Selective estrogen receptor modulators (SERMs) bind to estrogen receptors, preventing estrogen from binding. Examples of SERMs approved by the FDA for treatment of breast cancer are tamoxifen (Nolvadex) and toremifene (Fareston).
Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.
Anastrozole is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen the body makes.
The FDA has approved elacestrant (Orserdu) for the treatment of postmenopausal women or adult men with estrogen receptor–positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least 1 line of endocrine therapy.
DIM (Diindolylmethane/3,3′-Diindolylmethane) is among the most effective estrogen blockers found in nature. It occurs naturally in cruciferous plants such as broccoli, cauliflower, Brussels sprouts and kale.
Natural estrogen blockers:
Some examples of natural estrogen blockers include wild nettle root, maca, chrysin, and grape seed extract. These substances contain compounds that act as natural estrogen blockers and may be used to regulate the production of the hormone.
If your estrogen levels are too high or too low, then magnesium can help bring them back to stable levels, which will positively impact testosterone and progesterone.
Genes associated with follicle growth were not significantly altered by vitamin D3. However, it increases expression of genes involved in the estrogen-biosynthesis. Further, estrogen concentrations in porcine granulosa cell-cultured media increased in response to vitamin D3.
Estrogen blockers can help you regain hormonal balance and to get back to feeling like yourself. However, when it comes to using estrogen blockers, it is important that you only use professionally-prescribed estrogen blockers from real medical experts, not unregulated, over-the-counter products.
All three aromatase inhibitors work the same way and reduce the production of estrogen in the body. How long you continue aromatase inhibitors depends on your specific situation. Current research suggests at least five years of hormone therapy. Some people may benefit from 7 to 10 years of treatment.
Estrogen blockers may stop some cancer cells from growing and are used to prevent and treat breast cancer. They are also being studied in the treatment of other types of cancer. An estrogen blocker is a type of hormone antagonist. Also called antiestrogen.
However, hormone-reducing therapies may cause weight gain in certain subsets of women because they counteract the effects of estrogen, which helps suppress the activity of an enzyme called LPL that pulls fat into cells.
Side Effects
Estrogen-blocking medications have been prescribed for off-label use in those with low testosterone for some time and are often well-tolerated.
Is tamoxifen chemotherapy? No, tamoxifen is a type of hormonal therapy. It belongs to a class of drugs called selective estrogen receptor modulators (SERMs). Sometimes, healthcare providers refer to tamoxifen as “chemoprevention.” But usually, chemoprevention drugs aren't the same as chemotherapy drugs.
Estrogen imbalance: Vitamin D deficiency may lead to lowered estrogen levels, which can cause depression, hot flashes, mood swings and more.
Zinc can rebalance these hormone levels through its antiandrogenic activity which will raise estrogen and progesterone back to baseline.
The best dose of magnesium. A therapeutic dose of magnesium is at least 300 mg which usually equates to three capsules.
This long-term hormone therapy poses a high risk of interactions with dietary supplements. Taking estrogens at the same time as selective estrogen receptor modulators (SERMs), biologically-active compounds of glycine soja, Ginkgo biloba or Pimpinella anisum, may distort the final effect of the hormone agent.
Large amounts of turmeric might interfere with the effects of estrogen. Taking turmeric along with estrogen might decrease the effects of estrogens. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Carrots actually contain unique undigestible fibres to help detox excess estrogen from the body. Raw carrots have been found to help by preventing the reabsorption of estrogen from the intestine, meaning the liver can more effectively regulate metabolism.