Zinc has shown to play an important role in
The zinc chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) inhibits the release of histamine, the production of cytokines, and the secretion of lipid mediators in mast cells, and zinc supplementation rescues these inhibitory effects.
Vitamin C
Vitamin C boosts the immune system. It also acts as a natural antihistamine. According to a 2018 study on vitamin C in the treatment of allergies, oxidative stress plays a key role in allergic diseases. As vitamin C is a powerful antioxidant and anti-inflammatory, it may act as a treatment for allergies.
Zn is essential for FcεRI-mediated cytokine production in mast cell and transcription of IL-6 and TNF-α mRNA4. Zn is also known to function as an antioxidant and stabilize cell membranes3.
There is no cure for the condition. You will need to avoid triggers and use medications. If you have anaphylactic reactions, your doctor might also give you an auto-injector epinephrine pen to use in emergencies.
Vitamin D contributes to mast cell stabilization.
What is the most powerful natural antihistamine? Researchers haven't yet established any natural product as the “best” or “most powerful.” Natural antihistamines with the most research backing their use include stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics.
Vitamin C is a natural antihistamine, which means it can lower histamine levels and mitigate allergic reactions and symptoms. Consume plenty of Vitamin C rich foods, like tropical fruits, citrus fruits, broccoli and cauliflower, and berries.
Magnesium is also needed to make the enzyme, DAO, which mops up histamine when it's been released, if you can't make DAO, histamine levels in the blood increase 16.
No interactions were found between Benadryl and zinc sulfate. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health.
We know that the right amount of zinc is critical to intestinal health. If we consume too much or too little zinc, the intestinal barrier falls apart. An over- or underabundance of zinc can cause shifts in the gut microbiome, and cause diarrhea and inflammation.
“Antihistamines” control allergy symptoms by blocking histamine activity. But our body can also produce enzymes such as histamine-N-methyltransferase and diamine oxidase (DAO) capable of inactivating histamine.
If you're experiencing a histamine reaction, try chewing on fresh ginger or pouring boiling hot water over sliced ginger to make fresh ginger tea. In general, you can also drink ginger tea before bed to act as a natural antihistamine and prevent histamine reactions.
Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract.
Claritin and Zyrtec are popular over-the-counter antihistamines. Doctors consider them safe and effective treatments for minor allergies. Both are second-generation antihistamines. These cause less drowsiness than first-generation antihistamines.
In this study, we hypothesized that magnesium, as a known calcium channel blocker, can stabilize the mast cell membrane and reduce mast cell degranulation, which could be one of the mechanisms of its effect on neuroinflammation and its analgesic effect.
Severe deficiency can lead to irreversible brain and nerve damage. However, excess vitamin B12 in the body can cause histamine intolerance symptoms. Studies suggest that vitamin B12 can trigger histamine release in the body.
Another significant link between B6 and histamine intolerance, is B6's role in supporting DAO function to break down histamine. When vitamin B6 is too low, DAO cannot be produced effectively, as B6 plays an important role in the process of DAO formation (3,4,5).