The majority of individuals with RSS are of normal intelligence, but motor and/or speech delay is common. RSS is genetically heterogeneous, meaning that different genetic abnormalities are known to cause the disorder.
There is a wide degree of variability in cognitive and adaptive function in individuals with RSS. Learning disabilities and attention deficit disorders (ADD) appear to be increased in individuals with RSS.
Russell-Silver syndrome is also associated with an increased risk of delayed development, speech and language problems, and learning disabilities.
An adult female with typical features of Silver-Russell dwarfism gave birth to a viable infant. Despite the abnormalities in sexual development that may be associated with the Silver-Russell syndrome, fertility is not necessarily impaired, at least in females.
LP's history and test findings yielded a profile consistent with a nonverbal learning disability, with significantly higher verbal compared to nonverbal intelligence, deficient visual-spatial memory, fine motor coordination and motor planning problems, relatively greater difficulty in math compared to other achievement ...
Abnormalities involving genes on chromosome 7 can also cause Russell-Silver syndrome. In 7 percent to 10 percent of cases, people inherit both copies of chromosome 7 from their mother instead of one copy from each parent.
With early intervention and treatment, Russell-Silver syndrome isn't a life-threatening condition. A team of specialists will work with you and your child so they can go on to lead a normal, healthy life.
Russell-Silver syndrome (RSS) is a rare disorder characterized by intrauterine growth restriction (IUGR), poor growth after birth, a relatively large head size, a triangular facial appearance, a prominent forehead (looking from the side of the face), body asymmetry and significant feeding difficulties.
Silver-Russell syndrome is characterized by intrauterine and postnatal growth retardation leading to a small-for-gestational-age (SGA) infant at birth, feeding difficulties during infancy, short stature, body asymmetry, characteristic triangular facies with prominent forehead, and several other anomalies.
Silver-Russell syndrome (SRS; OMIM 180860) and Beckwith-Wiedemann syndrome (BWS; OMIM 130650) are 2 clinically opposite growth-affecting congenital imprinting disorders.
Silver–Russell syndrome (SRS), also called Silver–Russell dwarfism, is a rare congenital growth disorder. In the United States it is usually referred to as Russell–Silver syndrome (RSS), and Silver–Russell syndrome elsewhere. It is one of 200 types of dwarfism and one of five types of primordial dwarfism.
Silver-Russell syndrome-5 (SRS5) is characterized by intrauterine growth retardation, with feeding difficulties in early childhood and postnatal growth failure. Relative macrocephaly may be present at birth. Other dysmorphic features include triangular face with prominent forehead (De Crescenzo et al., 2015).
Silver–Russell syndrome (SRS)
A distinct syndromic growth disorder in which prenatal and postnatal growth failure are associated with other characteristic features, including relative macrocephaly at birth, protruding forehead in early life, body asymmetry and substantial feeding difficulties.
Learning disabilities affect how a person learns to read, write, speak, and do math. They are caused by differences in the brain, most often in how it functions but also sometimes in its structure. These differences affect the way the brain processes information.
Often, learning problems can run in families (genetic), but environmental factors can play a role too. Mostly, learning disabilities occur because there is an enormous range of variation that occurs normally in people's cognitive strengths and weaknesses.
Babies with this condition typically have difficulty feeding and growing. Although adolescents and adults with Russell-Silver syndrome will be shorter than average, most people with RSS will live full, productive lives.
SRS may also occur as the result of a genetic alteration associated with up to a 50% recurrence risk (e.g., a copy number variant on chromosome 7 or 11 or an intragenic pathogenic variant in CDKN1C, IGF2, PLAG2, or HMGA2) depending on the nature of the genetic alteration and the sex of the transmitting parent.
Silver-Russell syndrome due to maternal uniparental disomy of chromosome 7 is a genetic malformation syndrome with short stature characterized by severe prenatal and postnatal growth retardation, feeding difficulties, body asymmetry, dysmorphic craniofacial features (triangular-shaped face, relative macrocephaly, ...
Hunter-Russell syndrome (uncountable) A condition caused by methylmercury poisoning, characterised by paresthesia, ataxia, and impaired speech and vision.
People with Marfan syndrome are often tall and thin, with very long arms, legs, fingers, and toes. People who might have Marfan syndrome should be evaluated to help reduce the risk of potential heart problems.
Overview. Turner syndrome, a condition that affects only females, results when one of the X chromosomes (sex chromosomes) is missing or partially missing. Turner syndrome can cause a variety of medical and developmental problems, including short height, failure of the ovaries to develop and heart defects.
Wolff-Parkinson-White syndrome is a rare condition and diagnosis might be missed. Identification of this disease is important to prevent further arrhythmias and sudden cardiac death. Arrhythmias can be life-threatening to both the fetus and the mother, so close monitoring should be done.
Edwards syndrome is a genetic condition in babies that causes severe disability. It is caused by an extra copy of chromosome 18 and babies born with the condition usually do not survive for much longer than a week.