Magnetic resonance imaging (MRI)
It's very accurate and can pinpoint the exact location and size of any inflammation, damage or scarring (lesions). MRI scans confirm a diagnosis in over 90 per cent of people with MS.
They'll also look for signs of MS, such as: elevated levels of antibodies called IgG antibodies. proteins called oligoclonal bands. an unusually high number of white blood cells.
People should consider the diagnosis of MS if they have one or more of these symptoms: vision loss in one or both eyes. acute paralysis in the legs or along one side of the body. acute numbness and tingling in a limb.
While there is no definitive blood test for MS, blood tests can rule out other conditions that cause symptoms similar to those of MS, including lupus erythematosis, Sjogren's, vitamin and mineral deficiencies, some infections, and rare hereditary diseases.
There is no definite measure or laboratory marker for the diagnosis of MS, yet. Both the clinical features of the disease, and laboratory investigations such as magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) analyses are being used.
These include imaging techniques such as magnetic resonance imaging (MRI), spinal taps (examination of the cerebrospinal fluid that runs through the spinal column), evoked potentials (electrical tests to determine if MS affects nerve pathways), and laboratory analysis of blood samples.
Numbness of the face, body, or extremities (arms and legs) is often the first symptom experienced by those eventually diagnosed as having MS.
The first step in diagnosing MS is taking a thorough medical history. Your doctor will ask you about your symptoms, including when they began and whether you've noticed any patterns or triggers. They may also ask you about: injuries, diseases, or other health conditions with which you've been diagnosed.
MS is best detected by a neurological examination and painless imaging studies of the brain and spinal cord using magnetic resonance testing (MRI). An ophthalmologist also can use a test called an optical coherence tomography (OCT) to determine if the optic nerve has been affected by MS.
Diagnosis and early intervention
As optic neuritis is the presenting sign of MS in up to 30 percent of patients, the eye exam can lead to the initial systemic diagnosis.
Early signs and symptoms of MS
tingling and numbness. pains and spasms. weakness or fatigue. balance problems or dizziness.
Vision problems, like blurred or double vision. Dizziness and a lack of coordination. Trouble walking, feeling unsteady, a loss of balance.
MRI scan. An MRI scan is a painless scan that uses strong magnetic fields and radio waves to produce detailed images of the inside of the body. It can show whether there's any damage or scarring of the myelin sheath (the layer surrounding your nerves) in your brain and spinal cord.
Vision problems are an early sign of MS. Gait and mobility changes: MS can change the way people walk due to muscle weakness and problems with balance, dizziness, and fatigue. Emotional changes and depression: Demyelination and nerve fiber damage in the brain can trigger emotional changes.
Neuropathic pain happens from “short circuiting” of the nerves that carry signals from the brain to the body because of damage from MS. These pain sensations feel like burning, stabbing, sharp and squeezing sensations. In MS you can experience acute neuropathic pain and chronic neuropathic pain.
IgG index is used a marker of intrathecal production of immunoglobulins. A value of IgG index > 0.7 is an indicator of an increased intrathecal B cell response and thus indicates the presence of MS [18]. About 70% of MS patients have an increased IgG index [59, 60].
Inflammation in a myelinated portion of the nervous system is the mainstay of multiple sclerosis (MS). Elevation of inflammatory markers such as procalcitonin, ESR and hs-CRP is suspected to occur in MS patients.
A blood test that is positive for antinuclear antibodies and other antibodies may indicate lupus or some other autoimmune disease but not MS.
People with multiple sclerosis (MS) tend to have their first symptoms between the ages of 20 and 40. Usually the symptoms get better, but then they come back. Some come and go, while others linger. No two people have exactly the same symptoms.
Lesions may be observed anywhere in the CNS white matter, including the supratentorium, infratentorium, and spinal cord; however, more typical locations for MS lesions include the periventricular white matter, brainstem, cerebellum, and spinal cord.
Floaters are a common ocular symptom for individuals with multiple sclerosis, but MS isn't a leading cause. On their own, floaters don't usually indicate serious conditions. Eye conditions like optic neuritis can be an early warning sign of oncoming multiple sclerosis.