Magnesium has an important role when it comes to mast cells and histamine. It helps support DAO levels by reducing the amount of histidine (an amino acid) that gets converted to histamine. In an animal study, researchers found 4 days of low magnesium intake caused histamine to rise quickly. and it kept getting worse.
Diamine oxidase (DAO) supplements are over-the-counter products that restore the diamine oxidase enzyme in your body. They help break down histamine-rich foods and may reduce symptoms of histamine intolerance. Research shows that these supplements might offer relief from headaches, digestive issues, and skin reactions.
Magnesium[edit | edit source]
Like Vitamin C, magnesium is a co-factor in the production of diamine oxidase. Magnesium deficiency has been seen to increase mast cell production in some cases; therefore magnesium supplementation may be helpful in controlling mast cell division.
Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.
Vitamin C is a natural antihistamine, which means it can lower histamine levels and mitigate allergic reactions and symptoms. Consume plenty of Vitamin C rich foods, like tropical fruits, citrus fruits, broccoli and cauliflower, and berries.
The best way to clear histamine from the body is to start an elimination diet that involves only eating and drinking substances that contain low amounts of histamine.
Seasonal allergies are often the cause of histamine production in the body, but foods can also contain this chemical.
Summary. Natural antihistamines may help you control your seasonal allergies. Common ones are stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics. Some alternative practices—such as acupuncture, nasal irrigation, and exercise—may also help you manage symptoms.
Nettles. Nettle leaf is a natural antihistamine that naturally blocks histamine production. It can be made in to a tincture or tea, but for allergy relief, capsules made from dried nettle leaves are the most effective option.
“Antihistamines” control allergy symptoms by blocking histamine activity. But our body can also produce enzymes such as histamine-N-methyltransferase and diamine oxidase (DAO) capable of inactivating histamine.
“Magnesium-rich foods, such as almonds, cashews, wheat bran, and kelp, are excellent foods for allergy relief, because magnesium is a bronchodilator and an antihistamine,” Dr. Dean says.
The zinc chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) inhibits the release of histamine, the production of cytokines, and the secretion of lipid mediators in mast cells, and zinc supplementation rescues these inhibitory effects.
A single application of vitamin D3 to the skin decreased the immediate skin response to an IgE allergen. It decreased production of leukotrienes and histamine.
Medications, such as certain painkillers (ibuprofen and morphine, among others), antibiotics and drugs for high blood pressure, can also release histamine. A vitamin B12 injection also releases (a lot of) histamine from the mast cells.
Block and reduce nighttime histamine release
You can block nighttime histamine release and get a better night's sleep by taking 0.25 -1 mg of ketotifen or zaditen at night.
Antihistamines are the first line of treatment in MCAD. Non-sedating H1 antihistamines, eg cetirizine, loratadine, fexofenadine, are often preferred.
Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract.
Vitamin C and E are necessary in allergic disease treatment where mast cells are involved. In addition, ascorbic acid and pyridoxine are useful compounds for the treatment of inflammatory disorder of the respiratory airways.
5. Turmeric is a spice that can prevent the release of histamine from mast cells and can even inhibit anaphylactic reactions. It can be used in cooking or can be made into a tea.
The symptoms of histamine intolerance vary widely.
These include: Flushing, difficulty regulating body temperature, sudden excessive sweating. Hives, rashes, swelling, itchy skin, eczema. Racing heart, palpitations, arrhythmia.
Their effects may not be seen until 2 to 5 days after initiation of therapy, while their maximum benefit is achieved 15 days after initiating therapy.