Reported improvement (e.g. reduction in painful symptoms) varies from three weeks to as much as eight weeks. Some studies have shown continued improvement of symptoms after oral intake was stopped. Generally, if there is no pain reduction after two months, there is little chance of improvement.
Glucosamine sulfate might provide some pain relief for people with osteoarthritis. The supplement appears to be safe and might be a helpful option for people who can't take nonsteroidal anti-inflammatory drugs (NSAIDs). While study results are mixed, glucosamine sulfate might be worth a try.
Most studies show that chondroitin needs to be taken for 2 to 4 months before subjects experience benefits, although you may notice some improvement sooner. Glucosamine and chondroitin can be used along with NSAIDs to treat OA.
Study results on this question have been mixed, with some suggesting possible benefit and some showing no benefit on cartilage protection. Glucosamine is one of the substances in your body that is used to build cartilage.
You can take glucosamine at any time during this that feels most convenient for you. There is some opinion that drinking in the morning is best. There are some people who like to drink them with meals. Others prefer to drink them on an empty stomach with a glass or two of water.
While collagen provides structural support to the body's connective tissues, glucosamine plays a crucial role in the formation of healthy cartilage. Both collagen and glucosamine supplements have been shown to support joint health and alleviate the symptoms of osteoarthritis.
To begin with, try things like swimming, cycling, and walking briskly. For strength in the knee joints, try wall squats, calf raises, hamstring curls, and leg raises.
Glucosamine sulphate and glucosamine hydrochloride are nutritional supplements. Animal studies have found that glucosamine can both delay the breakdown of and repair damaged cartilage. The results for the use of glucosamine for osteoarthritis are mixed and the size of the effect is modest.
Your doctor may recommend the RICE regimen—rest, ice, compression, and elevation—to treat a knee cartilage injury. Resting your knee can help reduce the symptoms associated with the injury.
Reported improvement (e.g. reduction in painful symptoms) varies from three weeks to as much as eight weeks. Some studies have shown continued improvement of symptoms after oral intake was stopped. Generally, if there is no pain reduction after two months, there is little chance of improvement.
Glucosamine hydrochloride is possibly safe for most adults when used for up to 2 years. N-acetyl glucosamine is also possibly safe when used for up to 6 months. Glucosamine can cause some mild side effects including bloating, nausea, diarrhea, and constipation.
Glucosamine and chondroitin have anti-inflammatory properties. “They also have some cartilage-protecting effects through a variety of different mechanisms,” says Chris D'Adamo, PhD, director of Research & Education at the University of Maryland School of Medicine Center for Integrative Medicine.
Over-the-counter medications — such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) — may help ease knee pain. Some people find relief by rubbing the affected knee with creams containing a numbing agent, such as lidocaine, or capsaicin, the substance that makes chili peppers hot.
Chondroitin is believed to enhance the shock-absorbing properties of collagen and block enzymes that break down cartilage. Like glucosamine, this supplement is thought to help cartilage retain water, keep joints lubricated, and possibly reverse cartilage loss.
Dosage and Preparation
It is OK to take glucosamine every day, but check with your healthcare provider. For example, with osteoarthritis, the following doses have been studied: By mouth: 1,500 milligrams (mg) per day, taken either at once, in two doses of 750 mg, or in three doses of 500 mg.
Vitamins D and K are both important for bone strength, and vitamin K is involved in cartilage structure. Supplementing these two nutrients may be helpful if you're deficient in them. When you take supplements as directed and under your doctor's supervision, they're generally safe.
Cartilage Regeneration Options
MACI is a surgical procedure that uses cartilage-forming cells from your body to restore damaged cartilage in the knees. It involves a biopsy to harvest chondrocytes (cartilage-forming cells), which are allowed to multiply in a lab, and surgery to implant them into the damaged area.
Dietary supplements: Dietary supplements such as glucosamine and chondroitin are the non-surgical treatment options for cartilage restoration. Chrondroitin sulphate and glucosamine are naturally occurring substances in the body that prevent degradation of cartilage and promote formation of new cartilage.
The procedure—called autologous chondrocyte implantation (ACI)—takes healthy cartilage cells from the damaged knee, cultures them in a lab for four to six weeks, and then injects the new cells into the damaged joint for regeneration with the surrounding cartilage.
Knee cartilage injury recovery time
In severe cases it could take up to 18 months. As athletes return to activity, they must carefully monitor knee pain and limit activities that increase the likelihood of another injury before fully healing.
knee pain or tenderness. stiffness or swelling around your knee – the swelling may not start for a few hours or days. difficulty bending, straightening or moving your knee. your knee giving way when you try to stand.
There are in fact, no known side effects or drug interactions recorded between any medications with collagen. Glucosamine is a known medication used to treat and prevent joint pain, inflammation and has also been known to relieve osteoporosis and arthritic symptoms for those who suffer with them.
Collagen has been extensively studied as a potential OA treatment. Research quality varies, but most findings are positive. One small observational study found that a hydrolyzed collagen called Promerim significantly reduced pain and stiffness in people with knee OA.