constipation • nausea • vomiting • stomach pain • dizziness • drowsiness • skin rashes • sweating. These are the more common side effects of Paracetamol/Codeine GH 500/30. They are usually mild.
Paracetamol/Codeine GH 500/30 may cause dizziness, light-headedness, drowsiness and problems with vision in some people, especially after the first dose. Children should not ride bikes if affected and should be supervised to avoid potential harm.
APX-Paracetamol/Codeine should only be used when your doctor decides that other treatment options are not able to effectively manage your pain or you cannot tolerate them. APX-Paracetamol/Codeine poses risks of abuse, misuse and addiction which can lead to overdose and death.
Paracetamol plus codeine preparations produce a significant increase in analgesia compared with paracetamol alone. Thus, for occasional pain relief this combination therapy may be appropriate, though repeated use increases the occurrence of side-effects.
If you are unsure, please check the information leaflet inside the package, or ask your pharmacist. Codeine may make you feel light-headed, dizzy or drowsy. Make sure you are at home when you take the tablets for the first time, so that you can lie down if you need to. Codeine may also make you feel sick.
Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine".
The most powerful pain relievers are opioids. They are very effective, but they can sometimes have serious side effects. There is also a risk of addiction. Because of the risks, you must use them only under a doctor's supervision.
The addition of codeine provided effective pain relief to about 10% more participants than the same dose of paracetamol alone.
Acetaminophen is generally a safe option to try first for many types of pain, including chronic pain. Ask your health care provider for guidance about other medications to avoid while taking acetaminophen. Acetaminophen is not as effective as NSAIDs for the treatment of knee and hip pain related to osteoarthritis.
Ibuprofen (Advil, Motrin) is a nonsteroidal anti-inflammatory drug (NSAID) that treats pain, fever, and swelling. Many people consider this to be one of the best pain relief medications. In fact, out of 892 reviewers, nearly 9 out of 10 said the drug was worth taking.
Codeine is a painkiller that is part of a group of medicines called opiates. It's used to treat pain, for example, after an operation or an injury. It's also used for ongoing pain when painkillers such as paracetamol, ibuprofen and aspirin have not worked. Codeine is also used to treat diarrhoea.
Codeine is metabolised in the liver to the active compounds morphine and morphine-6-glucuronide.
In placebo controlled studies of paracetamol 1000 mg plus codeine 60 mg 65/114 patients given paracetamol plus codeine had at least 50% pain relief compared with 9/83 for placebo (Table 1). For a single dose of paracetamol/codeine the proportion of patients with at least 50% pain relief was 57% (48% to 66%).
(Do not take Panadeine Forte within 4 hours of taking Panadol). It is important to realise that there are many other types of preparations that may also contain Paracetamol such as cold and flu tablets and these should therefore not be taken in combination with the Panadol.
You can take one or two tablets every four hours, but do not take more than eight tablets in 24 hours. Codeine should only be taken as a 'top up' or 'rescue' painkiller if paracetamol is not sufficient to control your pain.
It is important that you take Paracetamol + Codeine exactly as advised by your doctor. The usual dose for adults and children over 12 years is 1 to 2 tablets every 4 – 6 hours as required. Do not take more than 8 tablets in 24 hours.
You may need to take paracetamol for longer if you have a long-term health problem that causes pain. It's safe to take paracetamol regularly for many years, as long as you do not take more than the recommended dose.
Can I Take Painkillers like Paracetamol with Food or Milk? Painkillers like paracetamol can be taken with our without food. In the case of paracetamol, no adverse food interactions have been documented other than with alcohol or large amounts of caffeine. Paracetamol can be taken with food or on an empty stomach.
Addiction can occur in patients appropriately prescribed Paracetamol + Codeine at recommended doses. The risk of addiction is increased in patients with a personal or family history of substance abuse (including alcohol and prescription and illicit drugs) or mental illness.
Another study also found higher doses was associated with heart attack and stroke, and two others found associations with high blood pressure. One study reported gastrointestinal effects and found overall (36%) increased risk of gastrointestinal bleeds.
Two of the eight studies found that long-term paracetamol users have an increased risk of mortality, up to 63%. One study reported that the risk of gastro-intestinal bleeding and other intestinal side-effects was as high as 36%.
Liver damage results not from paracetamol itself, but from one of its metabolites, N-acetyl-p-benzoquinone imine (NAPQI). NAPQI decreases the liver's glutathione and directly damages cells in the liver. Diagnosis is based on the blood level of paracetamol at specific times after the medication was taken.