When the body senses danger from a virus or infection, the immune system kicks into gear and attacks it. This is called an immune response. Sometimes, healthy cells and tissues are caught up in this response, resulting in autoimmune disease.
The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.
For many autoimmune diseases, symptoms come and go, or can be mild sometimes and severe at others. When symptoms go away for a while, it's called remission. Flares are the sudden and severe onset of symptoms.
According to a 2014 study, women get autoimmune diseases at a rate of about 2 to 1 compared to men — 6.4% of women versus 2.7% of men. The disease often starts during childbearing age (ages 15 to 44). Some autoimmune diseases are more common in certain ethnic groups.
Many types of autoimmune diseases cause redness, swelling, heat, and pain, which are the signs and symptoms of inflammation. But other illnesses can cause the same symptoms. The symptoms of autoimmune diseases can come and go. During a flare-up, your symptoms may get severe for a while.
In fact, if an autoimmune disorder is left untreated, it can lead to more serious complications and even death. The person will also run a higher risk of infections.
Use nutrients such as fish oil, vitamin C, vitamin D, and probiotics to help calm your immune response naturally. Exercise regularly — it's a natural anti-inflammatory. Practice deep relaxation like yoga, deep breathing, biofeedback, or massage, because stress worsens the immune response.
Antinuclear antibodies are markers for a number of autoimmune diseases, the most notable of which is systemic lupus erythematosus (Ferrell and Tan, 1985). Antibodies to specific nuclear constituents are high specific for certain collagen vascular diseases.
An autoimmune disease is the result of the immune system accidentally attacking your body instead of protecting it. It's unclear why your immune system does this. There are over 100 known autoimmune diseases. Common ones include lupus, rheumatoid arthritis, Crohn's disease and ulcerative colitis.
Physical and psychological stress has been implicated in the development of autoimmune disease, since numerous animal and human studies demonstrated the effect of sundry stressors on immune function.
Autoimmune disorders in general cannot be cured, but the condition can be controlled in many cases. Historically, treatments include: anti-inflammatory drugs – to reduce inflammation and pain. corticosteroids – to reduce inflammation.
Flares last anywhere from weeks to months, unless there is a change in care to address them. Those of us involved in functional medicine understand that nothing simply “just happens” in the body. There's always a reason why. If you have an AI condition, it's extremely important to know what can trigger a flare.
Vitamin D has a key role in modulating immune function with important consequences on health maintenance and disease occurrence, particularly autoimmune disorders. Low serum levels of 25(OH)D have been associated with increased risk of autoimmune disease onset and/or high disease activity.
The antinuclear antibody (ANA) immunofluorescence assay (IFA) is a first-line screening test for patients with a suspected autoimmune disease. This test is the gold standard because of its high sensitivity compared to other assays.
Abnormal levels of red blood cells, hemoglobin, or hematocrit may be a sign of anemia, heart disease, or too little iron in your body. Low white cell count may be a sign of an autoimmune disorder, bone marrow disorder, or cancer. High white cell count may be a sign of an infection or a reaction to medicine.
One blood test for autoimmune disease is C-reactive protein (CRP). Another test is ESR (erythrocyte sedimentation rate) - this is done to assess an inflammation that is not from an infection or due to other reasons. One of the most common blood tests for detecting autoimmune disorders is ANA (antinuclear antibodies).
Choose Calming Foods
Fruits and vegetables (aim for a broad rainbow of colors to get the most antioxidant variety), fish and fish oil, olive oil, ground flaxseeds, and spices like ginger, rosemary, basil and turmeric can all have a quieting effect on an overactive immune system.
An overactive immune system
If you are born with certain genes, your immune system may react to substances in the environment that are normally harmless. These substances are called allergens. Having an allergic reaction is the most common example of an overactive immune system.
On a basic level, autoimmune disease occurs because the body's natural defenses — the immune system — attack the body's own healthy tissue. Researchers have several ideas about why this happens. When the body senses danger from a virus or infection, the immune system kicks into gear and attacks it.
Life and death with an autoimmune disease
These conditions include everything from rheumatoid arthritis, which causes pain and swelling in the joints and raises the risk for life-threatening cardiovascular disease, to lupus, a chronic disease that can cause inflammation in any part of the body.
Autoimmune cytopenias may be temporary and require little to no treatment. If treated, the goal of therapy is to remove the autoantibodies and let the body replenish the blood cells.