Most people with HPV do not experience symptoms. However, some types of HPV cause warts or bumps on the skin. They may occur in or around the genitals, anus, tongue, mouth, or lips. Sometimes, HPV also causes warts on other areas of skin, such as the hands or feet.
Most cases of HPV are asymptomatic, meaning you will not have any noticeable signs or symptoms. For those who do experience symptoms, they may include: Genital warts (a bump or group of bumps in the genital area) Cervical dysplasia (the presence of abnormal precancerous cells on the cervix)
Most people with HPV do not know they have the infection. They never develop symptoms or health problems from it. Some people find out they have HPV when they get genital warts. Women may find out they have HPV when they get an abnormal Pap test result (during cervical cancer screening).
HPV usually doesn't make you feel sick or cause any symptoms. Your immune system can fight off the infection before you ever know you have it, but you could still spread it to others before that happens. If you do get symptoms, the most common signs of HPV are genital warts.
Often, HPV warts will appear three to six months after sexual relations with an infected person; or they may take months to appear; or they may never appear. Likewise, the interval between an infection with HPV and a cervical smear abnormality can vary from months to decades.
Signs of HPV
The most common are small, hard sores called warts, but not everyone who has HPV gets them. They may be raised, flat, or shaped like a cauliflower, and they can be different sizes. They can show up on your genital area or other places, depending on the type of the virus you have.
Patients with HPV-unrelated tumors experienced significantly higher levels of fatigue over the course of the study (p=0.0097, Table 2), especially at pre-IMRT (p=0.001) and three-month post-IMRT (p=0.002), compared to those with HPV-related tumors (Figure 1a).
Most people infected with HPV do not develop any symptoms or health problems from the virus because the body's immune system is able to fight off the infection. “For the overwhelming majority of people, having an HPV infection has no impact on their lives,” Dr. Cullins says.
– there's no evidence that HPV has triggers like herpes or asthma that cause flare ups, but many believe that a weakened immune system can lead to outbreaks being more likely. Genital warts are more likely to flare-up if your immune system is not able to effectively fight the HPV infection causing them to appear.
When the body's immune system can't get rid of an HPV infection with oncogenic HPV types, it can linger over time and turn normal cells into abnormal cells and then cancer. About 10% of women with HPV infection on their cervix will develop long-lasting HPV infections that put them at risk for cervical cancer.
In women, these strains can cause cancers of the cervix, vagina, vulva, and anus, as well as head and neck cancers. Almost all cases of cervical cancers are caused by the HPV virus. In men, high risk strains of HPV can cause penile, anal and head and neck cancers.
Discharge, itching, burning, fissures and dyspareunia were typical symptoms. Discharge was more frequent in women with vaginal localization of the HPV infection, whereas itching and burning were the predominant complaint when the HPV lesions were present on the vulva.
The warts may go away, stay the same, or grow in size or number. A healthcare provider can usually diagnose genital warts by looking at them. Genital warts can come back, even after treatment. The types of HPV that cause warts do not cause cancer.
Around 90% of HPV infections clear within 2 years. For a small number of women and people with a cervix, their immune system will not be able to get rid of HPV. This is called a persistent infection. A persistent HPV infection causes the cells of the cervix to change.
Several factors are important for the regression of HPV manifestation/infection, among which is psychological stress which can prolong the duration and severity of HPV disease. Stress hormones may reactivate latent tumor viruses, stimulate viral oncogene expression, and inhibit antiviral host responses.
Research has found that it can take 10 to 20 years, or even longer, for HPV-infected cervical cells to develop into a cancerous tumor. Among women whose cervical cells are infected with high-risk HPV, several factors increase the chance that the infection will be long lasting and lead to precancerous cervical cells.
Folate (vitamin B9)
According to a 2021 study , folate and vitamin B12 were found to play a critical role in lowering the risk of contracting a strain of HPV (HPV 16) and an associated form of cervical precancer (cervical intraepithelial neoplasia, otherwise known as CIN).
Almost all cervical cancers are thought to be caused by HPV infections. While there are often no signs of early cervical cancer, some signs may include: Increased vaginal discharge, which may be pale, watery, pink, brown, bloody, or foul-smelling.
past infection with HPV was significantly more common in patients with RA than in controls. The results confirm the arthritogenicpotential of HPV and are consistent with the hypothesis that rheumatoid arthritis may develop in a genetically predisposed patient after an arthritogenic insult such as an HPV infection.
A compromised immune response is the prerequisite for disease progression. One unique feature of HPV infection is that it can affect the immune system in such as way that it presents a much more tolerant state, which facilitates persistent hrHPV infection and cervical lesion progression.
A Pap test screens for cancer of the cervix (the passageway between the vagina and the uterus). A Pap test can also be used to screen for non-visible (subclinical) human papilloma virus (HPV) infection. The Pap test is not a specific test for HPV, although sometimes the results suggest that HPV might be present.
Patients with HPV-positive throat cancer have a disease-free survival rate of 85-90 percent over five years. This is in contrast to the traditional patient population of excessive smokers and drinkers with advanced disease who have a five- year survival rate of approximately 25- 40 percent.