Although clotrimazole was first used against fungal infections, a body of research was later developed indicating that this drug has anticancer properties as well. The mechanism of action is based on the inhibition of mitochondrial-bound glycolytic enzymes and calmodulin, which starves cancer cells of energy.
When clotrimazole is applied locally and topically, toxic effects such as pelvic cramps, hives, skin rash, occasional headache, itching, and irritation of the vulva and vagina may be observed. Stop the medication if there are any adverse effects.
Clinicians have observed that prolonged use of voriconazole, a frequently prescribed antifungal medication, is linked to the development of cutaneous squamous cell carcinoma (cSCC), the second most common form of cancer.
Pharmacokinetics. As previously mentioned, clotrimazole has very poor oral bioavailability. Less than 3% is absorbed from mucosal surfaces and less than 0.5% is absorbed through the skin. Most of the absorbed drug is metabolized on first pass through the liver.
Despite decades of widespread use, clotrimazole has not been linked to instances of clinically apparent hepatotoxicity. Likelihood score: E (unlikely cause of clinically apparent liver injury).
Do not use clotrimazole cream, spray or solution for more than 4 weeks, unless a doctor tells you to. Fungal infections can become resistant to clotrimazole and it can stop working properly. The most common side effect of clotrimazole is skin irritation in the area you've treated.
If you use too much clotrimazole cream, spray or solution or use it more often than you need to, it may make your skin irritated or red. If this happens, use less the next time.
Keep this medicine away from the eyes. When clotrimazole is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such as kitchen plastic wrap) should not be applied over the medicine. To do so may cause irritation of the skin.
Since fungus infections may be very slow to clear up, you may have to continue using this medicine every day for several weeks or more. If you stop using this medicine too soon, your symptoms may return.
Since fungus infections may be very slow to clear up, you may have to continue using this medicine every day for several weeks or more. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses .
The antifungals fluconazole and itraconazole are considered relatively safe; they have been associated with only minor changes in liver function tests that usually do not require interruption of treatment. Fluconazole is widely used in the treatment of various fungal infections.
Topical antifungals (creams, liquids, sprays, and shampoos) are generally well tolerated and do not cause severe side effects. Some people may experience mild redness, burning, irritation, or itching at the application site.
Candida albicans is an opportunistic pathogenic fungus, which tends to infect the host with defective immune function including cancer patients. A growing number of studies have shown that C. albicans infection increases the host susceptibility to cancer such as oral, gastric, and colorectal cancer.
Clotrimazole is an antifungal medicine. Side-effects are unlikely but may include mild skin irritation or itching. If your symptoms do not improve within seven days, speak with your doctor. Do not use more than two courses of clotrimazole within six months without speaking with a doctor for further advice.
CLOTRIMAZOLE; BETAMETHASONE (kloe TRIM a zole; bay ta METH a sone) is a corticosteroid and antifungal cream. It treats ringworm and infections like jock itch and athlete's foot.
This product contains cetostearyl alcohol which may cause local skin reactions (e.g. contact dermatitis). The medicine also contains 20mg benzyl alcohol in each gram of cream. Benzyl alcohol may cause allergic reactions and mild local irritation.
If you do, rinse out with plenty of cool tap water. Use this medicine at regular intervals. Do not use more often than directed. Finish the full course prescribed by your doctor or health care professional even if you think you are better.
It comes as a single application that you use once. Clotrimazole external cream is used 2 or 3 times a day for at least 2 weeks.
It is active against many medically important fungi and yeasts and is available as a cream or as pessaries; an oral preparation is under trial. Care should be taken to distinguish clotrimazole from co-trimoxazole (Septrin - Burroughs Wellcome; Bactrim - Roche), a totally unrelated drug.
High doses or long-term use of betamethasone and clotrimazole topical can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.
If you use too much clotrimazole, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. If clotrimazole is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur.
This medicine is for use in the vagina. It may also be applied to the external areas of skin around the vagina to decrease itching and discomfort.
Clotrimazole for thrush (Canesten) Brand name: Canesten.
Seemingly every medical condition has myths surrounding it. Cancer is no exception. One such myth is that the fungus Candida causes cancer or that cancer cells are actually a form of fungus. Research has revealed neither to be true.