Stress activates an immune response that causes the release of hormones epinephrine and cortisol. 1 These hormones exacerbate inflammation and can worsen symptoms of ankylosing spondylitis.
Lack of Exercise Worsens Stiffness
“A sedentary lifestyle will worsen the stiffness and decreased mobility and flexibility that accompany ankylosing spondylitis,” says Waseem Mir, MD, the founder of New York Integrative Rheumatology and a rheumatologist at Lenox Hill Hospital in New York City.
Whether it's through physical therapy or on your own, dedicating time to stretching is key. “We recommend making sure that you maintain your flexibility,” says Dr. Elghawy. “And so doing with physical therapy or flexibility exercises on your own for your low back can provide a lot of relief.”
Uncovering the crosstalk between ER-stress and HLA-B27 triggered autoimmune response and HLA-B27 misfolding; and also the intersections of ER-stress and/or HLA-B27 triggered autoimmune response with other cellular pathways will eventuate with important insights of cellular homeostasis.
“I've encountered patients in my practice who had a major stressful life event — say a major conflict at work or the death of a family member or spouse — and these stressful events can lead to the worsening of their condition and higher levels of inflammation,” Dr. Davis says.
Over time this can damage the spine and lead to the growth of new bone. In some cases this can cause parts of the spine to join up (fuse) and lose flexibility (ankylosis). It's not known exactly what causes AS, but in many cases there seems to be a link with a particular gene variant known as HLA-B27.
There's no cure for ankylosing spondylitis (AS), but treatment is available to help relieve the symptoms. Treatment can also help delay or prevent the process of the spine joining up (fusing) and stiffening. These treatments can also help if you have non-radiographic axial spondyloarthritis.
To treat an AS flare-up, a person can try medication, gentle exercise, and heat or cold therapy. They can also use a transcutaneous electrical nerve stimulation (TENS) machine. A person living with AS may experience frequent flare-ups throughout their life.
Even if ankylosing spondylitis isn't causing you much physical pain, it still may be affecting your emotional health. On any given day you might feel anger, frustration, or even grief. Or maybe multiple feelings at the same time. “People are a beehive of emotions,” says Kenneth J.
The most common symptoms are intermittent flare-ups of spinal pain and stiffness. However, the disease can also affect other joints, as well as the eyes and the intestines. In advanced AS, abnormal bone growth or calcification of the ligaments of the vertebral bodies of the spine may cause the joints to fuse.
Inflammation Uncontrolled systemic (body-wide) inflammation is the factor that best predicts fatigue in AS. Cell messengers called cytokines that are part of the inflammatory process may cause the sensation of fatigue, and inflammation can also cause anemia (inadequate red blood cells), which also causes fatigue.
Ankylosing spondylitis (AS) is a chronic, inflammatory disease of the axial spine. Chronic back pain and progressive spinal stiffness are the most common features of this disease.
Ankylosing spondylitis (AS) (ank-ee-lo-zing spon-dee-li-tus) is a type of arthritis that mainly affects the back, by causing inflammation in the spine. This can make your back, rib cage and neck stiff and painful.
Ankylosing spondylitis is a form of reactive arthritis following Klebsiella infection, usually occurring in an HLA-B27-positive individual.
Some people who have early AS go on to have more severe disease. The bones of the spine can fuse together, a process called “ankylosis.” Doctors call this advanced phase “bamboo spine.” You can feel a lot of pain in your back, stiffness, and soreness, which could limit your flexibility and movements.
"B27 disease" is a new autoimmune disease that afflicts millions of people throughout the world. "B27 disease" occurs in individuals who have ankylosing spondylitis (AS) or preankylosing spondylitis and/or uveitis and are also positive for HLA-B27.
Some people with AS are able to remain fully independent or minimally disabled in the long term. However, some people eventually become severely disabled as a result of the bones in their spine fusing in a fixed position and damage to other joints, such as the hips or knees.
U.S. FDA Approves Pfizer's XELJANZ® (tofacitinib) for the Treatment of Active Ankylosing Spondylitis.
Ankylosing spondylitis is relatively rare, affecting about 1 in 1,000 people. It is believed that people with the gene called HLA-B27 are at the greatest increased risk for developing ankylosing spondylitis, not everyone with the gene develops the condition. Ankylosing spondylitis is more common in men.
While people with ankylosing spondylitis taking biologic medications might be at an increased risk of infections, there is no evidence at this time that suggests that patients with ankylosing spondylitis are at an increased risk of acquiring COVID-19 or having more severe symptoms if they do get sick.