In some people, high levels of B12 may cause gastrointestinal problems such as bloating and diarrhea. And if you have high blood pressure or poor cardiovascular health, having too much B12 may further complicate these issues. Pregnant and breastfeeding women may also need to be especially mindful of B12 levels.
Excess B12 is either stored in the liver, present in the blood without any adverse effects, or excreted. There are no studies investigating the potential clinical effects of high B12 because, in general, there are no known adverse effects caused by elevated B12.
An abnormally high vitamin B-12 status can be an early sign of liver disease, diabetes, or certain types of leukemia. A doctor may use the results of a vitamin B-12 test to help form their diagnosis.
Other studies focusing on specific cancers have shown a strong association between elevated B12 levels and liver cancers (OR 3.3 [95%CI: 1.1–10.4] for hepatocellular carcinomas and OR 4.7 [95%CI: 1.2–17.9] for other liver cancers) [16], a moderate association with prostate cancer (OR 1.1 [95%CI: 1.0–1.2]) [17], and no ...
Vitamin B12 is a water-soluble vitamin, and the risks of dose-related side effects are low. Your body can usually get rid of excess vitamin B12 through your urine. In rare cases, high doses of vitamin B12 injections have been associated with skin reactions.
Research has suggested that the consumption of alcohol may reduce vitamin B12 levels. An older study indicated that moderate alcohol intake diminished vitamin B12 by 5% among “healthy, well-nourished, postmenopausal women.”
Reduce the amount of animal-derived foods that appear in your diet, as they contain vitamin B12. These include meat, poultry, dairy and shellfish.
Unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body. If a person stops consuming the vitamin, the body's stores of this vitamin usually take about 3 to 5 years to exhaust.
Is taking high doses of B12 helpful or harmful? Since B12 is a water-soluble vitamin, it's generally considered safe, even at high doses. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity.
It's found in large amounts in animal products, fortified foods, and dietary supplements. Some of the richest sources are liver, beef, sardines, clams, and dairy products. Whether you want to increase your vitamin stores or prevent deficiency, eating these foods may considerably improve your overall health.
Stress is known to deplete our levels of B vitamins, especially vitamin B12. Vegetarians, vegans and those on restricted diets can struggle to get enough vitamin B12 to meet their body's needs.
The body will typically excrete excess vitamin B-12 that a person gets from the diet or via supplements. The body does not absorb vitamin B-12 supplements very effectively. This means that even if a person takes very high amounts of vitamin B-12, their body still does not absorb a significant amount.
This new study hints that two nutrients, folate and vitamin B12, might be especially beneficial to help support liver health and potentially reverse nonalcoholic fatty liver disease.
B12 deficiency may cause demyelination of nerves in the peripheral and central nervous system13 and has been associated with peripheral neuropathy, loss of sensation in peripheral nerves, and weakness in lower extremities in older adults1, 14–16.
Our study is in comply with studies indicating that vitamin B12 can be used as tumor marker as in our study indicates that vitamin B12 is significantly high for the patients with HCC compared to control group and patients with cirrhosis.
Significantly Elevated Vitamin B12 Levels in Autoimmune Lymphoproliferative Syndrome (ALPS), a Rare Lymphoproliferative Disorder with Apoptosis Defect | Blood | American Society of Hematology.
Reportedly, patients with diabetes have higher serum vitamin B12 levels than those with normal glycemic control, and fructosamine levels are significantly correlated with serum vitamin B12 levels in patients with DM,8 which suggests that serum vitamin B12 levels may be associated with glycemic control in T2DM.
High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. All conditions may show elevated concentrations of B12 transport proteins.
Patients with neurological symptoms, serum B12 level lower than 200 pg/mL, and with normal folic acid levels were included in the study.
Elevated cobalamin levels often accompany diseases such as leukemia, myeloproliferative disorders, hypereosinophilic syndrome, and metastatic cancer—especially when involving the liver.
Reduce the amount of animal-derived foods that appear in your diet, as they contain vitamin B12. These include meat, poultry, dairy and shellfish.
Symptoms of neuropathy usually stop when the supplements are discontinued. High-dose vitamin B supplements should be avoided, because they can lead to nerve damage.
Unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body. If a person stops consuming the vitamin, the body's stores of this vitamin usually take about 3 to 5 years to exhaust.
In rare cases, people who take high doses of vitamin B for a long period of time may experience extreme numbness or a tingling sensation. In some patients, tingling sensation is experienced mostly in the right side of the body. This symptom is one of the early warning indicators of Vitamin B12 overdose.