Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis.
Fatigue can lead to depression and diminished quality of life. The Autoimmune Association has heard from people who describe their fatigue in no uncertain terms: It's DEBILITATING! It feels like my body is lugging around a TON OF BRICKS.
ME/CFS shares some features of autoimmune illnesses (diseases in which the immune system attacks healthy tissues in own body, like in rheumatoid arthritis). For example, both ME/CFS and most autoimmune diseases are more common in women and both are characterized by increased inflammation.
If you have fatigue related to lupus, it may feel like you can't possibly get enough rest. Even if you sleep more than you used to, it may feel like it's never enough. You may find that it's harder to do physical and mental work. The effort needed to do everyday tasks may be overwhelming.
This kind of fatigue makes you feel that you are climbing a steep hill when you are really walking on level ground. It may resolve once the underlying organic condition is diagnosed and treated. Thyroid problems and anemia are both common among Sjögren's patients, but many other kinds of fatigue may be superimposed.
Drug Therapies
Antidepressants often prescribed for chronic fatigue include: Tricyclics: amitriptyline (Elavil), desipramine (Norpramin), notriptyline (Pamelor) Selective serotonin reuptake inhibitors (SSRIs): citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft)
The most common lupus symptoms (which are the same for men and women) are: Extreme fatigue (feeling tired all the time) Pain or swelling in the joints. Swelling in the hands, feet, or around the eyes.
It is possible that CFS is underdiagnosed in more than 80% of the people who have it, or is often misdiagnosed as depression. The main problems in diagnosis are: There is no specific test for CFS. Conditions that share the main symptoms of CFS are possibly also being underdiagnosed.
Alan Light's ME/CFS/MS study suggests that people with MS may be more fatigued than people with ME/CFS, but experience much less post-exertional malaise. MS is known to be one of the most fatiguing diseases but ME/CFS is significantly more impairing.
Currently, there is no single test to diagnose ME/CFS. Doctors make a diagnosis by excluding all other illnesses that might be causing symptoms and following accepted diagnostic criteria. The person's results from routine medical tests will often be normal, but additional tests may show abnormalities.
"Fatigue from inflammation in ankylosing spondylitis can feel like you have the flu. You can ache all over," says Rochelle Rosian, MD, the director of regional rheumatology at the Cleveland Clinic in Ohio. “That's because inflammation affects your whole body, not just your joints.”
Common symptoms include fatigue, hair loss, sun sensitivity, painful and swollen joints, unexplained fever, skin rashes, and kidney problems. There is no one test for SLE. Usually, your doctor will ask you about your family and personal medical history and your symptoms. Your doctor will also do some laboratory tests.
It is very rare for someone to have a diagnosis of lupus that has completely negative blood tests- not just one test but a whole panel of them. You can make a diagnosis of lupus on the basis of the skin rash or certain types of kidney disease even if blood tests are negative.
Kidneys About one half of people with lupus experience kidney involvement, and the kidney has become the most extensively studied organ affected by lupus.
Lupus symptoms can also be unclear, can come and go, and can change. On average, it takes nearly six years for people with lupus to be diagnosed, from the time they first notice their lupus symptoms.
The first symptoms of lupus usually occur somewhere between the teen years and the 30s and may be mild, severe, sporadic, or continual. Common general symptoms include fatigue, fever, and hair loss. Lupus can also affect individual organs and body parts, such as the skin, kidneys, and joints.
Most of the time fatigue can be traced to one or more lifestyle issues, such as poor sleep habits or lack of exercise. Fatigue can be caused by a medicine or linked to depression. Sometimes fatigue is a symptom of an illness that needs treatment.
If the fatigue is associated with chest pain, shortness of breath, irregular heart rate, or sense of imminent passing out, these are urgent conditions that warrant immediate medical attention.
In most cases, there's a reason for the fatigue. It might be allergic rhinitis, anemia, depression, fibromyalgia, chronic kidney disease, liver disease, lung disease (COPD), a bacterial or viral infection, or some other health condition.