Up to now it is very difficult to cure vitiligo, although many therapeutic methods have been reported. We used Metharmon-F™, a sex hormone-thyroid powder mixture for the treatment of vitiligo with high repigmented ratio.
Generalized vitiligo is linked to autoimmune thyroid disease like Hashimoto's disease and Graves' disease [21]. TSH (thyroid-stimulating hormone) or thyrotropin is a dimeric glycoprotein hormone.
Ruxolitinib (Opzelura™) is the only medication approved by the U.S. Food and Drug Administration (FDA) to restore lost skin color in people who have vitiligo.
A 2-year study of 100 patients with vitiligo, who were treated with oral folic acid (5 mg) and VitB12 (1 mg) in combination with sunlight exposure and UVB radiation, showed re-pigmentation in 52 participants with stable and progressive vitiligo.
Pimecrolimus and tacrolimus are unlicensed for treating vitiligo, but they can be used to help restore skin pigment in adults and children with vitiligo. They can cause side effects, such as: a burning or painful sensation when applied to the skin. making skin more sensitive to sunlight.
A topical cream called ruxolitinib is the first therapy approved by the U.S. Federal Drug Administration (FDA) to restore pigment in vitiligo patients.
Vitiligo is generally considered to be an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs. In people with vitiligo the immune system appears to attack the pigment cells (melanocytes) in the skin .
What is Narrowband UVB (NB-UVB)? NB-UVB, now considered the gold standard of treatment for vitiligo, is a more recent vitiligo treatment than PUVA, and uses the portion of the UVB spectrum from 311-313 nm.
There is no cure yet for vitiligo, but there are ways to treat it. Unfortunately, treatments for vitiligo don't always work, and even when they do, vitiligo can come back. Some body areas are very difficult to treat. The good news is there are now promising therapies on the horizon.
FDA approves Ruxolitinib (Opzelura) for Vitiligo Therapy: A breakthrough in the field of dermatology. Received 2022 Aug 18; Accepted 2022 Aug 19.
Cuts, burns, and even the friction that occurs when skin rubs against skin have been found to set off vitiligo flares. This is due to a reaction called the Koebner phenomenon, which also occurs in other skin conditions, such as psoriasis and lichen planus.
Studies suggest that vitamin D3 increases tyrosinase activity and melanogenesis in vitro [12], which may lead to repigmentation in vitiligo skin lesions. Calcipotriol and tacalcitol, which are vitamin D analogs, are also known to induce repigmentation in patients with vitiligo [13,14].
Some food items like juicy fruits rich in vitamin C or ascorbic acid such as oranges and lemon, other fermented food items as curd, alcohol, Fish, red meat are to be avoided as they have harmful effect on vitiligo and can give rise to spreading of patches.
Conclusion: some hormonal indicators have a role in pathogenesis of vitiligo where their disturbance leads to melanocyte destruction and/or depigmentation. Vitiligo is an idiopathic disorder of skin and hair characterized by melanin loss.
Vitiligo is a common pigmentary disorder caused by the destruction of functional melanocytes. Vitamin D is an essential hormone synthesized in the skin and is responsible for skin pigmentation. Low levels of vitamin D have been observed in vitiligo patients and in patients with other autoimmune diseases.
Hormonal connections: Affection of certain hormones such as Thyroid hormones or Melanocyte Stimulating hormone may be responsible for vitiligo. Also, the simultaneous occurrence of vitiligo and other hormonal disorder suggests an underlying genetic factor.
No drug can stop the process of vitiligo — the loss of pigment cells (melanocytes). But some drugs, used alone, in combination or with light therapy, can help restore some color. Drugs that control inflammation. Applying a corticosteroid cream to affected skin might return color.
In conclusion, the findings from this study indicate that vitiligo patients have high levels of perceived stress. In patients predisposed to vitiligo, metabolic and psychological stress might influence the onset and progression of vitiligo.
Zinc plays a key role in the immune system, reproductive health, and sensory functioning, as well as neurobehavioral development. It is also an important coenzyme in the reactions of melanin synthesis. It has been suggested that zinc supplements are a beneficial adjuvant therapy for patients with vitiligo.
There is no cure for vitiligo; however, pharmacological treatment measures (cosmetic camouflage creams, steroids, psoralen and ultraviolet A (PUVA) therapy, narrowband UVB) are available, but they could have certain side effects.
About 10% to 20% of people who have vitiligo fully regain their skin color. This is most common among people who: Receive an early diagnosis before age 20.
Vitiligo is an autoimmune disease of the skin, which means that someone with vitiligo has an immune system that is malfunctioning in a small way. The normal role of the immune system is to protect you from infections and cancer.