Every organ in the body, especially the heart, muscles, and kidneys, needs the mineral magnesium. It also contributes to the makeup of teeth and bones. Magnesium is needed for many functions in the body. This includes the physical and chemical processes in the body that convert or use energy (metabolism).
Magnesium is needed for more than 300 biochemical reactions in the body. It helps to maintain normal nerve and muscle function, supports a healthy immune system, keeps the heartbeat steady, and helps bones remain strong. It also helps adjust blood glucose levels. It aids in the production of energy and protein.
Magnesium plays many crucial roles in the body, such as supporting muscle and nerve function and energy production. Low magnesium levels usually don't cause symptoms. However, chronically low levels can increase the risk of high blood pressure, heart disease, type 2 diabetes and osteoporosis.
Magnesium Balance
The levels are regulated primarily in the kidney at the level of renal tubular reabsorption. Instead, control seems to be as fluxes at the intestine, kidney, intracellular fluids and perhaps the skeleton. The kidney is the prime regulator of serum Mg concentration.
Make sure you consult with your doctor if you are thinking of taking a magnesium supplement, as it's possible to take too much magnesium. Taking more than the recommended dose can cause vomiting, diarrhoea, abdominal cramps and, in extreme cases, irregular heartbeat and cardiac arrest.
People with diabetes, intestinal disease, heart disease or kidney disease should not take magnesium before speaking with their health care provider. Overdose. Signs of a magnesium overdose can include nausea, diarrhea, low blood pressure, muscle weakness, and fatigue. At very high doses, magnesium can be fatal.
Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk.
Magnesium supplements can cause excessive accumulation of magnesium in the blood, especially with patients who have chronic kidney disease. Accumulation of magnesium in the blood can cause muscle weakness, but does not damage the kidney directly.
Every organ in the body, especially the heart, muscles, and kidneys, needs magnesium. This mineral also contributes to the makeup of teeth and bones.
Causes of low magnesium. Low magnesium is typically due to decreased absorption of magnesium in the gut or increased excretion of magnesium in the urine. Low magnesium levels in otherwise healthy people are uncommon. This is because magnesium levels are largely controlled by the kidneys.
Twitches, tremors, and muscle cramps are signs of magnesium deficiency. In worst-case scenarios, deficiency may even cause seizures or convulsions ( 1 , 3 ). Scientists believe these symptoms are caused by a greater flow of calcium into nerve cells, which overexcites or hyperstimulates the muscle nerves (4).
Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.
From a neurological standpoint, magnesium plays an essential role in nerve transmission and neuromuscular conduction. It also functions in a protective role against excessive excitation that can lead to neuronal cell death (excitotoxicity), and has been implicated in multiple neurological disorders.
More than half of the magnesium in our body is stored in bones, and the remaining in various tissues throughout the body.
Magnesium levels between 7 and 12 mg/dL can impact the heart and lungs, and levels in the upper end of this range may cause extreme fatigue and low blood pressure. Levels above 12 mg/dL can lead to muscle paralysis and hyperventilation. When levels are above 15.6 mg/dL, the condition may result in a coma.
Magnesium status is closely linked with liver function. Liver diseases have a significant effect on body magnesium content, and magnesium levels in turn influence these disease processes.
Conclusion: This study suggests that high intake of magnesium may be associated with reduced risks of fatty liver disease and prediabetes.
Magnesium also helps prevent diabetes, cardiovascular disease, hypertension, and inflammation, all of which are contributing factors in kidney disease. Magnesium citrate has an alkalising effect on the body which is why we recommend it for kidney disease.”
Magnesium deficiency is known to be associated with hypertension, insulin resistance, and endothelial dysfunction, common risk factors that contribute to the progression of CKD. Lower serum magnesium levels are associated with an increased risk of both incident CKD and progression to end-stage kidney disease.
More than being regulated by intestinal absorption, magnesium homeostasis is governed by reabsorption of magnesium from primary urine in the kidney. Of about 2,400 mg magnesium that is being ultra-filtrated daily, 95-99% must be reabsorbed by the nephrons.
The kidney is a key regulator of Mg balance; 70% of the circulating Mg is filtered by the glomerulus, which accounts for 2,400 mg. Approximately 90–95% of filtered Mg is reabsorbed.
Doses less than 350 mg daily are safe for most adults. In some people, magnesium might cause stomach upset, nausea, vomiting, diarrhea, and other side effects. When taken in very large amounts (greater than 350 mg daily), magnesium is POSSIBLY UNSAFE.
Magnesium can decrease the absorption and effectiveness of numerous medications, including some common antibiotics such as tetracycline (Achromycin, Sumycin), demeclocycline (Declomycin), doxycycline (Vibramycin), minocycline (Minocin), ciprofloxacin (Cipro), levofloxacin (Levaquin), moxifloxacin (Avelox) and ofloxacin ...
Magnesium plays many crucial roles in the body, such as supporting muscle and nerve function and energy production. Low magnesium levels usually don't cause symptoms. However, chronically low levels can increase the risk of high blood pressure, heart disease, type 2 diabetes and osteoporosis.