Realistic weight loss with Saxenda (liraglutide) averages around 5% to 10% of body weight over a year, with many losing about 10-23 pounds, but results vary, and significant loss (over 20%) is possible for some, especially when combined with diet and exercise. Studies show most users lose some weight (around 85%), with about a third losing over 10% of their initial weight, though it's crucial to remember this is an average, and some may lose less, notes Drugs.com and Second Nature.
Okay, now let's take a look at some Saxenda weight loss results from scientific research. After one month on the medicine, clinical trials suggest that most people will lose about 2-3% of their starting weight.
56% achieved significant weight loss at year 1, and. Approximately half of these patients maintained weight loss at 3 years when taking Saxenda® added to a reduced-calorie meal plan and increased physical activity, compared with people not on the drug.
Tricyclic antidepressants (TCAs) such as amitriptyline are older antidepressants often associated with weight gain and increased appetite. Whilst there is no pharmacological interaction with Saxenda, the opposing effects on weight may reduce the overall effectiveness of weight management efforts.
Furthermore, in a phase IV clinical study of FDA data on the drug Saxenda, migraines were a side effect [47].
Does Saxenda affect your face? Facial changes are not commonly reported side effects of Saxenda. The medication primarily targets weight management through its effects on appetite regulation. If you notice any unusual changes in your face or facial features while on Saxenda, consult with your healthcare provider.
Drink enough water to avoid dehydration
When starting Saxenda, it can cause nausea (feeling sick), vomiting (being sick) and diarrhoea (runny poo) that can last for a few days. This increases your risk of dehydration, which can cause serious kidney problems. Be sure to drink plenty of water or non-sugary beverages.
Saxenda interactions with vitamins and minerals
Chromium may decrease blood sugar levels. Saxenda may also cause low blood sugar as a side effect. * Taking chromium with Saxenda can increase your risk of having low blood sugar. Due to this, your doctor may recommend avoiding chromium products during Saxenda treatment.
Bupropion (brand name Wellbutrin) stands out as an antidepressant that can promote weight loss. Unlike many other antidepressants, bupropion doesn't typically cause weight gain.
It's best to take it before you go to bed because it can make you sleepy. If you still feel drowsy in the morning you could try taking it earlier in the evening. Amitriptyline does not usually upset your stomach.
Saxenda (liraglutide) works by mimicking GLP-1, a naturally occurring hormone that regulates appetite and blood sugar. Whilst it does not directly alter sex hormones like oestrogen or testosterone, it does influence metabolic hormones and can indirectly affect hormonal balance through weight loss.
The 3-3-3 rule for weight loss is a simple, habit-based method focusing on three key areas: 3 balanced meals a day, 3 bottles (or ~1.5L) of water by 3 PM, and 3 hours of physical activity per week, aiming for consistency over complex diets. It simplifies fat loss by establishing rhythm through consistent eating, adequate hydration to support metabolism, and regular movement, promoting sustainable health without intense calorie counting or restrictive rules, says Five Diamond Fitness and Wellness, Joon Medical Wellness & Aesthetics, and EatingWell.
You can use Saxenda® at any time of day, with or without food and drinks. It is preferable to use Saxenda® at about the same time each day, at a time that is most convenient for you. Only continue using Saxenda® if you have lost at least 5% of your initial body weight after 12 weeks on the 3.0 mg/day dose.
Saxenda (liraglutide) is a once-daily weight-loss injection. Saxenda may start working in as little as 2 weeks. Full effects are typically seen about 6 months after starting it. Saxenda works by mimicking a natural gut hormone that helps regulate appetite.
Two of the most discussed weight loss injections currently on the market are semaglutide and tirzepatide, which are both FDA-approved for weight management.
Sustainable weight loss requires addressing psychological factors like stress, emotional eating, and negative body image. Behavioural changes and mindset shifts are crucial for long-term success.
Wellbutrin® (bupropion) is often associated with weight loss. It may even be combined with another drug called naltrexone — together, they're sold under the brand name Contrave® — to enhance weight loss among people living with obesity. Desyrel® (trazodone) may lead to some weight gain.
There are many medications that may cause hair loss. Common examples include chemotherapy, antidepressants, and anti-seizure medications. Birth control pills, azole antifungals, and some arthritis and antithyroid medications may also lead to hair loss. Oral retinoids, tamoxifen, and blood thinners can cause hair loss.
Foods to avoid while on Saxenda® to reduce side effects
Take these tips from the Calibrate medical team for a spin: Avoid fried, greasy, or fatty foods and foods high in sugar: These tend to be the toughest for your body to digest and the most likely to cause nausea while taking a GLP-1 medication.
Saxenda is given as an injection under the skin (subcutaneous injection). The best places to inject are the front of your waist (abdomen), the front of your thighs or your upper arm. Change the place where you inject each day to reduce the risk of developing lumps. Do not inject into a vein or muscle.
Prioritize protein on GLP-1
The goal here should be about 1.2 grams of protein per day per kilogram of body weight (or 0.55 grams of protein per pound of body weight), Christen says.
Drinking alcohol can make some Saxenda side effects worse, especially if you have dizziness or nausea. It can also increase the risk of getting low blood sugar. It is best to limit or avoid alcohol consumption whilst taking Saxenda, as alcohol also contains a lot of calories and can impact weight loss.
Some causes of unintentional weight loss include: mental health conditions, such as depression, anxiety, eating disorders and obsessive compulsive disorder (OCD) problems with digestion, such as coeliac disease or inflammatory bowel disease (IBD) hormone conditions, such as an overactive thyroid or type 1 diabetes.
For weight loss, the best alcohol choices are low-calorie, low-sugar options like spirits (vodka, gin, whiskey) mixed with soda water/diet mixers, light beer, hard seltzers, or dry wines/champagne, focusing on minimal sugar and avoiding creamy, sugary cocktails which add significant calories. Pure spirits (vodka, tequila, gin, whiskey) have about 100 calories per 1.5 oz serving with zero carbs, making them great choices, especially when drunk neat or on the rocks.