Therefore, these findings indicate that although taking SSRIs alone could significantly reduce the depression score, adding magnesium supplements to this treatment significantly reduced and improved the depression score.
4 The study also found that the participants who were taking an antidepressant experienced stronger benefits when taking magnesium, which suggests that it might be useful when used in conjunction with antidepressant medications.
And taking drugs such as marijuana, cocaine, amphetamines, heroin, or recreational ketamine while on an antidepressant may make your depressive symptoms worse, according to the NHS.
"Serotonin and melatonin are crucial in determining your mood. Magnesium works as an important co-factor required for conversion of tryptophan (from proteins we get from food) to serotonin and melatonin, both of which help in falling asleep."
Magnesium and drugs use the same transport and metabolism pathways in the body for their intestinal absorption, metabolism, and elimination. This means that when one or more drug is taken, there is always a potential risk of interaction with the magnesium status.
Potassium, Calcium, Zinc, and Magnesium
Large doses of these mineral supplements can compete for absorption if taken at the same time and will not be as effective. If you take more than one mineral supplement, take them separately and at least two hours apart.
Antibiotics: Taking magnesium supplements may reduce the absorption of quinolone antibiotics, tetracycline antibiotics, and nitrofurantoin (Macrodandin). Magnesium should be taken 1 hour before or 2 hours after taking these medications. Quinolone and tetracycline antibiotics include: Ciprofloxacin (Cipro)
Can I take Lexapro with magnesium supplements, such as magnesium glycinate? It should be safe to take Lexapro with magnesium supplements, including magnesium glycinate. There isn't a known interaction between Lexapro and these supplements.
Medical research has linked magnesium to reduced anxiety. Magnesium helps you to relax by stimulating the production of melatonin and serotonin which boost your mood and help you sleep. Magnesium also reduces the production of cytokines and cortisol, which lead to increased inflammation and stress.
Interactions between your drugs
No interactions were found between calcium carbonate / magnesium chloride and Zoloft. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
New stressors. A new stressful situation at home or work can result in a mood response for which the antidepressant can't compensate. Other medications. Interactions between antidepressants and medications for other health conditions can affect how well an antidepressant works.
Specifically, weight gain seems to be a common long-term risk, especially the medications that affect serotonin levels. This could be because serotonin is associated with an increase in appetite. There is also a risk of higher blood sugar levels and diabetes with taking antidepressants long-term.
Magnesium may also reduce the absorption of medications such as blood thinners, anti-diabetes drugs, diuretics, and drugs used to treat the brittle bone disease osteoporosis, Cooperman says. “Check with your doctor if you're considering using magnesium,” he says.
Do not use escitalopram with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. John's wort, amphetamines, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®).
Early signs of excessive magnesium intake can include low blood pressure, facial flushing, depression, urine retention, and fatigue. Eventually, if untreated, these symptoms can worsen and include muscle weakness, difficulty breathing, irregular heartbeat, and even, in very rare cases, cardiac arrest.
The benefits of magnesium supplementation in healthy individuals aren't clear, but Dr. Nassar says that taking a magnesium supplement every day likely isn't unsafe for most people. Just be sure you're not taking too much magnesium. The maximum dietary allowance for most adults is around 400 mg or less.