Multiple sclerosis (MS) is very similar to the Sjögren's syndrome (SS) by its clinical presentations.
Sjögren's often is undiagnosed or misdiagnosed. The symptoms of Sjögren's may mimic those of menopause, drug side effects, allergies, or medical conditions such as lupus, rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, and multiple sclerosis.
This condition is frequently associated with other autoimmune disorders including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Sjogren syndrome is managed by replacing moisture at affected glandular sites and diminishing the autoimmune response locally as well as systemically.
Sjögren's syndrome is a chronic, autoimmune disease. It can occur alone or with other autoimmune conditions like rheumatoid arthritis (RA) or lupus. Sjögren's syndrome presents with dry eyes and dry mouth. Inflammation of the tear ducts and saliva glands cause dryness and irritation.
The lymphoaggressive nature of the disease appears to lead SS patients from stage I to II and from stage II to III. However, stage III patients made up only 5% of SS patients. Many patients remain stable in stages I or II for as long as 10 or 20 years.
Over time, the immune system for people with Sjogren's syndrome can damage other parts of your body, including joints, nerves, skin, and organs such as kidneys, liver, and lungs. These long-term consequences can be quite debilitating.
Clinical and immunological parameters of Sjögren's syndrome
SS has been reported to be associated with other autoimmune diseases such as SLE, RA, autoimmune thyroid disease (AITD), SSc, and, less frequently, multiple sclerosis (MS) and antiphospholipid syndrome (APS) [25,26].
The main symptom is dry eyes; the patient may feel a burning, stinging or gritty sensation. Other possible symptoms are blurred vision or sensitivity to intense light, specifically fluorescent light.
Sjögren's syndrome can cause nerve damage which regulates the coordination of heartbeat, respiration, and gastric motility. This is called an “autonomic neuropathy.” Examples of symptoms include lightheadedness when standing, decreased or increased sweating, and feeling full despite eating small meals.
Ultrasound imaging and biopsy can help determine if the salivary gland tissues are altered by inflammation. Blood tests can identify antibodies that are typically present in people with Sjögren's syndrome and other autoimmune disorders.
Blood tests
In Sjögren's syndrome, the immune system produces antibodies that attack healthy areas of the body. These can be found during a blood test. But not everyone with Sjögren's syndrome has these antibodies, so you may have the condition even if a blood test does not find them.
Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis.
Hydroxychloroquine; first-line treatment. Methotrexate. Hydroxychloroquine plus methotrexate. Short-term (1 month or less) corticosteroids (15 mg or less a day); long-term corticosteroids (≤15 mg/d for more than 1 month) may be useful, but efforts should be made to find a steroid-sparing agent as soon as possible.
Patients with Sjogren's syndrome (SS) frequently have irritable bowel like symptoms (IBS). Some have celiac sprue.
Share on Pinterest Sjogren's is caused by white blood cells mistakenly attacking moisture-producing glands. The causes of Sjogren's remain largely unknown. Studies have indicated that a viral or bacterial infection may trigger the disease, but that the underlying cause is primarily genetic and environmental.
The disorder can affect the nervous system, muscles, joints, kidneys, lungs, blood vessels, liver, and pancreas. Sjögren's syndrome is a long-lasting disorder that affects females more often than men.
A wide variety of nervous system complications are characteristic features of Sjogren's syndrome, of which peripheral neuropathy — damage of the peripheral nerves — is a major one. Peripheral neuropathy can cause weakness, numbness, and pain, usually in the hands and feet.
Sjogren's Syndrome patients often complain of mental fatigue or “brain fog.” Brain fog impairs focus, causes fuzzy concentration, and contributes to difficulty in problem-solving.
Age: Most people who are diagnosed with Sjögren's syndrome are 40 or older, but it can affect younger individuals, including children. Gender: Women are as much as 10 times more likely to develop Sjögren's syndrome than men. This imbalance may be related to the effect of sex hormones on a woman's immune system.
Researchers have determined the risks as follows: People with two or fewer of these signs and symptoms have a 3.8 percent chance of developing the condition. Those with three to six risk factors have a 39.9 percent chance of developing lymphoma.
Sjögren's syndrome can sometimes lead to complications. For example, your eyesight could be permanently damaged if the reduced tear production isn't treated. Sjögren's syndrome also increases your risk of developing non-Hodgkin lymphoma, which is a cancer of the lymph glands.
Inflammation can cause pneumonia, bronchitis or other problems in your lungs; lead to problems with kidney function; and cause hepatitis or cirrhosis in your liver. Lymph nodes. A small percentage of people with Sjogren's syndrome develop cancer of the lymph nodes (lymphoma).
Research shows people with Sjögren's syndrome are about 5 times more likely to get non-Hodgkin lymphoma than people who do not have the condition. But the chances of getting it are still small. See a GP if you have symptoms of non-Hodgkin lymphoma, such as: painless swollen glands, usually in your neck, armpit or groin.