Yes, Pfizer developed and has offered Omicron-targeting boosters, including a bivalent Original/Omicron BA.4-5 vaccine and later a monovalent Omicron XBB.1.5 vaccine, approved for booster shots in various age groups to target evolving variants. These updated vaccines provide broader protection against Omicron sublineages.
Pfizer COVID-19 bivalent (COMIRNATY Original/Omicron BA.4-5 COVID-19 vaccine) booster dose vaccine.
Pfizer Inc. and BioNTech SE today announced that the U.S. Food and Drug Administration (FDA) has expanded the emergency use authorization (EUA) of a booster dose of the Pfizer-BioNTech COVID-19 Vaccine to include individuals 18 years of age and older.
(NYSE: PFE, “Pfizer”) and BioNTech SE (Nasdaq: BNTX, “BioNTech”) today announced the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application (sBLA) for the companies' LP. 8.1-adapted monovalent COVID-19 vaccine (COMIRNATY® LP.
The new booster is a bivalent vaccine, which means it contains two messenger RNA (mRNA) components of the coronavirus. Half of the vaccine targets the original strain, and the other half targets the BA. 4 and BA. 5 Omicron subvariant lineages, which are predicted to continue circulating this fall and winter.
Currently, the dominant variant nationwide is XFG, with 61% of cases, followed by XFG.14.1, with 15% of cases, and XFG.1, with 5% of cases. "The original omicron variant is gone now," says Dr. Rupp. "Currently subvariants of omicron are circulating, including XFV, NW.1 and XFZ."
A booster shot with the Moderna vaccine offered older people better protection against COVID-19 if they had previously taken Pfizer jabs, researchers at the National Centre for Infectious Diseases (NCID) have found.
This study concluded that the most frequent adverse effects of the Pfizer vaccine were burning at the injection site, fever, pain at the injection site, muscle pain, swelling at the injection site, and joint pain. Moreover, the first dose was associated with more side effects than the second dose.
Spikevax (COVID-19 Vaccine, mRNA) 2025-2026 Formula is an updated vaccine indicated for active immunization to prevent COVID-19 caused by SARS-CoV-2 in individuals 65 years of age and older, or 6 months through 64 years at high risk for severe COVID-19.
How long do spike proteins last in the body? The Infectious Disease Society of America (IDSA) estimates that the spike proteins that were generated by COVID-19 vaccines last up to a few weeks, like other proteins made by the body.
That means if your first two doses were with the Pfizer vaccine, you can receive a booster dose with the Moderna vaccine.
Moderna uses the same mRNA technology as Pfizer-BioNTech and had a similarly high efficacy at preventing symptomatic disease when the companies applied for authorization.
Get the facts on COVID-19
While there is no preference for any approved COVID-19 vaccine, at your local Walgreens retail pharmacy you can select Pfizer or Moderna when scheduling an appointment. Vaccine availability varies by Walgreens locations and not all may be available in all areas.
Key points for 2025
The current COVID-19 vaccines available for use are Comirnaty JN. 1 and Omicron XBB. 1.5-containing vaccines. COVID-19 vaccines can be co-administered with any other vaccine for people aged ≥5 years.
The 2025-2026 COVID-19 vaccines available in the United States include Moderna, Pfizer-BioNTech and Novavax. The vaccines are all approved for people age 65 and older. Each vaccine is also approved for younger people with a health condition that raises the risk of serious COVID-19 illness.
COMIRNATY Original/Omicron BA. 4-5 15/15 micrograms per dose Dispersion for Injection, COVID-19 mRNA Vaccine (nucleoside modified) is called COMIRNATY (Bivalent) (For 12 Years of Age and Older) (Vials with Grey Cap). COMIRNATY (Bivalent) is a vaccine used for preventing COVID-19 caused by SARS-CoV-2 virus.
On August 27, 2025, the Food and Drug Administration revoked the emergency use authorization (EUA) of Pfizer-BioNTech COVID-19 Vaccine. Comirnaty (COVID-19 Vaccine, mRNA), manufactured by Pfizer Inc., is approved for use by FDA.
Moderna (mNexspike), Moderna (Spikevax), Novavax, and Pfizer-BioNTech COVID-19 vaccines are approved for this age group. Novavax is administered as a single dose for initial vaccination. Unvaccinated: Administer 1 dose of 2025–2026 vaccine.
The COVID-19 vaccines given in the UK are made by Pfizer. You can check the ingredients in the patient leaflets: Pfizer/BioNTech (Comirnaty) COVID-19 vaccine for people aged 12 and over (Electronic Medicines Compendium website; PDF only, 207KB)
(NYSE: PFE) today reaffirmed the safety and efficacy of the COVID-19 vaccine and posted resources supporting its impact on global health. These sources reflect the company's commitment to transparency and ensure the accessibility of the data.
Nearly four years after Covid's emergence, plenty of people have tested positive at least twice. But an unlucky group has been hit with reinfection after reinfection. “I've seen a few patients with five infections,” said Dr. Grace McComsey, vice dean for clinical and translational research at Case Western University.
Public health has also made it clear that it is safe to mix and match Pfizer and Moderna COVID vaccines for booster shots.
The RSV vaccine helps protect against infection with RSV, a common virus that can make babies and older adults seriously ill. It's offered on the NHS if you're pregnant, aged 75 to 79, or turned 80 after 1 September 2024.
It is especially important to get your 2025–2026 COVID-19 vaccine if you are ages 65 and older, are at high risk for severe COVID-19, or have never received a COVID-19 vaccine. Parents of children ages 6 months to 17 years should discuss the benefits of vaccination with a healthcare provider.