Liver transplantation is an ultra-major operation and probably the most difficult of all transplant operations. The hospital mortality rate after liver transplantation has ranged from 2% to 16% 1, 2, 3, 4, 5, 6, most series reporting a rate of about 10%.
Infections continue to be one of the main complications that can contribute to the patient's death. More than half of transplanted patients have at least one infections complication and an infection is responsible of more than half of the deaths in liver transplant recipients.
In summary, the leading causes of late deaths after transplant were graft failure, malignancy, cardiovascular disease and renal failure. Older age, diabetes, and renal insufficiency identified patients at highest risk of poor survival overall.
On average, most people who receive LT live for more than 10 years. Many may live for up to 20 years or more after the transplant. A study says 90% of people with transplant survive for at least 1 year, and 70% of people may live for at least 5 years after transplant.
It is a major operation and comes with surgical risks, like bleeding. Infections and bile duct complications are common after a liver transplant. You will need to take strong medicines to suppress your immune system. You may need further surgery to fix any problems.
The majority of the studies reported hospital mortality less than 11.1 %. The overall survival after hepatic resection were 45 to 99 % (1 year), 17 to 84.2 % (3 years), and 10 % to 65 % (5 years).
Chronic rejection usually leads to the loss of bile ducts (ductopenia). Another liver transplant may be needed. Rejection is suspected when the liver starts to work less well.
Liver transplant survival rates
In general, about 75% of people who undergo liver transplant live for at least five years. That means that for every 100 people who receive a liver transplant for any reason, about 75 will live for five years and 25 will die within five years.
Liver failure
There is a risk that your remaining liver doesn't work after your operation. This is a rare but serious complication and can be life threatening.
Graft failure
It's one of the most serious complications of a liver transplant and occurs in around 1 in every 10 people. The most common cause is a disruption to the blood supply to the transplanted liver, caused by blood clots (thrombosis). Graft failure can develop suddenly, or slowly over a longer period of time.
Variceal hemorrhage is the most lethal complication of cirrhosis[133].
Liver transplants are generally very successful and most people are eventually able to return to their normal activities afterwards. It can take a year or more to fully recover.
Acute rejection happens when your body's immune system treats the new organ like a foreign object and attacks it. We treat this by reducing your immune system's response with medication. Chronic rejection can become a long-term problem. Complex conditions can make rejection difficult to treat.
Acute cellular rejection occurs in 25-50% of all liver transplant recipients within the first year after transplantation with the highest risk period within the first four to six weeks of transplantation. Once the diagnosis is made, treatment is fairly straightforward and generally very effective.
About 2 patients in every 100 undergoing liver resection will die within the peri-operative period as a result of a complication. It is extremely rare to die during liver surgery in the operating room.
The 1-, 5- and 10-year graft survival rates of liver transplant recipients who were younger than 65 years were 82.1%, 67.8% and 52.6%, respectively; for recipients who were 65 years or older they were 77.5%, 59.7% and 41.2%, respectively.
Liver resection may be required for liver cancer or other diseases of the liver. This operation will vary depending on how much of the liver needs to be removed. After surgery, the liver is able to regenerate its own tissue, and you can expect to have a relatively good quality of life following surgery.
Liver transplant can have excellent outcomes. Recipients have been known to live a normal life over 30 years after the operation.
However, Liver Transplant cost in India ranges vary from Rs. 22,50,000 to Rs. 30,75,000 (twenty-two lakh fifty thousand to thirty lakh seventy-five thousand) and depends upon multiple factors and differs from case to case). However, cost may vary depending upon the different hospitals in different cities.
You may be disqualified from having a liver transplant if you have: Current alcohol or drug abuse problems. Uncontrolled infection that will not go away with a transplant. Metastatic cancer or bile duct cancer.
Lung transplant patients have the lowest 5- and 10-year survival rates, according to UNOS. “The lungs are a very difficult organ to transplant because they're exposed to the environment constantly as we breathe,” explained Dr. Steves Ring, Professor of Cardiovascular and Thoracic Surgery. Dr.