Schizophrenia is most closely linked to complex interactions between genetic predispositions, abnormalities in brain chemistry (especially dopamine and glutamate), and environmental factors. No single factor is considered the sole cause.
It isn't known what causes schizophrenia. But researchers believe that a mix of genetics, brain chemistry and environment can play a part. Changes in certain naturally occurring brain chemicals, including neurotransmitters called dopamine and glutamate, may play a part in schizophrenia.
Research suggests a combination of physical, genetic, psychological and environmental factors can make a person more likely to develop the condition. Some people may be prone to schizophrenia, and a stressful or emotional life event might trigger a psychotic episode.
Cluster A and avoidant personality disorders are regarded as risk factors or antecedents for the development of schizophrenia. Some features of borderline personality disorder may resemble schizophrenia.
Here are five potential causes:
Scientists believe that people with schizophrenia have an imbalance of the neurotransmitters (brain chemicals) serotonin, dopamine, and glutamate. These neurotransmitters allow nerve cells in the brain to send messages to each other.
Auditory hallucinations, or “hearing voices,” are the most common in schizophrenia and related psychotic disorders. Disorganized thinking and speech refer to thoughts and speech that are jumbled or do not make sense.
Bipolar disorder.
People with bipolar disorder often have periods of being “up” or “on” when they're extremely energized or happy, then fall into periods of deep depression. Some people with severe bipolar disorder have delusions or hallucinations. That's why they may be misdiagnosed with schizophrenia.
The "25 rule" (or "rule of quarters") in schizophrenia suggests that outcomes fall into four roughly equal groups: 25% recover fully, 25% improve significantly with some ongoing support, 25% improve somewhat but need considerable help, and 25% have a poor outcome with chronic illness or suicide risk, highlighting the varied nature of schizophrenia's long-term course, though some sources use a "rule of thirds" with similar proportions for different outcomes.
In a previous study negative symptoms were significantly predicted by high Neuroticism, and low Extraversion, Openness, and Agreeableness (Ross et al., 2002). Positive symptoms were associated with high Neuroticism and Openness, and low Agreeableness (Ross et al., 2002).
Schizophrenia isn't caused by just one genetic variation, but a complex interplay of genetics and environmental influences. Heredity does play a strong role — your likelihood of developing schizophrenia is more than 6 times higher if you have a close relative, such as a parent or sibling, with the disorder.
Despite relative geographical proximity, the DALY rate of schizophrenia in Indonesia is nearly double that of Australia (the nations with the highest and lowest respective DALY rates).
The symptoms of schizophrenia are usually classified into:
Clozapine is the gold standard for therapy of treatment-resistant schizophrenia despite causing a plethora of side effects. ECT is being used increasingly in schizophrenia as a promising augmentation strategy with clozapine in clozapine-resistant schizophrenia.
Among these, the 5 A's of Schizophrenia serve as essential markers for identifying and assessing the disorder. These include Alogia, Avolition, Anhedonia, Affective Flattening, and Asociality. Each of these symptoms represents a diminished or absent function that is critical for daily living and social interaction.
Although symptoms typically start in late adolescence or early adulthood, schizophrenia is often viewed from a developmental perspective. Cognitive impairment and unusual behaviors sometimes appear in childhood, and persistent presence of multiple symptoms represent a later stage of the disorder.
Speech may be mildly disorganized or completely incoherent and incomprehensible. Disorganized (bizarre) behavior may take the form of childlike silliness, agitation, or inappropriate appearance, hygiene, or conduct.
There's no single test for schizophrenia and the condition is usually diagnosed after assessment by a specialist in mental health. If you're concerned you may be developing symptoms of schizophrenia, see a GP as soon as possible. The earlier schizophrenia is treated, the better.
In most people with schizophrenia, symptoms generally start in the mid- to late 20s, though it can start later, up to the mid-30s. Schizophrenia is considered early onset when it starts before the age of 18. Onset of schizophrenia in children younger than age 13 is extremely rare.
Antipsychotics. Antipsychotics are usually recommended as the initial treatment for the symptoms of an acute schizophrenic episode. They work by blocking the effect of the chemical dopamine, or other chemicals on the brain.
Meta-analyses and mega-analyses of structural MRI and diffusion MRI studies in thousands of people with schizophrenia have shown reduced brain volumes and structural connectivity relative to healthy control participants. Some of these structural differences probably present pre-morbidly.
Types of schizophrenia
One of the early signs of schizophrenia is social withdrawal. Individuals may begin to distance themselves from friends and family, showing a lack of interest in social activities they once enjoyed. They might become reclusive, preferring to spend time alone.
Avoiding drugs and alcohol
Alcohol and drug use can also cause other mental health problems, such as depression and anxiety as well as causing damage to your physical health. Drugs and alcohol can also react badly with antipsychotic medicines.
Onset is most often during late adolescence and the twenties, and onset tends to happen earlier among men than among women. Schizophrenia is frequently associated with significant distress and impairment in personal, family, social, educational, occupational, and other important areas of life.