B vitamins are important for making sure the body's cells are functioning properly. They help the body convert food into energy (metabolism), create new blood cells, and maintain healthy skin cells, brain cells, and other body tissues.
B vitamins act as coenzymes in several enzymatic processes that support every aspect of cellular physiological functioning, including major functions within the brain and nervous system.
The common forms of vitamin B include vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B6 (pyridoxine) and B12 (cyanocobalamin). Except for niacin (when given in high doses), there is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.
Since vitamin B12 is a water-soluble vitamin, the kidney does its job of removing extra B12. A high level of B12 in your body could indicate kidney illness. This means that the kidney isn't able to remove all of the excess B12 from the body.
The consequences and severity of B12 deficiency are variable depending on the degree of deficiency and its duration. Major organ systems affected include the blood, bone marrow and nervous system. Megaloblastic anemia results from a defect in thymidine and therefore DNA synthesis in rapidly dividing cells.
Normally, vitamin B12 is readily absorbed in the last part of the small intestine (ileum), which leads to the large intestine.
In diabetes patients with advanced kidney disease, high daily doses of B vitamins (folate, B6 and B12) were found in one study to worsen kidney function and double the risk of heart attack stroke and death (see the Cautions section of the B Vitamins Review for more information).
A high-dose B complex supplement (with 1,000 mcg of B-12) hurt, rather than helped, people with type 1 or type 2 diabetes and advanced kidney disease, resulting in a worsening of kidney function and an increase in the risk of heart attack, stroke and death.
The Framingham Heart Study found that elevated B12 at baseline was associated with two different markers of impaired kidney function: albuminuria and reduced glomerular filtration.
The findings from this research suggest that vitamin B12 and folic acid may have the potential to positively impact liver health, specifically when it comes to individuals with fatty liver disease. These particular nutrients, in the form of supplements, may even hold the possibility of reversing fatty liver disease.
Dietary intakes of vitamin B12 were also found increase in patients with NAFLD compared with controls in 101 Canadians (42) and 120 adult Jordanians (43), which were consistent with our main result that elevated vitamin B12 was causally associated with the increased risk of NAFLD.
Vitamin B12 for Fatty Liver Disease
The researchers also found that supplementing with vitamin B12 and folic acid increased levels of syntaxin 17 in the liver, restoring its role of digesting fat and protecting against inflammation.
Some of the negative side effects of vitamin B overdose include mood swings, restlessness, depression, and panic attacks. Mood swings can worsen in people who suffer from paranoia, confusion, or mental fogginess; due to the high doses of vitamin B complex.
You can't overdose on B vitamins, they're water soluble, so make sure you take a good B Complex vitamin and do that every day. The B Complex vitamin we have, this B Complex itself has close to 300 mg in a dose. 300 mg twice a day would be a great recommendation.
Therefore, B vitamins are essential not only for the host but also for the bacteria living in the gut. A dietary supply of these vitamins is essential to meet the host's daily requirements. B vitamins play crucial roles in shaping the diversity and richness of the gut microbiota.
You might get frequent headaches if your vitamin B12 levels are too high. Elevated levels of this vitamin can also cause gastrointestinal problems such as diarrhea, nausea, and vomiting. You may feel tired and weak.
In conclusion, unexplained elevated B12 levels should be examined as a possible marker of solid cancer.
An overdose of Vitamin B complex usually occurs from the excessive consumption of supplements, The complications that one notices in case of an overdose are skin rashes, insomnia, gastrointestinal problem, Tingling and numbness, Extreme mood swings, and abnormal blood pressure levels.
You may need to avoid some vitamins and minerals if you have kidney disease. Some of these include vitamins A, E and K. These vitamins are more likely to build up in your body and can cause harm if you have too much. Over time, they can cause dizziness, nausea, and even death.
What Causes Vitamin B Deficiency? Here's a roundup of 4 of the top causes of vitamin B deficiency: a non-balanced diet, excessive alcohol consumption, various medications (such as proton-pump inhibitors, or PPIs), and gut malabsorption conditions.
Vitamin deficiencies are a common cause of paresthesias. The B vitamins — vitamin B12 and vitamin B6 — are the most common ones. Deficiencies in copper, calcium, and magnesium can also lead to tingling in your hands and feet. Most of the time, correcting the deficiency can help reverse the symptoms.
Anticonvulsants -- include phenytoin (Dilantin), phenobarbital, primidone (Mysoline) Chemotherapy medications -- particularly methotrexate. Colchicine -- used to treat gout. Bile acid sequestrants -- used to lower cholesterol; include colestipol (Colestid), cholestyramine (Questran), and colsevelam (Welchol)