No single flea/tick treatment is universally "killing dogs," but concerns and adverse events have been linked to specific active ingredients like isoxazolines (Bravecto, NexGard, Simparica) and fipronil/imidacloprid (Frontline, Advantix, Seresto), especially with improper use, counterfeits, or sensitivities, causing neurological issues or poisoning. The FDA and vets emphasize that these products are generally safe when used correctly but highlight potential severe reactions (tremors, seizures) with isoxazolines, urging owner vigilance and vet consultation.
The active ingredients, such as pyrethrins, pyrethroids, and organophosphates, are designed to kill fleas but can be harmful to pets if they are exposed to too much of them.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
NexGard (afoxolaner) is a safe, FDA-approved flea and tick prevention that most dogs can take. It's available as a once-monthly chewable tablet and is prescribed based on your dog's weight. Side effects of NexGard in dogs are rare but can include vomiting and diarrhea. The most serious risk of NexGard is seizures.
BRAVECTO (fluralaner) Chews for Dogs: The most commonly reported adverse reactions include vomiting, lethargy, diarrhea, anorexia and pruritus. In some cases, adverse events have been reported following use in breeding females.
There are several oral prescription flea and tick medications that are safe for dogs. These preventatives come in pill and chew forms. Your vet can help you find the right one for your pup's age. Credelio Quattro is an excellent choice for flea and tick protection.
Both products are safe for dogs when following directions and can be used in breeding, pregnant, or lactating dogs. Frontline Plus is available for both cats and dogs. Bravecto is available as a topical treatment for cats - which provides an added benefit of being able to repel fleas and ticks.
Simparica products are usually well tolerated in animals. There is minimal risk for overdose, side effects, or drug interactions if used as labeled or as directed by your veterinarian. Simparica products are available from your veterinarian or with a prescription from your veterinary pharmacy.
The leading cause of death in dogs, especially older dogs, is cancer (neoplasia), affecting about 1 in 4 dogs, similar to humans, with specific breeds at higher risk. Other significant causes include old age, heart disease, digestive disorders (like bloat), infectious diseases (like Parvo), and trauma, with sterilization influencing risks for cancer and infections.
These products are safe to use in the majority of pets, but there are some pets that cannot tolerate the medication (specific liver disorders, pre-existing seizure disorders).
BREAKING THE FLEA LIFE CYCLE
Veterinary professional organizations recommend using an oral or topical flea product, such as Bravecto® (fluralaner), regularly all year round to break the flea life cycle and keep your pet flea free5.
Fluralaner (Bravecto; Merck Animal Health) and afoxolaner (Nexgard; Merial, Inc) are isoxazoline paraciticides available as chewable tablets and marketed to kill fleas and ticks on dogs. Fluralaner is given once every 3 months and afoxolaner is given once every month.
Yes, you can switch between Bravecto and NexGard. Just don't overlap doses and talk to your vet before making the change - especially if your dog has had side effects.
Cedarwood oil solution (10 drops per 1 ounce of water) can be applied to both pets and the environment once to twice daily. Cedarwood mulch is a helpful deterrent for landscaping. For moderate infestations, Dr. Trish uses Revolution and for severe infestations, she recommends Nexgard.
Poison pills that can harm pets
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
"Silent killer" in dogs usually refers to deadly diseases that progress with few early symptoms, primarily Heartworm, Hemangiosarcoma (a type of cancer), and sometimes Leptospirosis or Canine Parvovirus, all characterized by vague initial signs, rapid progression, and severe organ damage, making prevention and early detection crucial.
The sound your dog made might have been due to an involuntary reflex or a sudden surge of adrenaline or pain at the moment of passing. This can happen quite rapidly and is sometimes associated with underlying conditions like heart issues or a sudden seizure.
Metaldehyde is the most common known cause of dog deaths in cases referred to the Veterinary Poisons Information Service (VPIS). Dogs may initially appear unsteady on their feet and twitchy, but may rapidly deteriorate and suffer continuous convulsions and possibly respiratory failure.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
It's not uncommon for pets to experience mild side effects after taking medication like Simparica Trio. Lethargy can occur, but it's crucial to watch for any severe reactions such as vomiting or seizures. If your dog's lethargy continues or they show signs of distress, contacting your vet is the best course of action.
In these studies, NexGard PLUS chews were found to be well tolerated and safe for use in dogs and puppies at 8 weeks, weighing 4 lbs or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. They are safe for use in all breeds of dogs.
Not all flea treatments are harmful. The Pesticide Action Network warn us about two chemicals which are harmful to human health; fipronil and permethrin. These have both been found to have links to cancer and suspected endocrine disruption which means they can interfere with your hormone system.
Use NexGard PLUS with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information. Following the use of HEARTGARD Plus (ivermectin/pyrantel) in dogs, digestive and neurologic side effects and itching have been reported.
Advantage products are usually well tolerated in animals. There is minimal risk for overdose, side effects, or drug interactions if used as labeled or as directed by your veterinarian. Advantage XD and Advantage II products are available without a prescription.