Schizophrenia has been described as the “worst disease” to afflict mankind. It causes psychosis, which is an abnormal state of mind marked by hyperarousal, overactivation of brain circuits, and emotional distress. An untreated episode of psychosis can result in structural brain damage due to neurotoxicity.
Schizophrenia is associated with changes in the structure and functioning of a number of key brain systems, including prefrontal and medial temporal lobe regions involved in working memory and declarative memory, respectively.
So although schizophrenia has no cure and sometimes may get worse over time, the right medications, combined with therapy, can help control the symptoms.
Schizophrenia treatment includes medication, therapy, social and family support, and the use of social services. Treatment must be ongoing, as this is a chronic illness without a cure. When schizophrenia is treated and managed over the long-term, most people can live normal, productive, and fulfilling lives.
Most people with schizophrenia are not violent. Overall, people with schizophrenia are more likely than those without the illness to be harmed by others. For people with schizophrenia, the risk of self-harm and of violence to others is greatest when the illness is untreated.
Brain changes can happen in people whose psychosis goes untreated. “The more relapses and episodes a person has, the more we see that it can permanently change their brain function and structure,” says Tso.
Potential long-term effects of schizophrenia
Destroyed relationships with family and friends. Social isolation. Addiction. Significant health problems due to poor self-care and an inability to follow medical advice.
People with schizophrenia generally live about 15 to 20 years less than those without the condition. Schizophrenia is a complex disease. There are many ways it can result in serious complications.
Paranoid schizophrenia
It may develop later in life than other forms. Symptoms include hallucinations and/or delusions, but your speech and emotions may not be affected.
Left untreated, schizophrenia can result in severe problems that affect every area of life. Complications that schizophrenia may cause or be associated with include: Suicide, suicide attempts and thoughts of suicide. Anxiety disorders and obsessive-compulsive disorder (OCD)
Brain scans and tests can also be used in the diagnostic process of schizophrenia, all of which are safe and noninvasive.
In fact, many medical experts today believe there is potential for all individuals to recover from psychosis, to some extent. Experiencing psychosis may feel like a nightmare, but being told your life is over after having your first episode is just as scary.
“Adults with schizophrenia are about 10 times more likely to die of COPD and 7 times more likely to die of diabetes,” says a co-author of the study, Mark Olfson, MD, a psychiatrist at Columbia University Irving Medical Center in New York City.
Previous studies have found that patients with full-blown schizophrenia lack self-awareness of illness (4, 10). About 46% of FEP patients showed poor insight (11) and insight impairment is associated with multiple cognitive deficits (12).
Schizophrenia usually involves delusions (false beliefs), hallucinations (seeing or hearing things that don't exist), unusual physical behavior, and disorganized thinking and speech. It is common for people with schizophrenia to have paranoid thoughts or hear voices.
Haloperidol, fluphenazine, and chlorpromazine are known as conventional, or typical, antipsychotics and have been used to treat schizophrenia for years.
Many people with schizophrenia are able to live independently. However, this is not the case for all people with schizophrenia. There are several things that people with schizophrenia should know to overcome the difficulties of their illness and live on their own: Early diagnosis and treatment leads to better outcomes.
Connecting face-to-face with others is the most effective way to calm your nervous system and relieve stress. Since stress can trigger psychosis and make the symptoms of schizophrenia worse, keeping it under control is extremely important.
Schizophrenia Recovery
Some people do recover “fully” from schizophrenia. Ten years after diagnosis: 50% of people with schizophrenia recover or improve to the point they can work and live on their own. 25% are better but need help from a strong support network to get by.
Does Schizophrenia Get Worse if Untreated? If left untreated, schizophrenia rarely gets better on its own. Symptoms of schizophrenia more frequently increase in intensity without treatment and may even lead to the onset of additional mental issues, including: Depression.
The exact causes of schizophrenia are unknown. Research suggests a combination of physical, genetic, psychological and environmental factors can make a person more likely to develop the condition. Some people may be prone to schizophrenia, and a stressful or emotional life event might trigger a psychotic episode.
Compared to controls, patients with schizophrenia had significantly smaller gray matter intracranium and total brain volumes, increased 4th ventricle volumes, and greater temporal and occipital ADCs.
The Brain In Schizophrenia
The fluid-filled spaces (the ventricles) in the interior of the temporal lobes are often enlarged and the temporal lobe tissue diminished. The greater the observed changes the greater the severity of the person's thought disorder and his or her auditory hallucinations.
Schizophrenia is a chronic progressive disorder that has at its origin structural brain changes in both white and gray matter. It is likely that these changes begin prior to the onset of clinical symptoms in cortical regions, particularly those concerned with language processing.