The most serious prednisone side effects usually include allergic reactions, infections, gastrointestinal issues and elevated blood sugar. These may occur when people take larger doses or take the medication for long-term treatment.
How long to take it for. This depends on your health problem or condition. You may only need a short course of prednisolone for up to 1 week. You may need to take it for longer, even for many years or the rest of your life.
Other potential side effects—like vision problems and osteoporosis —may be permanent.
Side effects include: Associated with long-term therapy: Bone loss, cataracts, indigestion, muscle weakness, back pain, bruising, oral candidiasis.
A gradual reduction in prednisone dosage gives your adrenal glands time to resume their usual function. The amount of time it takes to taper off prednisone depends on the disease being treated, the dose and duration of use, and other medical considerations. A full recovery can take a week to several months.
However, prolonged use can cause immunosuppression, muscle wasting, bone changes, fluid shifts, and personality changes. For these reasons, prednisone is usually only prescribed short-term.
There is no set limit on how long you can safely take prednisone. It depends on the dose of prednisone and the condition being treated. It may be prescribed short term or long term. The dosage will be adjusted or stopped based on your response or lack of response to the medication.
People taking prednisone can also experience higher blood sugar, which is a special concern for those with diabetes. Because prednisone suppresses the body's immune system, it can also increase the risk of infection.
When a person stops taking prednisone or other steroids abruptly, they may notice symptoms similar to adrenal insufficiency. These include lethargy, low appetite, weight loss, and a general feeling of being unwell. Prednisone is a corticosteroid that doctors prescribe to treat swelling and inflammation.
“Some say it's okay for an RA patient to take 5 mg of daily for years if need be, while others think prednisone is dangerous and want their patients off it completely,” Dr. Tiliakos says. “I'm of the school of thought that it's acceptable to take 5 mg for long periods of time, though it depends on the patient.”
The fear of using corticosteroids is so common that it has its own name: corticophobia. For topical steroids, this fear stems from well-known and severe adverse effects like Cushing syndrome and permanent skin atrophy.
There is no “safe” dose of prednisone. Prednisone over time increases the risk of cardiovascular disease, osteoporosis and infection.
Prednisone side effects are common and can include insomnia, abnormal hair growth, fatigue, thinning of the skin, constipation, and more. 1 While some are manageable, others can be intolerable or even permanent.
If symptoms such as abdominal pain, fever or unusual digestive problems (diarrhea, constipation) occur during corticosteroid therapy, notify your physician.
When taken for extended periods, prednisone interferes with the body's natural production of cortisol. As a result, it is not recommended to stop prednisone abruptly. Doing so can cause body aches, fatigue, fever, and other uncomfortable withdrawal symptoms.
If you've been treated with a high dose of prednisone, or taken it for more than a few weeks, you will need to slowly stop your medicine, usually over a period of days, weeks or months to help prevent withdrawal side effects.
When you taper off prednisone, your adrenal glands have time to catch up and make normal levels of cortisol. This could take weeks or even months, depending on how long you took the medication or how high your dose was.
Prednisone has many side effects. You're more likely to experience these side effects with higher doses and longer courses of treatment. Common short-term side effects include changes in appetite, mood, energy, and sleep. Long-term prednisone treatment can lead to weight gain, osteoporosis, and cataracts.
You can prevent or reverse weight gain from prednisone through lifestyle changes. This includes eating a healthy diet, exercising, and avoiding longer courses of prednisone.
Official answer. Prednisone does not usually cause sleepiness but may make you feel dizzy, irritable with mood swings, or cause you to have trouble sleeping (insomnia). If your dose is stopped too quickly or if you take prednisone for a long period of time you may feel severely fatigued.
For example, a 1–2 week course is often prescribed to ease a severe attack of asthma or gout. This is usually taken without any problems. Side effects are more likely to occur if you take a long course of steroids (more than 2–3 months), or if you take short courses often.
According to the Centers for Disease Control and Prevention, oral and intravenous corticosteroids reduce the activity of the immune system, and people who take them may be at an increased risk for severe illness from the virus that causes COVID-19.
Short-term treatment (7–14 days) with oral prednisone is used for many acute inflammatory and allergic conditions.
Still, dexamethasone is more potent (stronger) than prednisone. If you're in a situation where you need a more potent steroid, dexamethasone will likely be the preferred option between the two. It also works longer in your body than prednisone does.