There are no known interactions between statin medications and multivitamin and mineral supplements.
Vitamin D supplement may have moderate or no effect on the dosage requirement or side effects of pravastatin, rosuvastatin and pitavastatin. Since vitamin D has mild HMG-CoA reductase activity, it will work synergistically with all statins.
A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption. People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.
Vitamin D and cholesterol: What to know. The connection, if any, between vitamin D and cholesterol is unclear. Some research suggests that vitamin D supplements may improve cholesterol levels. However, others indicate that vitamin D has no effect on low-density lipoprotein (LDL) cholesterol.
We know that taking blood pressure tablets in the morning is beneficial in controlling high blood pressure, but more recent findings (enabled by the use of 24-hour blood pressure monitoring) suggest that night-time dosing may have an even better effect.
You can choose to take it at any time, as long as you stick to the same time every day. This prevents your blood levels from becoming too high or too low. Sometimes doctors may recommend taking it in the evening. This is because your body makes most cholesterol at night.
Simvastatin, pravastatin & fluvastatin are statin's that work better if taken in the evening. Studies show that when simvastatin is taken at night, there is a greater reduction in LDL cholesterol than when the statin is taken in the morning.
Cautions and interactions. Statins shouldn't be taken if you have severe liver disease or blood tests suggest that your liver may not be working properly. This is because statins can affect your liver, and this is more likely to cause serious problems if you already have a severely damaged liver.
It is fine to take painkillers such as paracetamol, ibuprofen, co-codamol with simvastatin.
Which cholesterol-lowering drug is the safest? Overall, statins are safe as a class of drugs. Serious adverse events are very rare. Among the individual medications, studies have shown that simvastatin (Zocor®) and pravastatin (Pravachol®) seem to be safer and better tolerated than the other statins.
A systematic review found that short-acting statins worked best when people took them in the evening. The people who took these statins toward the end of the day had lower total cholesterol and LDL cholesterol levels compared with the people who took them in the morning.
If you take them in the morning, they may not be as effective in the evening. So it's recommended to take these statins in the evening: Fluvastatin (IR capsules)
Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes.
If you've made lifestyle changes through diet and exercise that have lowered your cholesterol levels, you may not need to continue taking a statin. These changes can help reduce your risk of heart attack, stroke, or blocked arteries while allowing you to take one less medication.
A Statin Alternative Lowers Heart Attack Risk by 23 Percent, Drug Trial Shows. People who can't or won't take statin medications to reduce LDL cholesterol may want to talk to their doctor about bempedoic acid (Nexletol).
Elevated serum cholesterol is a risk factor in the development of coronary artery disease. Magnesium has been reported to decrease total serum cholesterol, low density lipoprotein, and very low density lipoprotein, and increase high density lipoprotein.
Supplements that should be avoided include red yeast rice, garlic, sustained-release niacin, no flush niacin, and niacinamide. These supplements have no data to support their use in lowering cholesterol levels or have been associated with liver damage.
Low vitamin D levels could result in dyslipidemia, and lipid abnormalities—that is, an increase in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels and a decrease in high-density lipoprotein cholesterol (HDL-C) level—have been identified as important risk factors for ...