 deficiency causes lethargy or lack of energy, and in turn, inactivity causes weight gain. When you lack the energy to move, you don't burn fat.
Don't use calcium, zinc, or magnesium supplements at the same time. Also, these three minerals are easier on your tummy when you take them with food, so if your doctor recommends them, have them at different meals or snacks.
As summarized in the table provided, vitamin B12 (cobalamin) absorption and utilization by the body can be compromised with the chronic use of certain medications which include: colchicine, chloramphenicol, ethanol, histamine 2 receptor antagonists (H2RA), metformin, and proton pump inhibitors (PPI).
If you are an older adult, you should be taking a supplement for B12 as well as trying to incorporate B12 into your diet. It is vital for good health and cognitive functioning. Studies continue to show all the ways it is beneficial for your overall health.