Yes, new research shows promising blood tests using metabolic "fingerprints" (like Raman spectroscopy) to diagnose fibromyalgia by identifying chemical patterns in blood, potentially replacing the current diagnosis of exclusion, though these are still in validation, not routine clinical use, with existing options like the FM/a test having limitations.
Lab Tests for Fibromyalgia
Treatment options have historically been limited, and many patients report inadequate relief. On August 15, 2025, the U.S. Food & Drug Administration (FDA) approved a new treatment: Tonmya (cyclobenzaprine HCl sublingual tablets), marking the first new FDA-approved drug for fibromyalgia in more than 15 years.
Easy bruising could also result from nutritional deficiencies often associated with fibromyalgia. "Vitamin deficiencies, like vitamin C, can also increase blood vessel friability, making the vessels more likely to collapse under pressure," adds Pellegrino.
More than two-thirds of those with fibromyalgia also have stomach pain, bloating, gas, and nausea on a regular basis. Constipation or diarrhea can also occur regularly.
dizziness and clumsiness. feeling too hot or too cold – this is because you're not able to regulate your body temperature properly. an overwhelming urge to move your legs (restless legs syndrome) tingling, numbness, prickling or burning sensations in your hands and feet (pins and needles, also known as paraesthesia)
TNX-102 SL (Tonmya; Tonix Pharmaceuticals), cyclobenzaprine HCl sublingual tablets, has been approved by the FDA to treat fibromyalgia in adult patients, making it the first new treatment approved for the musculoskeletal and chronic pain disorder in over 15 years and the fourth treatment approved overall.
Joint swelling, damage and stiffness. Changes in skin color that range from white and mottled to blue or red. Muscle spasms, tremors, weakness and atrophy. Decreased ability to move the affected body part.
On the front of the neck above the collarbone. Just to the right and left of the breastbone (sternum) about 2 in. (5 cm) below the collarbone. On each forearm just below and to the outside of the crease of the elbow.
We showed that 46.8% and 87.2% of the 47 FM patients had tinnitus and headache, respectively, suggesting a high incidence of these symptoms in FM. Koca et al. [16] found that FM patients had more otologic symptoms, including tinnitus and high level of oxidative stress.
Toothaches in those with fibromyalgia aren't always due to typical dental issues such as cavities or gum disease. Instead, fibromyalgia can cause orofacial pain that is unrelated to these common dental problems1.
What treatments can help?
There's no specific fibromyalgia test. But your GP may do some blood tests to rule out other conditions with similar symptoms to fibromyalgia. Sometimes, your GP may refer you to a specialist for further tests or treatment.
Top Vitamins for Fibromyalgia Relief: A Guide to Managing...
Fibromyalgia and the microbiome
A 2025 study showed that faecal microbiota transplantation from fibromyalgia patients into germ-free mice induces pain and numerous molecular phenotypes that parallel known changes in fibromyalgia patients, including immune activation and metabolomic profile alterations6.
There are no specific tests that can confirm a diagnosis of fibromyalgia . But you may have lab tests to rule out other diseases.
Fibromyalgia is a condition that causes pain in muscles and soft tissues all over the body. It is an ongoing (chronic) condition. It can affect your neck, shoulders, back, chest, hips, buttocks, arms, and legs. The pain may be worse in the morning and evening.
The best places to live with fibromyalgia
Cervical pain, and even facial pain, especially in terms of masticatory fatigue, are extremely common in FS. Comorbidities are also extremely common, even in the field of orofacial pain, as up to 80% of patients with FM also suffer from headaches or temporomandibular disorders [6].
The symbol most associated with Fibromyalgia is the butterfly. This was adopted as although a butterfly is light and weightless it could still cause pain if it landed on someone with the condition due to their heightened sensitivity to pain and pressure.
Some describe it as the creepy-crawly feeling of invisible insects marching over their skin. People who live with fibromyalgia often experience paresthesia – any abnormal sensation of the skin that doesn't have an apparent physical cause.
Cyclobenzaprine and tizanidine are muscle relaxants that may be used to help manage symptoms of fibromyalgia. These medications can reduce muscle tension and improve sleep, addressing common challenges faced by those with the condition.
Milnacipran (brand name: Joncia®) belongs to a class of medicines called serotonin and noradrenaline reuptake inhibitors (SNRI). Other similar drugs from this group are used to treat depression and anxiety, but in Australia milnacipran is approved specifically to treat fibromyalgia.
There are no gold-standard treatments for fibromyalgia. Treatment is focused on symptom management. A multidisciplinary approach and individualized treatment plan that incorporates a combination of interventions can help improve outcomes.