Glucosamine should be used with caution in patients with renal impairment; side effects and renal function should be monitored. It is advisable to avoid glucosamine for patients with severe renal impairment and those on dialysis until more data are available.
In some statistics, people who take glucosamine for more than 2 years experience acute interstitial nephritis as a side effect. There are also patients with nonspecific signs of renal failure and high levels of renal and hepatic toxicity, who have had a long history of glucosamine-related products.
You may need to avoid some vitamins and minerals if you have kidney disease. Some of these include vitamins A, E and K. These vitamins are more likely to build up in your body and can cause harm if you have too much. Over time, they can cause dizziness, nausea, and even death.
Glucosamine should be used with caution in patients with renal impairment, with monitoring of side effects and renal function (17). It is advisable to avoid use in patients with severe renal impairment and those on dialysis (16). Glucosamine is used for the relief of pain and symptoms associated with osteoarthritis.
Vitamins that are typically recommended for CKD patients:
B1, B2, B6, B 12, folic acid, niacin, pantothenic acid, and biotin, as well as some vitamin C, are essential vitamins for people with CKD. Vitamin C may be suggested in low doses as large doses can cause a buildup of oxalate.
Glucosamine sulfate may contain high amounts of sodium or potassium. People on a restricted diet or who take potassium-sparing diuretics should carefully check the label before taking glucosamine supplements.
1. Vitamin D. The kidneys are responsible for converting vitamin D into active metabolites and are essential for absorbing calcium and phosphorus. Those suffering from chronic kidney disease may have low vitamin D levels primarily because damaged kidneys have difficulty converting vitamin D into its active form.
People with CKD have greater requirements for some water soluble vitamins. Special renal vitamins are usually prescribed to provide extra water soluble vitamins needed. Renal vitamins contain vitamins B1, B2, B6, B12, folic acid, niacin, pantothenic acid, biotin and a small dose of vitamin C.
Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin.
Because glucosamine products might be derived from the shells of shellfish, there is concern that the supplement could cause an allergic reaction in people with shellfish allergies. Glucosamine might worsen asthma. There's some concern that glucosamine might raise eye pressure.
Glucosamine can cause some mild side effects including bloating, nausea, diarrhea, and constipation. When applied to the skin: N-acetyl glucosamine is possibly safe when used for up to 10 weeks.
It is OK to take glucosamine every day, but check with your healthcare provider. For example, with osteoarthritis, the following doses have been studied: By mouth: 1,500 milligrams (mg) per day, taken either at once, in two doses of 750 mg, or in three doses of 500 mg.
The lowdown. While it is generally a safe spice, consuming too much turmeric could lead to certain side effects, including the formation of kidney stones. If you are predisposed to kidney stones, you should avoid taking curcumin-based supplements before speaking to your doctor.
Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.
The calcium antagonistic effect of magnesium is also important for reducing the risk of kidney stones, and silent kidney stones significantly increase the risk of kidney failure. As low magnesium intake will reduce the urinary magnesium concentration, the beneficial effect of magnesium on stone formation is hampered.
Your kidneys could be damaged if you take large amounts of over-the-counter medications, such as aspirin, naproxen and ibuprofen. None of these medicines should be taken daily or regularly without first talking to your healthcare provider.
Glucosamine and chondroitin are considered safe, with no serious side effects reported in studies. However, these supplements can interact with blood thinners like warfarin (Coumadin).
THE ROLE OF GLUCOSAMINE SULFATE
Glucosamine supposedly plays a part in the repair and maintenance of joint cartilage, stimulating cartilage cells to produce GAGs and proteoglycans.
Glucosamine and chondroitin are non-vitamin, non-mineral supplements which have anti-inflammatory properties. These supplements are typically used for joint pain and osteoarthritis, and are commonly taken as either glucosamine alone or as glucosamine plus chondroitin.