He lists 36 organ tissues in the body whose cells respond biologically to vitamin D. The list includes bone marrow, breast, colon, intestine, kidney, lung, prostate, retina, skin, stomach and the uterus. According to Norman, vitamin D deficiency can impact all 36 organs.
Due to the weakening of bones, individuals with low vitamin D levels are more prone to falling. Low vitamin D levels can also cause a poorly functioning immune system, cardiovascular disease, depression, development of diabetes, and multiple sclerosis. It has also been linked to certain types of cancer.
Vitamin D can affect the liver function through the vitamin D receptor (VDR). VDR is naturally present in the liver cells and its higher expression can reduce inflammation in chronic liver diseases (Benetti et al., 2018). Vitamin D also has anti−fibrotic, proliferative, and inflammatory effects on the liver.
Vitamin D deficiency has been frequently reported in many causes of chronic liver disease and has been associated with the development and evolution of non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) virus infection.
New evidence suggests that low serum Vitamin D may cause nonalcoholic fatty liver disease (NAFLD). Hypovitaminosis D is associated with the severity and incidence of NAFLD.
The kidneys have an important role in making vitamin D useful to the body. The kidneys convert vitamin D from supplements or the sun to the active form of vitamin D that is needed by the body.
In sum, multiple (but not all) studies have shown that low levels of 25(OH)D appear to be associated with a faster progression of kidney disease. In the KNHANES study, extremely low 25(OH)D levels in relatively healthy adults were associated with renal hyperfiltration, which likely causes further damage to the kidney.
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
Vitamin D deficiency can cause a number of neurological problems, including fatigue, memory loss, and difficulty concentrating. This means having a vitamin D deficiency treated with a supplement can possibly help improve your concentration levels.
The most serious complications of vitamin D deficiency are low blood calcium (hypocalcemia), low blood phosphate (hypophosphatemia), rickets (softening of the bones during childhood), and osteomalacia (softening of the bones in adults).
“Adding an over-the-counter vitamin D supplement can make improvements in just three to four months time. Vitamin D with a strength of 1000-2000 international units daily is the recommended dose for most adults,” Dr.
According to the National Library of Medicine, vitamin D deficiency can lead to a loss of bone density, which can contribute to osteoporosis and fractures (broken bones). Severe vitamin D deficiency can also lead to other diseases.
Left untreated, vitamin D deficiency can lead to osteoporosis in adults, rickets in children and adverse outcomes in pregnant women. It may also be linked to heart disease, diabetes and cancer — although more study is needed on the topic.
Having inadequate levels of vitamin D may correlate with unintentional weight gain. A study on women over the age of 65 found that participants with a lower vitamin D level experienced more weight gain.
For your kidneys to stay in the best condition possible, certain vitamins are essential. These vitamins are vitamin A, D, E, K, C, niacin, folic acid, B-complex vitamins, B5, and biotin. People with chronic kidney disorders can also take these vitamins to improve their health.
Vit D deficiency may exacerbate protein uric and DN, hence correction of Vit D deficiency may decrease proteinuria in diabetic patients with nephropathy.
Without Vitamin D, our bodies cannot effectively absorb calcium, which is essential to good bone health. Children who lack Vitamin D develop a condition called rickets, which causes bone weakness, bowed legs, and other skeletal deformities, such as stooped posture.
Conventional doses of vitamin D are well tolerated without appreciable adverse effects. High doses of vitamin D can be toxic, leading to a constellation of signs and symptoms but not liver injury or jaundice.
Vitamin D deficiency is a well reported complication in chronic cholestatic liver disease such as primary biliary cirrhosis. While the prevalence and treatment of this deficiency has been addressed in many articles over the last decades, little is known of the vitamin D status in alcoholic liver cirrhosis.
Furthermore, Vitamin D deficiency leads to dysbiosis of gut microbiome and reported to cause severe colitis. Vitamin D supplementation is low cost and available and can be a therapeutic option.