Early warning signs of sepsis include fever/chills, feeling very unwell, rapid heart rate, fast breathing, confusion, extreme pain, and skin changes (pale, mottled, sweaty); these symptoms, often stemming from an infection, signal a medical emergency, especially when severe or worsening, requiring immediate hospital care. In children, signs can also be less specific, like floppiness, poor feeding, or a non-fading rash.
Symptoms
Stage 1: Sepsis
A high fever above 101℉ (38℃) or low temperature below 96.8℉ (36℃) A heart rate above 90 beats per minute. A bacterial infection, fungal infection, or viral infection confirmed through positive blood culture results. Rapid breathing rate higher than 20 breaths per minute.
To check yourself for sepsis, watch for a combination of symptoms like fast breathing, rapid heart rate, confusion or drowsiness, fever or low temperature, shivering, extreme pain/discomfort, clammy skin, or a rash that doesn't fade, and decreased urination, especially if you have an infection. Sepsis is a medical emergency, so if you suspect it, seek immediate medical help by calling emergency services or going to the hospital.
The development of sepsis can vary from person to person and depends on several factors. It can manifest rapidly within hours or take a few days to fully develop. Regardless of the speed of progression, early detection and prompt medical attention are vital for the management and treatment of sepsis.
The research discussed here includes the following subset of the core measure sepsis bundle, the components of which must be completed within 3 hours of presentation time: measure serum lactate level, obtain blood cultures before administration of antibiotics, and administer broad spectrum antibiotics.
You, your child or someone you look after: feels very unwell or like there's something seriously wrong. has not had a pee all day (for adults and older children) or in the last 12 hours (for babies and young children) keeps vomiting and cannot keep any food or milk down (for babies and young children)
About sepsis
At a glance. Sepsis is a fast-moving, life-threatening emergency caused by an extreme immune response to infection. Use TIME: Temperature, Infection, Mental decline, Extremely ill — to recognize sepsis symptoms early. Prevent sepsis by treating infections early, practicing hygiene and staying current on vaccinations.
The six main symptoms of sepsis are: Shortness of breath. Fever, chills, shivering, or feeling very cold. High heart rate or low blood pressure.
These infections are most often linked to sepsis:
Many sepsis survivors have said that when they were ill, it was the worst they ever felt. It was the worst sore throat, worst abdominal pain, or they felt that they were going to die. Children developing sepsis may exhibit different symptoms, as seen below.
The evidence behind the “golden hour” protocol
The main finding was that patients who received antibiotics within the first hour of sepsis recognition had a 79.9% chance of survival. It was also found that with every additional hour, the chance of survival decreased by 7.6%.
A consensus conference in 1991 defined “sepsis” as the combination of an infection with two or more features of what was called the “systemic inflammatory response syndrome” (SIRS): altered body temperature, elevated pulse rate, elevated respiratory rate and abnormal white blood cell count6.
In the early stages, sepsis (blood poisoning) can look like the flu or another common illness. You might feel feverish, get chills, or notice your heart racing a bit faster than usual. These symptoms might seem standard, but when your immune system starts to misfire, even these subtle symptoms can be a red flag.
Bacterial infections are one of the most common causes of sepsis. Fungal, parasitic and viral infections are also potential sepsis causes. You can get sepsis when an infection triggers a chain reaction throughout your body causing organ dysfunction.
Sepsis symptoms can start very subtly, or they can come on suddenly. The symptoms may mimic flu or another virus. It's important to look for the warning signs of sepsis. Spotting these symptoms early could prevent the body from entering septic shock and could save a life.
These conditions include anaphylaxis, gastrointestinal emergency, pulmonary disease, metabolic abnormality, toxin ingestion/withdrawal, vasculitis, and spinal injury.
Kidney failure can also be a result of sepsis. Sepsis can overwhelm the body. This can cause vital organs to shut down. This usually starts with the kidneys.
The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis: Titrate oxygen to a saturation target of 94% Take blood cultures and consider source control. Administer empiric intravenous antibiotics.
Here's a list of seven symptoms that call for attention.
Because sepsis can happen quickly, it is important to be alert for early signs. The most common signs include the following: Source of infection (cough, sore throat, abdominal pain, pain with urination) and fevers. High heart rate.
Feeling or acting confused or not wanting to do things you usually do. Being sleepier than normal or being hard to wake up. Feeling very poorly or like something is really wrong with your body. Not peeing all day (or in 12 hours for babies and young children).
Sepsis is diagnosed through a combination of rapid clinical assessment (fever, fast heart/breathing rate, confusion, low blood pressure) and tests like blood cultures, CBC, lactate, CRP, and urine/fluid analysis, often using tools like qSOFA, to find the infection source and check organ function, as there's no single test for it. Doctors look for signs of organ dysfunction alongside suspected infection, ordering imaging (X-rays, CT scans) to pinpoint the cause, with immediate antibiotic treatment crucial even before definitive results arrive.
If you have signs of sepsis, your GP will send you to hospital. Treatment for sepsis depends on: where the initial infection is and what caused it.