Right-sided colorectal cancer (CRC) has worse survival than does left-sided CRC. The objective of this study was to further assess the impact of right-side location on survival and the role of the extent of lymphadenectomy.
Since left-sided tumors have polypoid morphology, it is easier to detect them with colonoscopy in the early stages of carcinogenesis. Right-sided CRC have flat morphology that is difficult to detect [7, 8]. Right-sided CRC patients tend to have advanced and bigger tumors, which are often poorly differentiated.
The location in the colon where cancer develops is one of the factors that's considered when developing your customized treatment plan.
This analysis provides evidence that the prognosis of localized left-sided colon cancer is better compared to right-sided colon cancer. Also, the patients with right colon cancer have more advanced stage, mucinous tumor and are older.
After propensity score matching, the results from risk-adjusted Cox regression analysis were confirmed. Stratified by American Joint Committee on Cancer stage, patients with right-sided stage II colon cancer had a statistically significant superior relative survival compared with patents with left-sided colon cancer.
Background. Right-sided colorectal cancer (CRC) has worse survival than does left-sided CRC. The objective of this study was to further assess the impact of right-side location on survival and the role of the extent of lymphadenectomy.
According to a 2018 study , if right-sided colon cancer is in stage 1 or 2, the outlook is better than early-stage cancers on the left side. But if colon cancer on the right side is in stage 3 or 4, the outlook becomes worse than that of the left side in these stages.
Almost all colon cancers start in the lining of the colon and rectum. When doctors talk about colorectal cancer, this is usually what they are talking about. There is no single cause of colon cancer. Nearly all colon cancers begin as noncancerous (benign) polyps, which slowly develop into cancer.
Nearly all cases of colorectal cancer develop from polyps. They start in the inner lining of the colon and most often affect the left side of the colon and rectum. Detection and removal of polyps through colonoscopy reduces the risk of colorectal cancer.
Depending on their size and location in the colon, serrated polyps may become cancerous. Small, serrated polyps in the lower colon, also known as hyperplastic polyps, are rarely malignant. Larger serrated polyps, which are typically flat (sessile), difficult to detect and located in the upper colon, are precancerous.
The 5-year overall survival rate for patients with right-sided colon cancer was 65.5 % (95 % CI: 65.0 to 66.0 %) compared with 63.0 % (95 % CI: 62.5 to 63.6 %) for patients with left-sided colon cancer.
Colon cancer most often spreads to the liver, but it can also spread to other places like the lungs, brain, peritoneum (the lining of the abdominal cavity), or to distant lymph nodes. In most cases surgery is unlikely to cure these cancers.
It usually begins as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Over time some of these polyps can become colon cancers.
Introduction. Right-side fixation of sigmoid colon is a rare anatomical condition where the sigmoid colon is fixed on the right posterior abdominal wall. It is often associated with dolichosigma and with various forms of intestinal malrotation [1].
The prognostic impact of tumor size was strongly associated with survival in stage III disease. Compared to patients with tumors <2cm; those with 2-5cm (HR 1.33; 1.19-1.49; p<0.001), 5-10cm (HR 1.51 (1.34-1.70; p<0.001) and >10cm (HR 1.95 (1.65-2.31; p<0.001) had worse survival independent of other variables.
If the cancer is diagnosed at a localized stage, the survival rate is 91%. If the cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the 5-year survival rate is 72%. If colon cancer has spread to distant parts of the body, the 5-year survival rate is 14%.
Most polyps are benign (not cancerous). Your doctor can tell if a colon polyp is cancerous during a colonoscopy by collecting tissue to biopsy. The results of the biopsy are typically sent to your doctor within a week. Only 5% to 10% of all polyps become cancerous.
Most polyps grow slowly and take from between 10 and 15 years to become cancerous.
If a polyp has cancerous cells, they will also biopsy nearby lymph nodes to determine if the cancer has spread or metastasized to other areas of the body. In this case radiation, chemotherapy or other therapies may be recommended. Colonoscopy screenings can be life saving!
Stages 0–4
A higher stage indicates a larger tumor or that the cancer has spread into the surrounding tissue or lymph nodes. Stages 1–3 indicate that the cancer has not yet spread to other parts of the body. Stage 4 cancer has spread to other parts of the body.
In most cases, colon and rectal cancers grow slowly over many years. Most of those cancers start as a growth called a polyp.
Right-sided colon cancer significantly outnumbered left-sided colon cancer, with 44,544 (57.1%) of subjects having right-sided and 33,434 (42.9%) left-sided colon cancer (P<. 001) (Table 1).
How fast does colon cancer spread? Colorectal cancer tends to spread to the liver and lungs 2 years after initial cancer surgery.