There are no specific tests for MS . Instead, a diagnosis of multiple sclerosis often relies on ruling out other conditions that might produce similar signs and symptoms, known as a differential diagnosis. Your doctor is likely to start with a thorough medical history and examination.
While there is no definitive blood test for MS, blood tests can rule out other conditions that cause symptoms similar to those of MS, including lupus erythematosis, Sjogren's, vitamin and mineral deficiencies, some infections, and rare hereditary diseases.
Inflammation in a myelinated portion of the nervous system is the mainstay of multiple sclerosis (MS). Elevation of inflammatory markers such as procalcitonin, ESR and hs-CRP is suspected to occur in MS patients.
People should consider the diagnosis of MS if they have one or more of these symptoms: vision loss in one or both eyes. acute paralysis in the legs or along one side of the body. acute numbness and tingling in a limb.
There are also multiple infectious entities that mimic MS including; progressive multi-focal leukoencephalopathy (PML), Toxoplasmosis, Tuberculosis, Herpes Simplex Virus, Cytomegalovirus, Varicella zoster virus, Epstein Barr virus, Cryptococcus and Human immunodeficiency virus.
There is no definite measure or laboratory marker for the diagnosis of MS, yet. Both the clinical features of the disease, and laboratory investigations such as magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) analyses are being used.
Numbness of the face, body, or extremities (arms and legs) is often the first symptom experienced by those eventually diagnosed as having MS.
Tingling sensations and numbness are one of the most common warning signs of MS. Common sites of numbness include the face, arms, legs, and fingers.
While there is no definitive blood test for MS, blood tests can rule out other conditions that cause symptoms similar to those of MS, including Lyme disease, a group of diseases known as collagen-vascular diseases, certain rare hereditary disorders and acquired immune deficiency syndrome (AIDS).
MS is usually diagnosed between the ages of 20 and 50, but it can go undetected for years. In fact, a 2021 study suggested that many people with MS experience disease symptoms several years before being officially diagnosed with the disease.
Multiple sclerosis is a T-cell–mediated autoimmune disease in which inflammation is sustained by autoreactive T cells directed against components of myelin.
CRP is higher during MS relapses and associated with EDSS, predictive for later progression and decreasing during interferon beta 1a therapy (30–32). Therefore, peripheral inflammation is probably linked to general disease activity in MS, too.
The first step in diagnosing MS is taking a thorough medical history. Your doctor will ask you about your symptoms, including when they began and whether you've noticed any patterns or triggers. They may also ask you about: injuries, diseases, or other health conditions with which you've been diagnosed.
Relapsing-Remitting MS (RRMS)
The most common type of MS is called RRMS. It is defined by temporary periods called relapses, flare-ups or exacerbations, when new symptoms appear. Individuals with this MS type experience clearly defined attacks of worsening neurologic condition.
Vision Problems
The first symptom of MS for many people. Optic neuritis, neuromyelitis optica, blurred vision, poor contrast or color vision, and pain on eye movement can be frightening — and should be evaluated promptly.
Multiple sclerosis is caused by your immune system mistakenly attacking the brain and nerves. It's not clear why this happens but it may be a combination of genetic and environmental factors.
Early symptoms can include vision problems, trouble walking, and tingling feelings. MS affects people differently. But common problems are trouble with movement and thinking, and bowel and bladder incontinence.
There are three main investigations that, because of their high specificity and sensitivity, are valuable in the diagnosis of MS: magnetic resonance imaging (MRI), evoked potentials; and cerebrospinal fluid (CSF) examination for the presence of oligoclonal bands (OCBs).
Here's where MS (typically) starts
Optic neuritis, or inflammation of the optic nerve, is usually the most common, Shoemaker says. You may experience eye pain, blurred vision and headache. It often occurs on one side and can eventually lead to partial or total vision loss.