Leptin is thought to be a lipostatic signal that contributes to body weight regulation. Zinc might play an important role in appetite regulation and its administration stimulates leptin production.
In conclusion, the present study provides the first evidence that low and high doses of supplemented Zn attenuate obesity-related central leptin resistance and cognitive decline. Additionally, female obese rats were more responsive to Zn treatment than male obese rats.
Vitamin A was positively associated with leptin concentrations (p < 0.05). Vitamin E concentration was positively associated with abdominal fat, BMI, waist circumference and waist-to-height ratio (p < 0.05).
It was concluded in the concerned study that there was a positive correlation between zinc and leptin and that this effect of zinc on leptin might be mediated by elevated IL-2 and TNF-α levels.
Weight Loss: The Bottom Line
Getting enough zinc in your diet may have a beneficial effect on weight loss if you're overweight or obese. Having said that, zinc does not work that simply. The majority of your weight loss results would stem from making changes to your diet and lifestyle.
The reductions of body weight, body mass index, waist circumference, and hip circumference were significantly higher in the zinc group compared to the placebo group (P = 0.032, 0.025, 0.003, and 0.0001, respectively).
Your thyroid gland needs zinc to produce thyroid hormone, which helps maintain your metabolism and energy. There's even evidence that zinc can help control your appetite. Men should aim for 11 milligrams a day, women at least 8 mg.
Exercise Regularly
Exercise increases leptin levels by increasing sympathetic nerve activity and improving insulin sensitivity. It also leads to changes in adipocytes, the cells that store fat. Adipocytes release more leptin when they are exposed to catecholamines, which are increased during exercise.
Leptin resistance can lead to overeating and excess fat storage. Other health problems can mess with your leptin signaling too. For example, chronic inflammation and high levels of triglycerides (a kind of fat found in your blood) can make it harder for leptin to cross the blood-brain barrier.
The current study has established that vitamin D administration in ESRD patients leads to a rise in adiponectin level and reduction of leptin level.
Leptin secretion Insulin stimulates leptin secretion through a posttranscriptional mechanism that is mainly mediated by the PI3K-PKBmTOR pathway, or other unknown pathways. It has been suggested that the chronic effect of insulin is mediated by glucose metabolism.
Zinc for hormonal balance
Zinc is an adaptogen for several key hormones, helping to rebalance inadequate or excess cortisol, estrogen and progesterone in women. Zinc also reduces inflammation, providing support for healthy hormone production.
For example, women with polycystic ovarian syndrome (PCOS) may require zinc to reduce their testosterone levels, while women with low estrogen may need zinc to help raise their levels.
Zinc can rebalance these hormone levels through its antiandrogenic activity which will raise estrogen and progesterone back to baseline.
The herbs Cinnamomum cassia (Chinese cinnamon) and Gymnema sylvestre may regulate appetite by influencing leptin, glucose, and insulin levels.
It can be concluded that omega-3 decreases leptin level and weight when BMI is within the normal range but in obese patients it may only reduce weight without affecting leptin (and therefore affects the linear relationship between leptin and weight).
Leptin resistance occurs when your brain stops recognizing signals from the satiety hormone, leptin. Instead of feeling full, you feel constantly hungry. Fasting helps reduce the inflammation that causes leptin resistance and resets leptin receptors, encouraging weight loss. Decrease hunger pangs.
Unfortunately, there's not much you can do to raise your leptin levels to decrease hunger and appetite, since your leptin levels are directly related to how much adipose tissue your body has.
Your body doesn't need a large amount of zinc. The recommended daily allowance for adults is 8 - 11 mg. It's common to have slightly low levels of zinc, but taking a multivitamin, plus eating a healthy diet, should give you all the zinc you need.
Do not take zinc supplements if you take amiloride. Blood pressure medications, ACE Inhibitors -- A class of medications called ACE inhibitors, used to treat high blood pressure, may decrease the levels of zinc in your blood. ACE inhibitors include: Captopril (Capoten)
Zinc supports your immune system and muscles. Magnesium plays a role in metabolism and muscle health and helps manage sleep. B6 may boost energy. ZMA makers claim that increasing these three nutrients in your system can build muscle strength and stamina, speed muscle recovery, and improve the quality of your sleep.